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Association of arginine vasopressin surrogate marker urinary copeptin with severity of autosomal dominant polycystic kidney disease (ADPKD)

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Abstract

Background

Experimental studies suggest a detrimental role for cyclic adenosine monophosphate (cAMP) and vasopressin in the pathogenesis of autosomal dominant polycystic kidney disease (ADPKD). It is unknown, however, whether urinary cAMP and copeptin concentration are associated with disease severity in patients with ADPKD.

Methods

Urinary cAMP (u-cAMP) and copeptin concentration (u-copeptin) were measured by immunoassay in ADPKD patients with CKD stage ≤4. We compared our measurements with clinical parameters including estimated glomerular filtration rate (eGFR), total kidney volume (TKV), and height-adjusted TKV (htTKV). Logarithmic transformation of all variables was performed to fulfill the requirement of equal distribution of the residuals.

Results

We included 50 patients in this study (24 females and 26 males; mean age: 49.3 years). The median eGFR and TKV were 53.2 ml/min/1.73 m2 (interquartile range: IQR; 29.4–68.45) and 1138.1 ml (IQR; 814.7–2065.0), respectively. The median u-copeptin level was 12.19 (IQR; 6.91–22.32) ng/ml. Although u-cAMP/u-Cr was not significantly correlated with TKV (R = −0.006, p = 0.967) and eGFR (R = 0.077, p = 0.602), urinary copeptin/u-Cr was statistically associated with the various markers of disease severity in ADPKD [positively with TKV (R = 0.351, p = 0.014), htTKV (R = 0.383, p = 0.008) and negatively with eGFR (R = −0.304, p = 0.036)].

Conclusions

In ADPKD subjects, a higher u-copeptin is associated with disease progression, suggesting that u-copeptin may be a new surrogate marker to predict renal prognosis in ADPKD.

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Acknowledgments

This work was supported in part by a grant for the Progressive Renal Diseases Research Project from the Ministry of Health, Labour and Welfare of Japan.

Conflict of interest

Honoraria: Satoru Muto, Shigeo Horie (Otsuka Pharmaceutical); Subsidies or Donations: Satoru Muto, Haruna Kawano, Shigeo Horie (Otsuka Pharmaceutical); Endowed departments by commercial entities: Shigeo Horie (Otsuka Pharmaceutical); Travel fees, gifts, and others: Satoru Muto, Shigeo Horie (Otsuka Pharmaceutical).

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Authors and Affiliations

  1. Department of Urology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-Ku, Tokyo, 173-8605, Japan

    Akiko Nakajima, Yan Lu & Satoru Muto

  2. Department of Urology, Graduate School of Medicine, Juntendo University, Tokyo, Japan

    Haruna Kawano & Shigeo Horie

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  1. Akiko Nakajima
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  2. Yan Lu
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  3. Haruna Kawano
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Correspondence to Satoru Muto.

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Nakajima, A., Lu, Y., Kawano, H. et al. Association of arginine vasopressin surrogate marker urinary copeptin with severity of autosomal dominant polycystic kidney disease (ADPKD). Clin Exp Nephrol 19, 1199–1205 (2015). https://doi.org/10.1007/s10157-015-1101-7

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  • DOI: https://doi.org/10.1007/s10157-015-1101-7

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