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Significance of survivin, caspase-3, and VEGF expression in thyroid carcinoma

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Abstract

To investigate the clinical significance of survivin, caspase-3, and vascular endothelial growth factor expression in a subset of thyroid carcinoma and their correlation with prognosis. Sixty-eight cases of thyroid carcinoma (TC), 12 cases of thyroid adenoma (TA) and 10 cases of normal thyroid tissue (NT) were involved in immunohistochemical and real-time RT-PCR analyses for survivin, caspase-3, and VEGF expression. Statistical analyses were performed for differential expression among NT, TA and TC, correlations of their expression with the clinicopathological parameters of TC including histological typing, clinical staging and lymphnode metastasis, and relationship of survivin with caspase-3 or VEGF in TC. We observed higher mRNA expression and positive immunostaining for survivin and VEGF in TC compared with TA and NT, with a significant positive correlation among them and significant correlations with histological typing, clinical staging and lymphnode metastasis in TC, but we could not find any significance of caspase-3 in TC and its significant relationship with survivin expression. Our results indicate that survivin and VEGF are unfavorable molecules for TC evolution and prognosis, and possess positive correlation in TC.

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Acknowledgments

This work was partially supported by Foundation from Shenyang Science and Technology Bureau to Wei-Wei Deng (No. 1063316-1-00).

Conflict of interest statement

We have no conflict of interest related to the publication of this manuscript.

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Authors and Affiliations

  1. Department of Geriatrics, The First Affiliated Hospital, China Medical University, No. 155, Nanjingbei Street, Heping District, 110001, Shenyang, Liaoning Province, People’s Republic of China

    Hai-Yan Zhang & Wei-Wei Deng

  2. Division of Molecular and Clinical Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812-8582, Japan

    Xin Meng

  3. Department of Endocrinology and Metabolism, The First Affiliated Hospital, China Medical University, 110001, Shenyang, People’s Republic of China

    Zhen-Xian Du & Guo-Liang Liu

  4. Department of Pathology, Basic Medical College, The First Affiliated Hospital, China Medical University, 110001, Shenyang, People’s Republic of China

    Chang-Qing Fang

  5. Department of Biochemistry and Molecular Biology, Basic Medical College, China Medical University, 110001, Shenyang, People’s Republic of China

    Xin Meng & Hua-Qin Wang

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  1. Hai-Yan Zhang
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  2. Xin Meng
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  3. Zhen-Xian Du
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  4. Chang-Qing Fang
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  5. Guo-Liang Liu
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  6. Hua-Qin Wang
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  7. Wei-Wei Deng
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Correspondence to Hai-Yan Zhang.

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Zhang, HY., Meng, X., Du, ZX. et al. Significance of survivin, caspase-3, and VEGF expression in thyroid carcinoma. Clin Exp Med 9, 207–213 (2009). https://doi.org/10.1007/s10238-009-0031-7

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  • DOI: https://doi.org/10.1007/s10238-009-0031-7

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