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Beneficial effect of complementary alternative medicine on lymphedema with rheumatoid arthritis

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Modern Rheumatology

Abstract

Lymphedema of the limbs can be an added complication in a small number of rheumatoid arthritis cases, becoming a long-standing problem even when there is good control of inflammatory joint disease. In the present article, we describe a patient with RA who developed lymph-edema of the forearms successfully treated with TJ-48 (Juzentaihoto) as a complementary alternative medicine (CAM). This kind of edema does not seem to show any consistent relationship with the severity of arthritis in the literature surveyed. In contrast, lymphedema in this case improved in parallel with RA disease activity. We discuss the utility of CAM treatments and review the literature.

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References

  1. JL Kalliomaki M Vastamaki (1968) ArticleTitleChronic diffuse edema of the rheumatoid hand. A sign of local lymphatic involvement Ann Rheum Dis 27 167–9 Occurrence Handle5651232 Occurrence Handle1:STN:280:CCeB2c3ptVY%3D Occurrence Handle10.1136/ard.27.2.167

    Article  PubMed  CAS  Google Scholar 

  2. PDW Kiely JM Bland AEA Joseph PS Mortimer BE Bourke (1995) ArticleTitleUpper limb lymphatic function in inflammatory arthritis J Rheumatol 22 214–7 Occurrence Handle7738940 Occurrence Handle1:STN:280:ByqB2MjivVI%3D

    PubMed  CAS  Google Scholar 

  3. B Grillet J Dequeker (1987) ArticleTitleRheumatoid lymphedema J Rheumatol 14 1095–7 Occurrence Handle3509983 Occurrence Handle1:STN:280:BieC2c7hslc%3D

    PubMed  CAS  Google Scholar 

  4. JE Dacre DL Scott EC Huskisson (1990) ArticleTitleLymphoedema of the limbs as an extra-articular feature of rheumatoid arthritis Ann Rheum Dis 49 722–4 Occurrence Handle2241291 Occurrence Handle1:STN:280:By6D2MzjsVU%3D Occurrence Handle10.1136/ard.49.9.722

    Article  PubMed  CAS  Google Scholar 

  5. PDW Kiely AEA Joseph PS Mortimer BE Bourke (1994) ArticleTitleUpper limb lymphoedema associated with polyarthritis of rheumatoid type J Rheumatol 21 1043–5 Occurrence Handle7932412 Occurrence Handle1:STN:280:ByqD3MjovFE%3D

    PubMed  CAS  Google Scholar 

  6. A Niizawa T Kogure X Hai le H Fujinaga K Takahashi Y Shimada et al. (2003) ArticleTitleClinical and immunomodulatory effects of fun-boi, an herbal medicine, on collagen-induced arthritis in vivo Clin Exp Rheumatol 21 57–62 Occurrence Handle12673890 Occurrence Handle1:STN:280:DC%2BD3s7ls1eqtg%3D%3D

    PubMed  CAS  Google Scholar 

  7. X Hai le T Kogure A Niizawa H Fujinaga I Sakakibara Y Shimada et al. (2002) ArticleTitleSuppressive effect of hochu-ekki-to on collagen induced arthritis in DBA1J mice J Rheumatol 29 1601–8 Occurrence Handle12180716

    PubMed  Google Scholar 

  8. A Niizawa T Kogure H Fujinaga K Takahashi Y Shimada K Terasawa (2000) ArticleTitleClinical and immunomodulatory effect of fun-boi, an herbal medicine, in rheumatoid arthritis J Clin Rheumatol 6 244–9 Occurrence Handle10.1097/00124743-200010000-00002

    Article  Google Scholar 

  9. T Kogure T Itoh Y Shimada K Takahashi K Terasawa (1996) ArticleTitleThe influence of a traditional herbal medicine on the disease activity in patients with rheumatoid arthritis Clin Rheumatol Relat Res 8 233–41

    Google Scholar 

  10. A Kotaniemi H Isomaki M Hakala L Risteli J Risteli (1994) ArticleTitleIncreased Type I collagen degradation in early rheumatoid arthritis J Rheumatol 21 1593–6 Occurrence Handle7799334 Occurrence Handle1:STN:280:ByqD1MjivVU%3D

