Skip to main content

Advertisement

SpringerLink
Log in

Efficacy profile of bucillamine in rheumatoid arthritis patients in a large observational cohort study, IORRA

  • ORIGINAL ARTICLE
  • Published:
Modern Rheumatology

Abstract

Bucillamine (Buc) is a disease-modifying antirheumatic drug (DMARD) developed in Japan, which has been used as one of the first-line DMARDs for the treatment of rheumatoid arthritis (RA) in Japan. However, direct comparison of this drug with standard DMARDs including sulfasalazine (SASP) and methotrexate (MTX) has been scarcely reported. We therefore tried to evaluate the clinical efficacy of Buc by analyzing the database from the long-term observational cohort study IORRA (previously known as J-ARAMIS). The cross-sectional analysis revealed that responses to Buc treatment were better in males, patients with shorter duration of illness, and those who were rheumatoid factor-negative. In the longitudinal analysis, although there was no marked difference among the baseline variables of patients with Buc, SASP, and MTX, the percentage of patients exhibiting moderate or good response to treatment, as rated using the European League Against Rheumatism improvement criteria, was higher in the Buc group (41.0%) than in the MTX (32.6%) and SASP groups (25.6%). These data support Buc as a candidate for being a first-line drug for the treatment of patients with RA.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. InstitutionalAuthorNameAmerican College of Rheumatology Subcommittee on Rheumatoid Arthritis Guidelines (2002) ArticleTitleGuidelines for the Management of Rheumatoid Arthritis. 2002 Update Arthritis Rheum 46 IssueID2 328–46 10.1002/art.10148 Occurrence Handle10.1002/art.10148

    Article  Google Scholar 

  2. A van der Heide JW Jacobs JW Bijlsma AH Heurkens C van Booma-Frankfort MJ vander Veen et al. (1996) ArticleTitleThe effectiveness of early treatment with “second-line” antirheumatic drugs. A randomized, controlled trial Ann Intern Med 124 IssueID8 699–707 Occurrence Handle1:CAS:528:DyaK28XislOisr8%3D Occurrence Handle8633829

    CAS  PubMed  Google Scholar 

  3. AA Stenger MA Van Leeuwen PM Houtman GA Bruyn F Speerstra BC Barendsen et al. (1998) ArticleTitleEarly effective suppression of inflammation in rheumatoid arthritis reduces radiographic progression Br J Rheumatol 37 IssueID11 1157–63 10.1093/rheumatology/37.11.1157 Occurrence Handle10.1093/rheumatology/37.11.1157 Occurrence Handle1:CAS:528:DyaK1MXkslGi Occurrence Handle9851262

    Article  CAS  PubMed  Google Scholar 

  4. C Abe (1985) ArticleTitleClinical evaluation of immunomodulators Int J Immunother 1 7–10

    Google Scholar 

  5. S Kashiwazaki Y Shiokawa (1987) ArticleTitleBucillamine: a new immunomodulator Int J Immunother 3 1–6

    Google Scholar 

  6. H Matsuno E Sugiyama A Muraguchi T Nezuka T Kubo K Matsuura et al. (1998) ArticleTitlePharmacological effects of SA96 (bucillamine) and its metabolites as immunomodulating drugs — the disulfide structure of SA-96 metabolites plays a critical role in the pharmacological action of the drug Int J Immunopharmacol 20 IssueID6 295–304 10.1016/S0192-0561(98)00012-5 Occurrence Handle10.1016/S0192-0561(98)00012-5 Occurrence Handle1:CAS:528:DyaK1cXlslGgtLY%3D Occurrence Handle9754677

    Article  CAS  PubMed  Google Scholar 

  7. S Hirohata PE Lipsky (1994) ArticleTitleComparative inhibitory effects of bucillamine and D-penicillamine on the function of human B cells and T cells Arthritis Rheum 37 IssueID6 942–50 Occurrence Handle10.1002/art.1780370625 Occurrence Handle1:CAS:528:DyaK2cXmt1Wgurg%3D Occurrence Handle8003068

    Article  CAS  PubMed  Google Scholar 

  8. S Hirohata PE Lipsky (1993) ArticleTitleRegulation of B cell function by bucillamine, a novel disease-modifying antirheumatic drug Clin Immunol Immunopathol 66 IssueID1 43–51 10.1006/clin.1993.1006 Occurrence Handle10.1006/clin.1993.1006 Occurrence Handle1:CAS:528:DyaK3sXptl2rtQ%3D%3D Occurrence Handle8440072

