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Modeling distraction osteogenesis: analysis of the distraction rate

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Abstract

Distraction osteogenesis is a useful technique aimed at inducing bone formation in widespread clinical applications. One of the most important factors that conditions the success of bone regeneration is the distraction rate. Since the mechanical environment around the osteotomy site is one of the main factors that affects both quantity and quality of the regenerated bone, we have focused on analyzing how the distraction rate influences on the mechanical conditions and tissue regeneration. Therefore, the aim of the present work is to explore the potential of a mathematical algorithm to simulate clinically observed distraction rate related phenomena that occur during distraction osteogenesis. Improvements have been performed on a previous model (Gómez-Benito et al. in J Theor Biol 235:105–119, 2005) in order to take into account the load history. The results obtained concur with experimental findings: a slow distraction rate results in premature bony union, whereas a fast rate results in a fibrous union. Tension forces in the interfragmentary gap tissue have also been estimated and successfully compared with experimental measurements.

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Authors and Affiliations

  1. Department of Mechanical Engineering, University of Seville, 41092, Seville, Spain

    E. Reina-Romo & J. Domínguez

  2. Group of Structural Mechanics and Materials Modelling, Aragón Institute of Engineering Research (I3A), University of Zaragoza, C/María de Luna 5, “Agustín de Betancourt” Building, 50018, Zaragoza, Spain

    M. J. Gómez-Benito, J. M. García-Aznar & M. Doblaré

  3. Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Zaragoza, Spain

    M. J. Gómez-Benito, J. M. García-Aznar & M. Doblaré

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  1. E. Reina-Romo
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  2. M. J. Gómez-Benito
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  3. J. M. García-Aznar
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  4. J. Domínguez
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  5. M. Doblaré
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Correspondence to E. Reina-Romo.

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Reina-Romo, E., Gómez-Benito, M.J., García-Aznar, J.M. et al. Modeling distraction osteogenesis: analysis of the distraction rate. Biomech Model Mechanobiol 8, 323–335 (2009). https://doi.org/10.1007/s10237-008-0138-x

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  • DOI: https://doi.org/10.1007/s10237-008-0138-x

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