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Two cases of late-onset drug-induced lupus erythematosus caused by ticlopidine in elderly men

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Modern Rheumatology

Abstract

We have experienced two cases of drug-induced lupus erythematosus caused by ticlopidine in the last three years. Both were late-onset cases (1 and 4 years) that occurred in elderly men (76 and 81 years old). The common features were fever, arthralgia, myalgia, serositis, and the presence of anti-histone autoantibodies. Because ticlopidine is widely used in elderly people with ischemic vascular disease, ticlopidine-induced lupus should be considered when patients taking ticlopidine present lupus-like symptoms.

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Abbreviations

DILE:

Drug-induced lupus erythematosus

SLE:

Systemic lupus erythematosus

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Acknowledgments

This work was supported by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science, and a grant for Intractable Diseases from the Ministry of Health, Labor, and Welfare of Japan.

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Authors and Affiliations

  1. Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan

    Tomoko Yokoyama, Takashi Usui, Kazuhiro Kiyama, Ran Nakashima, Naoichiro Yukawa, Daisuke Kawabata, Takaki Nojima, Koichiro Ohmura, Takao Fujii & Tsuneyo Mimori

  2. Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Build. B, Konoe-cho, Yoshida, Sakyo-ku, Kyoto, 606-8501, Japan

    Takashi Usui

Authors
  1. Tomoko Yokoyama
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  2. Takashi Usui
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  3. Kazuhiro Kiyama
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  4. Ran Nakashima
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  5. Naoichiro Yukawa
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  6. Daisuke Kawabata
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  7. Takaki Nojima
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  8. Koichiro Ohmura
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  9. Takao Fujii
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  10. Tsuneyo Mimori
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Corresponding author

Correspondence to Takashi Usui.

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Yokoyama, T., Usui, T., Kiyama, K. et al. Two cases of late-onset drug-induced lupus erythematosus caused by ticlopidine in elderly men. Mod Rheumatol 20, 405–409 (2010). https://doi.org/10.1007/s10165-010-0289-3

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  • DOI: https://doi.org/10.1007/s10165-010-0289-3

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