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Disability and patient’s appraisal of general health contribute to depressed mood in rheumatoid arthritis in a large clinical study in Japan

  • ORIGINAL ARTICLE
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Modern Rheumatology

Abstract

The aim of this study was to evaluate the factors responsible for depressed mood in rheumatoid arthritis (RA). Clinical and laboratory measures were collected from 4558 RA patients enrolled in a large clinical cohort study for RA conducted at the Institute of Rheumatology, Tokyo Women’s Medical University (IORRA study). A two-question depressed screening included in the U.S. Preventive Services Task Force recommendation were utilized to identify “depressed patients.” A total of 1875 (41.1%) were identified as “depressed patients” who presented with symptoms suggestive of depression. Patient’s Visual Analog Scale (VAS) for general health (43.3 mm vs 24.6 mm, P < 0.0001) and pain (40.9 mm vs 23.8 mm, P < 0.0001) and the disability index scores measured by the Health Association Questionnaire (HAQ) (0.986 vs 0.574, P < 0.0001) were significantly higher in depressed patients than in nondepressed patients. The presence of three or more comorbidities (odds ratio [OR] 2.157, P < 0.0001), infection (OR 1.754, P < 0.0001), and joint surgery (OR 1.878, P < 0.0001) were significantly correlated with depressed mood in RA. The results of the Generalized Linear Model analysis showed that HAQ disability index (P < 0.0001) and patient’s VAS for general health (P < 0.0001) were also strongly and significantly associated to the response variable “probability of depressed patients.’ Patient appraisal of poor general health and greater disability were associated with depressed mood in RA.

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Authors and Affiliations

  1. Institute of Rheumatology, Tokyo Women’s Medical University, 10-22 Kawada-cho, Shinjuku-ku, Tokyo, 162-0054, Japan

    Ayako Nakajima, Shigeo Kamitsuji, Akira Saito, Eiichi Tanaka, Taisuke Tomatsu, Masako Hara, Naoyuki Kamatani & Hisashi Yamanaka

  2. Department of Psychiatry, Tokyo Women’s Medical University, Tokyo, Japan

    Katsuji Nishimura & Naoshi Horikawa

  3. Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Norio Ozaki

Authors
  1. Ayako Nakajima
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  2. Shigeo Kamitsuji
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  3. Akira Saito
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  4. Eiichi Tanaka
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  5. Katsuji Nishimura
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  6. Naoshi Horikawa
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  7. Norio Ozaki
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  8. Taisuke Tomatsu
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  9. Masako Hara
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  10. Naoyuki Kamatani
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  11. Hisashi Yamanaka
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Corresponding author

Correspondence to Ayako Nakajima.

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Nakajima, A., Kamitsuji, S., Saito, A. et al. Disability and patient’s appraisal of general health contribute to depressed mood in rheumatoid arthritis in a large clinical study in Japan. Mod Rheumatol 16, 151–157 (2006). https://doi.org/10.1007/s10165-006-0475-5

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  • DOI: https://doi.org/10.1007/s10165-006-0475-5

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