Skip to main content

Advertisement

SpringerLink
Log in

Distribution of Streptococcus mutans strains with collagen-binding proteins in the oral cavity of IgA nephropathy patients

  • Original Article
  • Published:
Clinical and Experimental Nephrology Aims and scope Submit manuscript

Abstract

Background

IgA nephropathy (IgAN) is the most common primary chronic glomerulonephritis; however, its precise initiating pathogenesis remains unclear. Streptococcus mutans is a major pathogen of human dental caries. S. mutans strains with the cnm gene encoding Cnm, a collagen-binding protein, have been reported to contribute to the development of systemic diseases. However, the contribution of S. mutans with Cnm in the development of IgAN has not been reported. The aim of this study was to investigate the prevalence of cnm-positive S. mutans in IgAN patients and clarify the effects of cnm-positive S. mutans on the histological pathology of IgAN.

Methods

We identified the cnm gene in S. mutans isolated in saliva specimens, which were collected from IgAN patients (n = 53) and control subjects (n = 50). We evaluated the collagen-binding properties of S. mutans in IgAN patients and controls. The clinical parameters and histological scores were also assessed in IgAN patients.

Results

The rates of S. mutans isolation in IgAN and control groups were 84.0 and 84.9 %, respectively, not significantly dfferent. cnm-positive strains were significantly more prevalent in the IgAN group than in controls (32.1 vs. 14.0 %, p < 0.05). With regard to collagen-binding assays, the binding rates of cnm-positive strains were significantly higher in the IgAN group than in controls (96.6 vs. 30.0, p < 0.05). In addition, the segmental glomerulosclerosis scores were significantly higher in cnm-positive patients with IgAN than in cnm-negative patients with IgAN (0.94 vs. 0.57, p < 0.05).

Conclusion

cnm-positive S. mutans strains are potentially associated with the pathogenesis of IgAN.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. D’Amico G. The commonest glomerulonephritis in the world: IgA nephropathy. Q J Med. 1987;64(245):709–27.

    PubMed  Google Scholar 

  2. Julian BA, Waldo FB, Rifai A, et al. IgA nephropathy, the most common glomerulonephritis worldwide. A neglected disease in the United States? Am J Med. 1988;84(1):129–32.

    Article  CAS  PubMed  Google Scholar 

  3. Wyatt RJ, Julian BA. IgA nephropathy. N Engl J Med. 2013;368(25):2402–14.

    Article  CAS  PubMed  Google Scholar 

  4. Donadio JV, Grande JP. IgA nephropathy. N Engl J Med. 2002;347(10):738–48.

    Article  CAS  PubMed  Google Scholar 

  5. Suzuki S, Nakatomi Y, Sato H, et al. Haemophilus parainfluenzae antigen and antibody in renal biopsy samples and serum of patients with IgA nephropathy. Lancet. 1994;343:12–6.

    Article  CAS  PubMed  Google Scholar 

  6. Kusano K, Tokunaga O, Ando T, et al. Helicobacter pylori in the palatine tonsils of patients with IgA nephropathy compared with those of patients with recurrent pharyngotonsillitis. Hum Pathol. 2007;38(12):1788–97.

    Article  PubMed  Google Scholar 

  7. Iwama H, Horikoshi S, Shirato I, et al. Epstein-Barr virus detection in kidney biopsy specimens correlates with glomerular mesangial injury. Am J Kidney Dis. 1998;32(5):785–93.

    Article  CAS  PubMed  Google Scholar 

  8. Nagasawa Y, Iio K, Fukuda S, et al. Periodontal disease bacteria specific to tonsil in IgA nephropathy patients predicts the remission by the treatment. PLoS One. 2014;9(1):e81636.

    Article  PubMed Central  PubMed  Google Scholar 

  9. Kojima A, Nakano K, Wada K, et al. Infection of specific strains of Streptococcus mutans, oral bacteria, confers a risk of ulcerative colitis. Sci Rep. 2012;2:332.

    Article  PubMed Central  PubMed  Google Scholar 

  10. Nomura R, Naka S, Nemoto H, et al. Potential high virulence for infective endocarditis in Streptococcus mutans strains with collagen-binding proteins but lacking PA expression. Arch Oral Biol. 2013;58(11):1627–34.

    Article  CAS  PubMed  Google Scholar 

  11. Nakano K, Hokamura K, Taniguchi N, et al. The collagen-binding protein of Streptococcus mutans is involved in haemorrhagic stroke. Nat Commun. 2011;2:485.

    Article  PubMed Central  PubMed  Google Scholar 

  12. Nakano K, Nomura R, Nakagawa I, et al. Demonstration of Streptococcus mutans with a cell wall polysaccharide specific to a new serotype, k, in the human oral cavity. J Clin Microbiol. 2004;42(1):198–202.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  13. Hoshino T, Kawaguchi M, Shimizu N, et al. PCR detection and identification of oral streptococci in saliva samples using gtf genes. Diagn Microbiol Infect Dis. 2004;48(3):195–9.

