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Simulation of bone tissue formation within a porous scaffold under dynamic compression

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Abstract

A computational model of mechanoregulation is proposed to predict bone tissue formation stimulated mechanically by overall dynamical compression within a porous polymeric scaffold rendered by micro-CT. Dynamic compressions of 0.5–5% at 0.0025–0.025 s−1 were simulated. A force-controlled dynamic compression was also performed by imposing a ramp of force from 1 to 70 N. The model predicts homogeneous mature bone tissue formation under strain levels of 0.5–1% at strain rates of 0.0025–0.005 s−1. Under higher levels of strain and strain rates, the scaffold shows heterogeneous mechanical behaviour which leads to the formation of a heterogeneous tissue with a mixture of mature bone and fibrous tissue. A fibrous tissue layer was also predicted under the force-controlled dynamic compression, although the same force magnitude was found promoting only mature bone during a strain-controlled compression. The model shows that the mechanical stimulation of bone tissue formation within a porous scaffold closely depends on the loading history and on the mechanical behaviour of the scaffold at local and global scales.

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Authors and Affiliations

  1. Institute for Bioengineering of Catalonia (IBEC), Technical University of Catalonia, Barcelona, Spain

    Jean-Louis Milan, Josep A. Planell & Damien Lacroix

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  1. Jean-Louis Milan
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  2. Josep A. Planell
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  3. Damien Lacroix
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Correspondence to Jean-Louis Milan.

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Milan, JL., Planell, J.A. & Lacroix, D. Simulation of bone tissue formation within a porous scaffold under dynamic compression. Biomech Model Mechanobiol 9, 583–596 (2010). https://doi.org/10.1007/s10237-010-0199-5

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  • DOI: https://doi.org/10.1007/s10237-010-0199-5

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