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The development of Th1-mediated sarcoidosis improves the clinical course of Th2-mediated atopic dermatitis

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Modern Rheumatology

Abstract

Sarcoidosis is a chronic multisystem disease of unknown origin, which is characterized by T-helper-1 (Th1)-mediated immune responses. On the other hand, atopic dermatitis (AD) is characterized by Th2-mediated immune responses. We recently experienced an interesting case of AD in which the patient experienced a significant resolution of AD after the onset of sarcoidosis. We herein describe the details of his clinical course and discuss the impact of negative cross-regulation between Th1 and Th2 immune responses.

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Authors and Affiliations

  1. Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Tomomitsu Miyagaki, Yoshihide Asano, Sayaka Shibata, Yuki Ohno, Yuichiro Tsunemi, Hidehisa Saeki, Kunihiko Tamaki & Shinichi Sato

Authors
  1. Tomomitsu Miyagaki
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  2. Yoshihide Asano
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  3. Sayaka Shibata
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  4. Yuki Ohno
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  5. Yuichiro Tsunemi
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  6. Hidehisa Saeki
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  7. Kunihiko Tamaki
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  8. Shinichi Sato
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Corresponding author

Correspondence to Yoshihide Asano.

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Miyagaki, T., Asano, Y., Shibata, S. et al. The development of Th1-mediated sarcoidosis improves the clinical course of Th2-mediated atopic dermatitis. Mod Rheumatol 21, 406–409 (2011). https://doi.org/10.1007/s10165-010-0404-5

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  • DOI: https://doi.org/10.1007/s10165-010-0404-5

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