    PubMed  CAS  Google Scholar 

  11. M Sano S Okamoto T Yamawaki M Sakauchi T Meguro T Takita K Narushima N Suzuki (1997) ArticleTitleTwo cases of RS3PE syndrome (in Japanese) Ryeumachi 37 493–8 Occurrence Handle1:STN:280:ByiA1MbpsVY%3D

    CAS  Google Scholar 

  12. DM Mulherin O Fitzgerald B Bresnihan (1993) ArticleTitleLymphedema of the upper limb in patients with psoriatic arthritis Semin Arthritis Rheum 22 350–6 Occurrence Handle8511598 Occurrence Handle1:STN:280:ByyB1cbjs10%3D Occurrence Handle10.1016/S0049-0172(05)80013-7

    Article  PubMed  CAS  Google Scholar 

  13. KD Thornbury NG McHale JM Allen G Hughes (1990) ArticleTitleNerve-mediated contractions of sheep mesenteric lymph node capsules J Physiol 422 513–22 Occurrence Handle1972193 Occurrence Handle1:STN:280:By%2BB2sfotVA%3D

    PubMed  CAS  Google Scholar 

  14. JR Casley-Smith N Piller (1977) The mode of action of coumarin and related compounds in the treatment of edema L Clodius (Eds) Lymphedema Georg Thieme Stuttgart 33–41

    Google Scholar 

  15. RR Bruns GE Palade (1968) ArticleTitleStudies on blood capilllaries. II. Transport of ferittin molecules across the wall of muscle capillaries J Cell Biol 37 277–99 Occurrence Handle5656395 Occurrence Handle1:CAS:528:DyaF1cXktVWitb0%3D Occurrence Handle10.1083/jcb.37.2.277

    Article  PubMed  CAS  Google Scholar 

  16. C Salvarani (1995) ArticleTitleUpper limb lymphoedema in inflammatory arthropathy J Rheumatol 22 370 Occurrence Handle7738969 Occurrence Handle1:STN:280:ByqB2MjjtFE%3D

    PubMed  CAS  Google Scholar 

  17. BE Ostrov (2001) ArticleTitleBeneficial effect of etanercept on rheumatoid lymphedema Arthritis Rheum 44 240–1 Occurrence Handle10.1002/1529-0131(200101)44:1<240::AID-ANR32>3.0.CO;2-# Occurrence Handle11212167 Occurrence Handle1:STN:280:DC%2BD3M7ktFOqsw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  18. R Almodovar P Zarco FJ Quiros R Mazzucchelli (2004) ArticleTitleInfliximab treatment efficacy in lymphoedema associated with ankylosing spondylitis Rheumatology 43 1456 Occurrence Handle10.1093/rheumatology/keh341 Occurrence Handle15502003 Occurrence Handle1:STN:280:DC%2BD2crjtF2iug%3D%3D Occurrence Handle000225041300029

    Article  PubMed  CAS  ISI  Google Scholar 

  19. K Terasawa (1993) Introduction KAMPO Japanese-Oriental medicine; insights from clinical cases KK Standard McIntyre Tokyo 1–13

    Google Scholar 

  20. K Takahashi K Terasawa T Shimada T Mitsuma A Imadaya (1992) ArticleTitleA case of rheumatoid arthritis successfully treated with juzentaihoto (in Japanese) Kampo Med 42 43–7

    Google Scholar 

  21. T Kogure (2002) ArticleTitleBu Ji (Hozai): Kampo therapy for RA by decoction (in Japanese) Ryumachika 27 499–507

    Google Scholar 

  22. H Maruyama H Kawamura N Takemoto Y Komatsu M Aburada E Hosoya (1998) ArticleTitleEffect of Juzen-taiho-to on phagocytosis (in Japanese) Jpn J Inflamm 8 461–5

    Google Scholar 

  23. K Haranaka N Satomi A Sakurai R Haranaka N Okada M Kobayashi (1985) ArticleTitleAntitumor activities and tumor necrosis factor producibility of traditional Chinese medicines and crude drugs Cancer Immunol Immunother 20 1–5 Occurrence Handle10.1007/BF00199765 Occurrence Handle3851690 Occurrence Handle1:STN:280:BimD2Mzgsl0%3D

