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Altered mechano-chemical environment in hip articular cartilage: effect of obesity

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Abstract

The production of extracellular matrix (ECM) components of articular cartilage is regulated, among other factors, by an intercellular signaling mechanism mediated by the interaction of cell surface receptors (CSR) with insulin-like growth factor-1 (IGF-1). In ECM, the presence of binding proteins (IGFBP) hinders IGF-1 delivery to CSR. It has been reported that levels of IGF-1 and IGFBP in obese population are, respectively, lower and higher than those found in normal population. In this study, an experimental–numerical approach was adopted to quantify the effect of this metabolic alteration found in obese population on the homeostasis of femoral hip cartilage. A new computational model, based on the mechano-electrochemical mixture theory, was developed to describe competitive binding kinetics of IGF-1 with IGFBP and CSR, and associated glycosaminoglycan (GAG) biosynthesis. Moreover, a gait analysis was carried out on obese and normal subjects to experimentally characterize mechanical loads on hip cartilage during walking. This information was deployed into the model to account for effects of physiologically relevant tissue deformation on GAG production in ECM. Numerical simulations were performed to compare GAG biosynthesis in femoral hip cartilage of normal and obese subjects. Results indicated that the lower ratio of IGF-1 to IGFBP found in obese population reduces cartilage GAG concentration up to 18 % when compared to normal population. Moreover, moderate physical activity, such as walking, has a modest beneficial effect on GAG production. The findings of this study suggest that IGF-1/IGFBP metabolic unbalance should be accounted for when considering the association of obesity with hip osteoarthritis.

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Acknowledgments

This study was supported by funds donated to the Biomechanics Research Group of the University of Miami. The authors wish to thank Dr. Roberto Serpieri for his insightful comments on the formulation of the numerical model.

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Authors and Affiliations

  1. Biomechanics Research Laboratory, Department of Industrial Engineering, College of Engineering, University of Miami, 1251 Memorial Drive, MEB 268, Coral Gables, FL, 33124-0621, USA

    Francesco Travascio, Moataz Eltoukhy, Sonila Cami & Shihab Asfour

  2. Sports Medicine and Motion Analysis Laboratory, Department of Kinesiology and Sport Science, University of Miami, Coral Gables, FL, USA

    Moataz Eltoukhy

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  1. Francesco Travascio
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Correspondence to Shihab Asfour.

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Travascio, F., Eltoukhy, M., Cami, S. et al. Altered mechano-chemical environment in hip articular cartilage: effect of obesity. Biomech Model Mechanobiol 13, 945–959 (2014). https://doi.org/10.1007/s10237-013-0545-5

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