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Up-regulated biglycan expression correlates with the malignancy in human colorectal cancers

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Abstract

Biglycan, an extracellular matrix protein, has been implicated in the oncogenesis and cancer development in various types of human cancer. The clinical significance of biglycan in colorectal cancer, however, remains unclear. In the present study, biglycan mRNA expression was analyzed in 110 samples (primary colorectal tumor and matched adjacent normal tissue) derived from 55 patients with colorectal cancer using quantitative real-time RT-PCR. The correlations between biglycan up-regulation and the clinicopathological data were also evaluated. We found that the up-regulation of biglycan occurred in 61.8% (34/55) of colorectal cancer tissues, and biglycan expression in colorectal cancer tissues was markedly higher than that in corresponding normal tissues (P = 0.0264). Moreover, statistical analysis displayed a significant correlation in biglycan up-regulation with poor tumor differentiation (P = 0.009), lymph node metastasis (P = 0.041), and distant metastasis (P = 0.036). However, there was no significant correlation between biglycan up-regulation and other clinicopathological factors (all P > 0.05). In conclusion, biglycan may be a potential marker for the malignancy of colorectal cancer.

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Authors and Affiliations

  1. Department of Surgical Oncology, Liaoning Cancer Hospital and Institute, Shenyang, 110042, People’s Republic of China

    Xiaohu Gu, Yegang Ma & Chun Song

  2. Department of Digestive Diseases, Liaoning University of Traditional Chinese Medicine, Shenyang, 110032, People’s Republic of China

    Jingdong Xiao

  3. Department of Basic Chinese Medicine, Liaoning University of Traditional Chinese Medicine, Shenyang, 110032, People’s Republic of China

    Hongxin Zheng

  4. Department of Oncology, China Medical University, Shenyang, 110001, People’s Republic of China

    Yuehua Gong

  5. Department of Internal Oncology, Liaoning Cancer Hospital and Institute, 44 Xiaoheyan Road, Shenyang, 110042, People’s Republic of China

    Xiaojing Xing

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  1. Xiaohu Gu
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  2. Yegang Ma
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  3. Jingdong Xiao
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  4. Hongxin Zheng
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  5. Chun Song
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  6. Yuehua Gong
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  7. Xiaojing Xing
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Correspondence to Xiaojing Xing.

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Gu, X., Ma, Y., Xiao, J. et al. Up-regulated biglycan expression correlates with the malignancy in human colorectal cancers. Clin Exp Med 12, 195–199 (2012). https://doi.org/10.1007/s10238-011-0155-4

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  • DOI: https://doi.org/10.1007/s10238-011-0155-4

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