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Multiple Keratoacanthomas Arising Post-UVB Therapy

  • Case Report
  • Published:
Journal of Cutaneous Medicine and Surgery

Abstract

Background

Ultraviolet (UV) radiation is known to be an important etiologic agent in the development of skin cancer. Keratoacanthoma is an unusual, well-described cutaneous neoplasm that resembes squamous cell carcinoma but spontaneously resolves. Rarely, multiple keratoacanthomas may develop.

Objective

We present a case of multiple keratoacanthomas in a patient with psoriasis who had received UVB phototherapy. These lesions were hyperkeratotic papules, many of which spontaneously resolved and demonstrated the histologic characteristics of keratoacanthoma.

Conclusion

We believe that UV radiation is the most likely etiologic factor in this patient’s development of multiple keratoacanthomas. We wish to bring to the attention of clinicians this unusual adverse effect of UV treatment.

Sommaire

Antécédents

On sait que les rayons UV sont un agent étiologique important dans le développement du cancer de la peau. Le kératoacanthome est un néoplasme inusuel, bien décrit, ressemblant aux carcinomes squameux mais autorésolutif. II est rare qu’un kératoacanthome multiple se développe.

Objectif

Nous présentons le cas de kératoacanthomes multiples chez un patient souffrant de psoriasis qui a reçu une photothérapie UVB. Ses lésions étaient à I’origine des papules hyperkératosiques, dont un grand nombre a guéri spontanément et a présenté les caractéristiques histologiques d’un kératoacanthome.

Conclusion

Nous pensons que les rayons UV sont probablement le facteur étiologique à I’origine du développement de kératoacanthomes multiples chez ce patient. Nous désirons attirer I’attention des cliniciens sur cet effet défavorable du traitement UV.

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Acknowledgments

Thanks to Tom Turner for help in obtaining photomicrographs and clinical photographs.

Author information

Authors and Affiliations

  1. Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada

    Kenneth J. Craddock & Victor A. Tron

  2. Division of Dermatology and Cutaneous Sciences, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada

    Jaggi Rao & Gilles J. Lauzon

Authors
  1. Kenneth J. Craddock
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  2. Jaggi Rao
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  3. Gilles J. Lauzon
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  4. Victor A. Tron
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Corresponding author

Correspondence to Victor A. Tron.

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Craddock, K.J., Rao, J., Lauzon, G.J. et al. Multiple Keratoacanthomas Arising Post-UVB Therapy. J Cutan Med Surg 8, 239–243 (2004). https://doi.org/10.1007/s10227-004-0122-8

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  • DOI: https://doi.org/10.1007/s10227-004-0122-8

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