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Peripheral CD4+ T cells showing a Th2 phenotype in a patient with Mikulicz's disease associated with lymphadenopathy and pleural effusion

  • Case Report
  • Published:
Modern Rheumatology

Abstract

Mikulicz’s disease (MD) is a unique IgG4-related systemic disease indicated by enlargement of the lachrymal and salivary glands and which differs substantially from Sjögren’s syndrome. A male patient with pleural effusion, swelling of the submandibular glands, and swelling of the paraaortic, mediastinal, and pararenal lymph nodes was diagnosed with MD. Analysis of peripheral CD4+ T cells from the patient revealed deviation of the Th1/Th2 balance to Th2. Prednisolone therapy ameliorated the disease and corrected the Th1/Th2 imbalance.

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Acknowledgments

We are grateful to Dr. Hirotaka Higuchi and Dr. Katsuhiro Shimoda from Oita Tobu Hospital for introducing the patient to us and for providing detailed clinical information. There are no conflicts of interest associated with this article.

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Author notes

  1. Hitoshi Nakashima

    Present address: Division of Nephrology and Rheumatology, Department of Internal Medicine, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan

Authors and Affiliations

  1. Department of Medicine and Biosystemic Science, Graduate School of Medical Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Katsuhisa Miyake, Kumiko Aizawa, Shuji Nagano, Yasushi Inoue, Atsushi Sadanaga & Hitoshi Nakashima

  2. Department of Oral and Maxillofacial Surgery, Graduate School of Dental Science, Kyushu University, Fukuoka, Japan

    Masafumi Moriyama & Seiji Nakamura

Authors
  1. Katsuhisa Miyake
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  2. Masafumi Moriyama
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  3. Kumiko Aizawa
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  4. Shuji Nagano
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  5. Yasushi Inoue
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  6. Atsushi Sadanaga
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  7. Hitoshi Nakashima
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  8. Seiji Nakamura
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Corresponding author

Correspondence to Hitoshi Nakashima.

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Miyake, K., Moriyama, M., Aizawa, K. et al. Peripheral CD4+ T cells showing a Th2 phenotype in a patient with Mikulicz's disease associated with lymphadenopathy and pleural effusion. Mod Rheumatol 18, 86–90 (2008). https://doi.org/10.1007/s10165-007-0010-3

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  • DOI: https://doi.org/10.1007/s10165-007-0010-3

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