    Article  CAS  PubMed  Google Scholar 

  14. Waterhouse JC, Russell RR. Dispensable genes and foreign DNA in Streptococcus mutans. Microbiology. 2006;152(Pt 6):1777–88.

    Article  CAS  PubMed  Google Scholar 

  15. Nomura R, Nakano K, Taniguchi N, et al. Molecular and clinical analyses of the gene encoding the collagen-binding adhesin of Streptococcus mutans. J Med Microbiol. 2009;58(Pt 4):469–75.

    Article  CAS  PubMed  Google Scholar 

  16. Park KS, Han SH, Kie JH, et al. Comparison of the Haas and the Oxford classifications for prediction of renal outcome in patients with IgA nephropathy. Hum Pathol. 2014;45(2):236–43.

    Article  CAS  PubMed  Google Scholar 

  17. Roberts IS, Cook HT, Troyanov S, et al. The Oxford classification of IgA nephropathy: pathology definitions, correlations, and reproducibility. Kidney Int. 2009;76(5):546–56.

    Article  PubMed  Google Scholar 

  18. Cattran DC, Coppo R, Cook HT, et al. The Oxford classification of IgA nephropathy: rationale, clinicopathological correlations, and classification. Kidney Int. 2009;76(5):534–45.

    Article  PubMed  Google Scholar 

  19. Lee H, Yi SH, Seo MS, et al. Validation of the Oxford classification of IgA nephropathy: a single-center study in Korean adults. Korean J Intern Med. 2012;27(3):293–300.

    Article  PubMed Central  PubMed  Google Scholar 

  20. Sato Y, Okamoto K, Kagami A, et al. Streptococcus mutans strains harboring collagen-binding adhesin. J Dent Res. 2004;83(7):534–9.

    Article  CAS  PubMed  Google Scholar 

  21. Nakano K, Lapirattanakul J, Nomura R, et al. Streptococcus mutans clonal variation revealed by multilocus sequence typing. J Clin Microbiol. 2007;45(8):2616–25.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  22. Kokubo T, Hiki Y, Iwase H, et al. Protective role of IgA1 glycans against IgA1 self-aggregation and adhesion to extracellular matrix proteins. J Am Soc Nephrol. 1998;9(11):2048–54.

    CAS  PubMed  Google Scholar 

  23. Narita I, Gejyo F. Pathogenetic significance of aberrant glycosylation of IgA1 in IgA nephropathy. Clin Exp Nephrol. 2008;12:332–8.

    Article  CAS  PubMed  Google Scholar 

  24. Abrahamson, St John PL, Stroganova L, et al. Laminin and type IV collagen isoform substitutions occur in temporally and spatially distinct patterns in developing kidney glomerular basement membranes. J Histochem Cytochem. 2013;61(10):706–18.

    Article  PubMed Central  PubMed  Google Scholar 

  25. Albini B, Nisengard RJ, Glurich I, et al. Streptococcus mutans-induced nephritis in rabbits. Am J Pathol. 1985;118(3):408–18.

    PubMed Central  CAS  PubMed  Google Scholar 

  26. Miyata M, Glurich I, Kasukawa R, et al. Streptococcus mutans-induced nephritis in rabbits: rheumatoid factors and nephritogenicity. Int Arch Allergy Immunol. 1995;108(4):360–7.

    Article  CAS  PubMed  Google Scholar 

  27. Lapirattanakul J, Nakano K. Mother-to-child transmission of mutans streptococci. Future Microbiol. 2014;9:807–23.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

The authors thank Prof. Howard K. Kuramitsu, State University of New York at Buffalo, for editing the manuscript. This study was supported by Osaka University Graduate School of Dentistry.

Conflict of interest

The authors state that they have no conflict of interest (COI).

Author information

Authors and Affiliations

  1. Division of Nephrology, Seirei Hamamatsu General Hospital, 2-12-12 Sumiyoshi, Naka-ku, Hamamatsu, Shizuoka, 430-8558, Japan

    Taro Misaki, Tempei Shiooka, Yoshitaka Naito, Yumiko Suzuki & Taisuke Isozaki

  2. Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, Osaka, Japan

    Shuhei Naka, Keiko Kuroda, Ryota Nomura & Kazuhiko Nakano

  3. First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan

    Hideo Yasuda

Authors
  1. Taro Misaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shuhei Naka
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Keiko Kuroda
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ryota Nomura
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Tempei Shiooka
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yoshitaka Naito
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yumiko Suzuki
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Hideo Yasuda
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Taisuke Isozaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Kazuhiko Nakano
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Taro Misaki.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Misaki, T., Naka, S., Kuroda, K. et al. Distribution of Streptococcus mutans strains with collagen-binding proteins in the oral cavity of IgA nephropathy patients. Clin Exp Nephrol 19, 844–850 (2015). https://doi.org/10.1007/s10157-014-1072-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10157-014-1072-0

Keywords

Search

Navigation