    Article  PubMed  CAS  Google Scholar 

  24. A Kubota S Okamura K Shimoda N Harada F Omori Y Niho (1992) ArticleTitleA traditional Chinese herbal medicine, juzen-taiho-to, augments the production of granulocyte/macrophage colony-stimulating factor from human peripheral blood mononuclear cells in vitro Int J Immunother 8 191–5

    Google Scholar 

  25. M Hamada Y Fujii H Yamamoto Y Miyazawa SM Shui YC Tung et al. (1988) ArticleTitleEffect of a kampo medicine, zyuzentaihoto, on the immune reactivity of tumor-bearing mice J Ethnopharma 24 311–20 Occurrence Handle1:STN:280:BiaA3M3ntFw%3D Occurrence Handle10.1016/0378-8741(88)90160-2

    Article  CAS  Google Scholar 

  26. Y Ohnishi H Fujii F Kimura T Mishima J Murata K Tazawa et al. (1996) ArticleTitleInhibitory effect of a traditional Chinese medicine, Juzen-taiho-to, on progressive growth of weakly malignant clone cells derived from murine fibrosarcoma Jpn J Cancer Res 87 1039–44 Occurrence Handle8957061 Occurrence Handle1:CAS:528:DyaK28XmsFGksb8%3D

    PubMed  CAS  Google Scholar 

  27. Y Ohnishi H Fujii Y Hayakawa R Sakukawa T Yamaura T Sakamoto et al. (1998) ArticleTitleOral administration of a Kampo (Japanese herbal) medicine Juzen-taiho-to inhibits liver metastasis of colon 26-L5 carcinoma cells Jpn J Cancer Res 89 206–13 Occurrence Handle9548449 Occurrence Handle1:CAS:528:DyaK1cXhs1yjsrg%3D

    PubMed  CAS  Google Scholar 

  28. H Kawamata H Ochiai N Mantani K Terasawa (2000) ArticleTitleEnhanced expression of inducible nitric oxide synthase by juzen-taiho-to in LPS-activated RAW264.7 cells, a murine macrophage cell line Am J Chinese Med 28 217–26 Occurrence Handle1:STN:280:DC%2BD3cvks1ylug%3D%3D Occurrence Handle10.1142/S0192415X0000026X

    Article  CAS  Google Scholar 

  29. T Kogure K Itoh T Tatsumi S Sekiya S Sakai Y Shimada et al. (2005) ArticleTitleThe effect of juzentaihoto/TJ-48 on the expression of killer-cell immunoglobulin-like receptors (CD158a/b) on peripheral lymphocytes: in vitro experiment Phytomedicine 12 327–32 Occurrence Handle10.1016/j.phymed.2004.05.002 Occurrence Handle15957365 Occurrence Handle1:STN:280:DC%2BD2MzgvF2hug%3D%3D Occurrence Handle000230192100001

    Article  PubMed  CAS  ISI  Google Scholar 

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Authors and Affiliations

  1. Department of Integrated Japanese Oriental Medicine, School of Medicine, Gunma University, 3-39-22 Showa-machi, Maebashi, 371-8511, Japan

    Toshiaki Kogure, Katsuhiko Ito, Hiroko Sato & Takeshi Tatsumi

  2. Department of General Practice Medicine, Graduate School of Medicine, Gunma University, Maebashi, Japan

    Ayami Hoshino, Yasuo Ohyama, Etsuo Kawata, Kin'ichi Fujita & Jun'ichi Tamura

Authors
  1. Toshiaki Kogure
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  2. Ayami Hoshino
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  3. Katsuhiko Ito
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  4. Hiroko Sato
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  5. Takeshi Tatsumi
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  6. Yasuo Ohyama
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  7. Etsuo Kawata
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  8. Kin'ichi Fujita
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  9. Jun'ichi Tamura
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Correspondence to Toshiaki Kogure.

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Kogure, T., Hoshino, A., Ito, K. et al. Beneficial effect of complementary alternative medicine on lymphedema with rheumatoid arthritis. Mod Rheumatol 15, 445–449 (2005). https://doi.org/10.1007/s10165-005-0438-2

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  • DOI: https://doi.org/10.1007/s10165-005-0438-2

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