    Article  CAS  PubMed  Google Scholar 

  9. M Takai N Odani Y Tanimoto H Aono K Shimomura (2002) ArticleTitleThe effects of bucillamine and salazosulfapyridine on the joint destruction in rheumatoid arthritis Med Sci Dig 28 IssueID11 450–3

    Google Scholar 

  10. N Sekiguchi H Kameda K Amano T Takeuchi (2006) ArticleTitleEfficacy and safety of bucillamine, a D-penicillamine analogue, in patients with active rheumatoid arthritis Mod Rheumatol 16 IssueID2 85–91 10.1007/s10165-005-0466-y Occurrence Handle10.1007/s10165-005-0466-y Occurrence Handle1:CAS:528:DC%2BD28XjslKit70%3D Occurrence Handle16633927

    Article  CAS  PubMed  Google Scholar 

  11. M Nagashima G Shu K Yamamoto S Yamahatsu S Yoshino (2005) ArticleTitleThe ability of disease modifying antirheumatic drugs to induce and maintain improvement in patients with rheumatoid arthritis. Epidemiology of DMARDs treatment in Japan Clin Exp Rheumatol 23 IssueID1 27–35 Occurrence Handle1:STN:280:DC%2BD2M7lslWmtA%3D%3D Occurrence Handle15789884

    CAS  PubMed  Google Scholar 

  12. Y Matsuda G Singh H Yamanaka E Tanaka W Urano A Taniguchi et al. (2003) ArticleTitleValidation of a Japanese version of the Stanford Health Assessment Questionnaire in 3763 patients with rheumatoid arthritis Arthritis Rheum 49 IssueID6 784–8 10.1002/art.11465 Occurrence Handle10.1002/art.11465 Occurrence Handle14673964

    Article  PubMed  Google Scholar 

  13. H Yamanaka S Tohma (2006) ArticleTitlePotential impact of observational cohort studies in Japan on rheumatoid arthritis research and practice Mod Rheumatol 16 IssueID2 75–6 10.1007/s10165-006-0464-8 Occurrence Handle10.1007/s10165-006-0464-8 Occurrence Handle16633925

    Article  PubMed  Google Scholar 

  14. DE Furst (2004) ArticleTitleObservational cohort studies and well controlled clinical trials — we need them both! J Rheumatol 31 IssueID8 1476–7 Occurrence Handle15290723

    PubMed  Google Scholar 

  15. DMFM van der Heijde PLCM van Riel MA Leeuwen MA van't Hof MH van Rijswijk LBA van de Putte (1992) ArticleTitlePrognostic factors for radiographic damage and physical disability in early rheumatoid arthritis. A prospective follow-up study of 147 patients Br J Rheumatol 31 519–25 Occurrence Handle10.1093/rheumatology/31.8.519 Occurrence Handle1:STN:280:DyaK38zltlOltg%3D%3D Occurrence Handle1386548

    Article  CAS  PubMed  Google Scholar 

  16. Y Ichikawa T Saito H Yamanaka M Akizuki H Kondo S Kobayashi et al. (2005) ArticleTitleTherapeutic effects of the combination of methotrexate and bucillamine in early rheumatoid arthritis: a multicenter, double-blind, randomized controlled study Mod Rheumatol 15 323–8 10.1007/s10165-005-0420-z Occurrence Handle10.1007/s10165-005-0420-z Occurrence Handle1:CAS:528:DC%2BD2MXhtFWmtLbF Occurrence Handle17029087

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada-cho, Shinjiku-ku, Tokyo, 162-0054, Japan

    Masako Iwatani, Eisuke Inoue, Takahiro Nakamura, Ayako Nakajima, Masako Hara, Taisuke Tomatsu, Naoyuki Kamatani & Hisashi Yamanaka

Authors
  1. Masako Iwatani
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Eisuke Inoue
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Takahiro Nakamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ayako Nakajima
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Masako Hara
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Taisuke Tomatsu
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Naoyuki Kamatani
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Hisashi Yamanaka
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hisashi Yamanaka.

About this article

Cite this article

Iwatani, M., Inoue, E., Nakamura, T. et al. Efficacy profile of bucillamine in rheumatoid arthritis patients in a large observational cohort study, IORRA. Mod Rheumatol 16, 376–380 (2006). https://doi.org/10.1007/s10165-006-0527-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10165-006-0527-x

Key words

Search

Navigation