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Validation of estimated glomerular filtration rate equations for Japanese children

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Clinical and Experimental Nephrology Aims and scope Submit manuscript

A Correction to this article was published on 03 December 2021

A Correction to this article was published on 24 August 2018

This article has been updated

Abstract

Background

The gold standard for evaluation of kidney function is renal inulin clearance (Cin). However, the methodology for Cin is complicated and difficult, especially for younger children and/or patients with bladder dysfunction. Therefore, we developed a simple and easier method for obtaining the estimated glomerular filtration rate (eGFR) using equations and values for several biomarkers, i.e., serum creatinine (Cr), serum cystatin C (cystC), serum beta-2 microglobulin (β2MG), and creatinine clearance (Ccr). The purpose of the present study was to validate these equations with a new data set.

Methods

To validate each equation, we used data of 140 patients with CKD with clinical need for Cin, using the measured GFR (mGFR). We compared the results for each eGFR equation with the mGFR using mean error (ME), root mean square error (RMSE), P30, and Bland–Altman analysis.

Results

The ME of Cr, cystC, β2MG, and Ccr based on eGFR was 15.8 ± 13.0, 17.2 ± 16.5, 15.4 ± 14.3, and 10.6 ± 13.0 ml/min/1.73 m2, respectively. The RMSE was 29.5, 23.8, 20.9, and 16.7, respectively. The P30 was 79.4, 71.1, 69.5, and 92.9%, respectively. The Bland–Altman bias analysis showed values of 4.0 ± 18.6, 5.3 ± 16.8, 12.7 ± 17.0, and 2.5 ± 17.2 ml/min/1.73 m2, respectively, for these parameters.

Conclusion

The bias of each eGFR equation was not large. Therefore, each eGFR equation could be used.

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Change history

  • 24 August 2018

    In the original publication, the author name was published incorrectly as “Riku Hamda”. The corrected name is given in this Correction.

  • 03 December 2021

    A Correction to this paper has been published: https://doi.org/10.1007/s10157-021-02144-2

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Author information

Authors and Affiliations

  1. Department of Pediatric Nephrology, Japanese Red Cross Nagoya Daini Hospital, 2-9 Myoken-cho Showa-ku, Nagoya, Aichi, 466-8650, Japan

    Yoshimitsu Gotoh

  2. Department of Clinical Medicine, Japanese Red Cross Toyota College of Nursing, 12-33 Nanamagari, Hakusan-cho, Toyota, Aichi, 471-8565, Japan

    Osamu Uemura

  3. Department of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan

    Kenji Ishikura

  4. Department of Pediatrics, Shiga University of Medical Science, Seta, Ootsu, Shiga, 520-2192, Japan

    Tomoyuki Sakai

  5. Department of Pediatric Nephrology, Toho University Faculty of Medicine, 6-11-1 Oomori Nishi Seta, Ootsu, Shiga, 143-8541, Japan

    Yuko Hamasaki

  6. Department of Pediatrics, Hokkaido Medical Center, 5-7-1-1 Yamanote 5jyo Nishi-ku, Sapporo, Hokkaido, 063-0005, Japan

    Yoshinori Araki

  7. Department of Nephrology, Tokyo Metropolitan Children’s Medical Center, 2-8-29 Musasidai, Futyu-shi, Tokyo, Tokyo, 183-8561, Japan

    Riku Hamda & Masataka Honda

Authors
  1. Yoshimitsu Gotoh
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  2. Osamu Uemura
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  3. Kenji Ishikura
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  4. Tomoyuki Sakai
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  5. Yuko Hamasaki
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  6. Yoshinori Araki
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  7. Riku Hamda
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  8. Masataka Honda
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Consortia

On behalf of the Pediatric CKD Study Group in Japan in conjunction with the Committee of Measures for Pediatric CKD of the Japanese Society of Pediatric Nephrology

Corresponding author

Correspondence to Yoshimitsu Gotoh.

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Conflict of interest

The authors have declared that no conflict of interest exists.

Human and animal rights

All procedures involving human participants were in accordance with ethical standards of the institution at which the studies were conducted (Approval Number in Japanese Red Cross Nagoya Daini Hospital 1065), and with standards of the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Written informed consent was not obtained, because of use of retrospective data for clinical use. This information is noted on the website (opt-out).

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Cite this article

Gotoh, Y., Uemura, O., Ishikura, K. et al. Validation of estimated glomerular filtration rate equations for Japanese children. Clin Exp Nephrol 22, 931–937 (2018). https://doi.org/10.1007/s10157-018-1529-7

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  • DOI: https://doi.org/10.1007/s10157-018-1529-7

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