Abstract
Objectives
This study aimed to evaluate fatigue in Turkish patients with ankylosing spondylitis (AS) and its relationship with disease-specific variables, spinal mobility measures, and health-related quality of life (HR-QoL).
Methods
One hundred and ten patients diagnosed as AS according to the Modified New York Criteria and 40 healthy individuals were included in this study. The Multidimensional Assessment of Fatigue (MAF) was used in patient and control groups to assess fatigue. The first item of Bath AS Disease Activity Index (BASDAI) was also used to assess fatigue in the patient group. Evaluation included BASDAI, functional status [BAS Functional Index (BASFI)], and visual analog scale (VAS) of axial and joint pain. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were also measured. The generic instrument Short Form 36 (SF 36) was used to assess HR-QoL in the patient group.
Results
Patients with AS had higher total MAF scores and in all MAF subgroup scales than controls. All patient MAF scores were significantly correlated with morning stiffness, number of swollen joints, history of peripheral arthritis, BASDAI, BASFI, BASDAI-fatigue, VAS axial, VAS peripheral, and SF 36 subgroups (p < 0.05). No correlation was observed between all MAF scores and age, body mass index (BMI), disease duration, meteorological measures, and medications in patients.
Conclusions
Patients with AS defined significantly more fatigue when compared with healthy persons. MAF was related to clinical and functional status and HR-QoL of patients with AS. We assume that MAF can be used as a sensitive fatigue measure in patients with AS.
Similar content being viewed by others
References
Gran JT, Skomsvoll JF. The outcome of ankylosing spondylitis; a study of 100 patients. Br J Rheumatol. 1997;36:766–71.
Ward MM. Health-related quality of life in ankylosing spondylitis: a survey of 175 patients. Arthritis Care Res. 1999;12:247–55.
Dagfinrud H, Vollestad NK, Loge JH, Kvien TK, Mengshoel AM. Fatigue in patients with ankylosing spondylitis: a comparison with the general population and associations with clinical and self-reported measures. Arthritis Rheum. 2005;53:5–11.
Missaoui B, Revel M. Review: fatigue in ankylosing spondylitis. Ann Readapt Med Phys. 2006;49:389–91.
Swain MG. Fatigue in chronic disease. Clin Sci. 2000;99:1–8.
Neuberger GB. Measures of fatigue. Arthritis Rheum. 2003;49:175–83.
Van der Linden S, Valkenburg HA, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis: a proposal for the modiffcation of the New York criteria. Arthritis Rheum. 1984;27:361–8.
Akkoc Y, Karatepe AG, Akar S, Kirazli Y, Akkoc N. A Turkish version of the bath ankylosing spondylitis disease activity index: reliability and validity. Rheumatol Int. 2005;25:280–4.
Garrett SL, Jenkinson TR, Kennedy LG, Whitelock HC, Gaisford P, Calin A. A new approach to defining disease status in ankylosing spondylitis: the bath ankylosing spondylitis disease activity index. J Rheumatol. 1994;21:2286–91.
Calin A, Garrett SL, Whitelock HC, Kennedy LG, O’Hea J, Mallorie P, et al. A new approach to defining functional ability in ankylosing spondylitis: the development of the bath ankylosing spondylitis functional index (BASFI). J Rheumatol. 1994;21:2281–5.
Yanik B, Gursel YK, Kutlay S, Ay S, Elhan AH. Adaptation of the bath ankylosing spondylitis functional index to the Turkish population, its reliability and validity: functional assessment in AS. Clin Rheumatol. 2005;24:41–7.
Ware JE Jr. SF-36 health survey update. Spine. 2000;25:3130–9.
Koçyiğit H, Aydemir Ö, Fişek G, Ölmez N, Memiş A. Kısa Form 36’nın Türkçe Versiyonunun Güvenilirliği ve Geçerliliği. İlaç ve Tedavi Dergisi. 1999;12:102–6.
Calin A, Edmunds L, Kennedy LG. Fatigue in ankylosing spondylitis: why is it ignored? J Rheumatol. 1993;20:991–5.
Jones SD, Koh WH, Steiner A, Garrett SL, Calin A. Fatigue in ankylosing spondylitis: its prevalence and relationship to disease activity, sleep, and other factors. J Rheumatol. 1996;23:487–90.
Aissaoui N, Rostom S, Hakkou J, Berrada Ghziouel K, Bahiri R, Abouqal R, et al. Fatigue in patients with ankylosing spondylitis: prevalence and relationships with disease-specific variables, psychological status, and sleep disturbance. Rheum Int. doi:10.1007/s00296-011-1928-5.
Van Tubergen A, Coenen J, Landewe R, Spoorenberg A, Chorus A, Boonen A, et al. Assessment of fatigue in patients with ankylosing spondylitis: a psychometric analysis. Arthritis Rheum. 2002;47:8–16.
Turan Y, Duruöz MT, Bal S, Guvenc A, Cerrahoglu L, Gurgan A. Assessment of fatigue in patients with ankylosing spondylitis. Rheumatol Int. 2007;27:847–52.
Riemsma RP, Rasker JJ, Taal E, Griep EN, Wouters JM, Wiegman O. Fatigue in rheumatoid arthritis: the role of self-eficacy and problematic social support. Br J Rheumatol. 1998; 371042–1046.
Russell AS. Ankylosing spondylitis, history. In: Klippel JH, Dieppe PA (eds) Rheumatology. Vol 1, 2nd edn. Mosby, London; 1998. pp 14.1–2.
Dernis-Labous E, Messow M, Dougados M. Assessment of fatigue in the management of patients with ankylosing spondylitis. Rheumatology. 2003;42:1523–8.
Yacoub Y, Amine B, Laatiris A, Abouqal R, Hajjaj-Hassouni N. Assessment of fatigue in Moroccan patients with ankylosing spondylitis. Clin Rheumatol. 2010;29:1295–9.
Conflict of interest
None.
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Alkan, B.M., Fidan, F., Erten, Ş. et al. Fatigue and correlation with disease-specific variables, spinal mobility measures, and health-related quality of life in ankylosing spondylitis. Mod Rheumatol 23, 1101–1107 (2013). https://doi.org/10.1007/s10165-012-0800-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10165-012-0800-0