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Neutrophil gelatinase-associated lipocalin levels associated with cardiovascular disease in chronic kidney disease patients

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Abstract

Background

Elevated levels of neutrophil gelatinase-associated lipocalin (NGAL) have been reported in patients with cardiovascular disease (CVD), heart failure, and stroke. We assessed the relationships between serum levels of NGAL and the prevalence of CVD, and clarified the prognostic usefulness of systemic NGAL levels in hemodialysis (HD) patients.

Methods

Eighty-eight HD patients were followed up for 1 year. Logistic regression analyses were used to investigate the relationship between de novo CVD status and NGAL levels as well as other risk factors.

Results

During follow-up, CVD events occurred in 20 patients. Initial serum levels of NGAL and brain natriuretic peptide of HD patients with de novo CVD were significantly higher than those of HD patients without de novo CVD. Multivariate logistic regression analyses showed that initial serum levels of NGAL were independent risk factors for de novo CVD in HD patients. When patients were classified on the basis of NGAL quartiles, multiple logistic regression analyses demonstrated that the highest quartile of NGAL level showed an increased odds ratio for the prevalence of CVD.

Conclusion

These findings suggest that NGAL levels can be used to detect the prevalence of CVD in HD patients with or without diabetes.

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Acknowledgments

We thank Miyo Iino, Etuko Natori, and the staff of Haraguchi Clinic for their efforts in collecting serum samples as well as the measurement of the ABI and CAVI.

Conflict of interest

There was no conflict of interest that could be perceived as prejudicing the impartiality of the research reported here.

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Authors and Affiliations

  1. Third Department of Internal Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan

    Fumihiko Furuya, Kazuya Takahashi, Daiichiro Akiyama, Chikako Asakawa, Ayako Okamura & Tetsuro Kobayashi

  2. Department of Laboratory Medicine, Fukushima Medical University, Fukushima, Japan

    Hiroki Shimura

  3. Department of Health Sciences, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan

    Hiroshi Yokomichi & Zentaro Yamagata

  4. Haraguchi Clinic, Yamanashi, Japan

    Ai Motosugi & Kazutaka Haraguchi

Authors
  1. Fumihiko Furuya
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  2. Hiroki Shimura
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  4. Kazuya Takahashi
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  9. Kazutaka Haraguchi
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  11. Tetsuro Kobayashi
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Corresponding author

Correspondence to Fumihiko Furuya.

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Furuya, F., Shimura, H., Yokomichi, H. et al. Neutrophil gelatinase-associated lipocalin levels associated with cardiovascular disease in chronic kidney disease patients. Clin Exp Nephrol 18, 778–783 (2014). https://doi.org/10.1007/s10157-013-0923-4

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  • DOI: https://doi.org/10.1007/s10157-013-0923-4

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