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Apolipoprotein A1 gene polymorphisms as risk factors for hypertension and obesity

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Abstract

Several polymorphisms in apolipoprotein A1 (APOA1) gene have been associated with metabolic diseases. Increased transcription efficiency was observed in −75A allele carriers compared to −75G allele homozygotes. +83C allele was associated with higher body mass index and waist-to-hip ratio in type II diabetes subjects. −75G/A and +83C/T polymorphisms were analyzed by RFLP-PCR in 334 individuals from a Brazilian elderly cohort. APOA1 polymorphisms were associated with age-related morbidities, as well as with triglycerides, total cholesterol, HDL, VLDL, LDL, creatinine, urea, albumin, glycated hemoglobin and fasting glucose serum levels. Allele frequencies were 0.102 and 0.21, respectively, for −75A and +83T. −75G allele showed significant association with hypertension (P = 0.001). An association between +83C allele and obesity was observed (P = 0.040) and this allele also showed an association with hypertension in the presence of cardiovascular disease (P = 0.047). Moreover, +83T allele was associated with lower glycated hemoglobin values (P = 0.026). To our knowledge, there is no data associating this polymorphism with glycated hemoglobin. Furthermore, individuals carrying AT haplotype have lower risk for developing hypertension (P = 0.0002), while GT haplotype carriers present decreased risk to develop obesity comparing to GC haplotype (P = 0.025). APOA1 polymorphisms analysis may be a useful tool to identify risk factors for subjects and families and clarify the physiopathological role of these polymorphisms in age-related diseases, such as hypertension and obesity.

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Acknowledgments

This research was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Brazil), Coordenadoria de Aperfeiçoamento de Pessoal de Ensino Superior (CAPES, Brazil) and Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, Brazil).

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The authors declare that they have no conflict of interest related to the publication of this manuscript.

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Authors and Affiliations

  1. Disciplina de Genética, Departamento de Morfologia e Genética, Escola Paulista de Medicina/Universidade Federal de São Paulo, Rua Botucatu, 740, Edifício Leitão da Cunha–1 andar, São Paulo, SP, CEP 04023-900, Brazil

    Elizabeth Suchi Chen, Diego Robles Mazzotti, Tatiane Katsue Furuya, Rommel Rodriguez Burbano & Marília de Arruda Cardoso Smith

  2. Geriatrics Division, Department of Medicine, UNIFESP, São Paulo, Brazil

    Maysa Seabra Cendoroglo, Luiz Roberto Ramos & Lara Quirino Araujo

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  1. Elizabeth Suchi Chen
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Correspondence to Marília de Arruda Cardoso Smith.

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Chen, E.S., Mazzotti, D.R., Furuya, T.K. et al. Apolipoprotein A1 gene polymorphisms as risk factors for hypertension and obesity. Clin Exp Med 9, 319–325 (2009). https://doi.org/10.1007/s10238-009-0051-3

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