Skip to main content

Advertisement

Log in

Use of etanercept in a patient with rheumatoid arthritis on hemodialysis

  • Case Report
  • Published:
Modern Rheumatology

Abstract

Disease-modifying anti-rheumatic drugs (DMARDs) are typically used for the therapy of rheumatoid arthritis (RA), but most have some nephrotoxicity. In several clinical studies, etanercept had fewer adverse effects on renal function than other DMARDs. We report the case of a 64-year-old woman with RA and renal insufficiency on hemodialysis treated using etanercept therapy. This case suggests that etanercept therapy might be effective in the short term for such patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  1. Stokes DG, Kremer JM. Potential of tumor necrosis factor neutralization strategies in rheumatologic disorders other than rheumatoid arthritis. Semin Arthritis Rheum. 2003;33:1–18.

    Article  PubMed  CAS  Google Scholar 

  2. Lee H, Kimko HC, Rogge M, Wang D, Nestorov I, Peck CC. Population pharmacokinetic and pharmacodynamic modeling of etanercept using logistic regression analysis. Clin Pharmacol Ther. 2003;73:348–65.

    Article  PubMed  CAS  Google Scholar 

  3. Don BR, Spin G, Nestorov I, Hutmacher M, Rose A, Kaysen GA. The pharmacokinetics of etanercept in patients with end-stage renal disease on haemodialysis. J Pharm Pharmacol. 2005;57:1407–13.

    Article  PubMed  CAS  Google Scholar 

  4. Nakamura M, Sakemi T, Nagasawa K. Severe pancytopenia caused by a single administration of low dose methotrexate in a patient undergoing hemodialysis. J Rheumatol. 1999;26:1424–5.

    PubMed  CAS  Google Scholar 

  5. Akiyama Y, Fujimaki T, Sakurai Y. Pharmacokinetics of salazosulfapyridine in a hemodialysis patient (in Japanese). Ryumachi. 2003;43:569–76.

    PubMed  Google Scholar 

  6. Hamada K. The safety of actarit (mover) in hemodialysis patients with rheumatoid arthritis (in Japanese). Prog Med. 1997;17:1652–7.

    Google Scholar 

  7. Kaizu K, Komine N, Uriu K, Ikeda M, Hashimoto O, Eto S. Bucillamine may be an effective anti-rheumatic drug in patients with end-stage renal disease—a case report (in Japanese). J Jpn Soc Dial Ther. 1994;27:1505–10.

    Google Scholar 

  8. Matthey F, Perrett D, Greenwood RN, Baker LRI. The use of d-penicillamine in patients with rheumatoid arthritis undergoing hemodialysis. Clin Nephrol. 1986;25:268–71.

    PubMed  CAS  Google Scholar 

  9. Saisho K, Kurosawa O, Fukanoki T, Hanafusa A, Tajima N. Long-term use of mizoribine in rheumatoid arthritis patients on hemodialysis. Mod Rheumatol. 2001;11:132–5.

    Article  CAS  Google Scholar 

  10. Beaman JM, Hackett LP, Luxton G, Illett KF. Effect of hemodialysis on leflunomide plasma concentrations. Ann Pharmacother. 2002;36:75–7.

    Article  PubMed  Google Scholar 

  11. Gruber SA, Hewitt JM, Sorenson AL. Pharmacokinetics of FK506 after intravenous and oral administration in patients awaiting renal transplantation. J Clin Pharmacol. 1994;34:859–64.

    PubMed  CAS  Google Scholar 

  12. Andoh TF, Burdmann EA, Lindsley J, Houghton DC, Bennett WM. Enhancement of FK506 nephrotoxicity by sodium depletion in an experimental rat model. Transplantation. 1994;57:483–9.

    Article  PubMed  CAS  Google Scholar 

  13. Singh R, Cuchacovich R, Huang W, Espinoza LR. Infliximab treatment in a patient with rheumatoid arthritis on hemodialysis. J Rheumatol. 2002;29:636–7.

    PubMed  Google Scholar 

  14. Hammoudeh M. Infliximab treatment in a patient with rheumatoid arthritis on haemodialysis. Rheumatology (Oxford). 2006;45:357–9.

    Article  CAS  Google Scholar 

Download references

Acknowledgments

The authors have no financial and personal relationship with the organization whose product or competing product plays a prominent role in this manuscript.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Tatsuya Koike.

About this article

Cite this article

Sugioka, Y., Inui, K. & Koike, T. Use of etanercept in a patient with rheumatoid arthritis on hemodialysis. Mod Rheumatol 18, 293–295 (2008). https://doi.org/10.1007/s10165-008-0041-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10165-008-0041-4

Keywords

Navigation