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Stiffness parameter β as a predictor of the 4-year all-cause mortality of chronic hemodialysis patients

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Abstract

Background

There is a lack of information on stiffness parameter β, an index of arterial stiffness, in hemodialysis (HD) patients. The aim of the present study was to investigate whether stiffness parameter β is predictive of the long-term mortality of chronic HD patients.

Methods

We measured biochemical parameters and the stiffness parameter β of 80 patients on maintenance HD therapy and followed their course for 4 years, and we enrolled 70 of these 80 patients in the study. We divided the 70 patients into tertiles according to their stiffness parameter β values, and conducted multivariate analyses to examine the impact of the tertiles on 4-year mortality.

Results

Older age and the presence of diabetes mellitus were found to be independently associated with higher stiffness parameter β values. Fifteen patients (21.4 %) died and 16 (22.9 %) experienced a new cardiovascular event during the follow-up period. The results of a Kaplan–Meier analysis revealed a significantly higher risk of all-cause mortality in the HD patients with highest stiffness parameter β values (p = 0.0106). According to the ROC curve, the cut-off level that yielded maximal sensitivity and specificity for predicting all-cause mortality was 10.1, and the sensitivity and specificity using the cut-off value were 69.2 and 70.2 %, respectively.

Conclusion

The results of this study suggest that stiffness parameter β is a predictor of all-cause mortality in chronic HD patients.

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Acknowledgments

We thank all staff of the Dialysis Unit in Hidaka Hospital for their technical assistance. The study was supported by grants from the Japan Research Promotion Society for Cardiovascular Diseases.

Conflict of interest

We have no conflict of interest to disclose.

Author information

Authors and Affiliations

  1. Department of Medicine, Kidney Center, Tokyo Women’s Medical University, Tokyo, Japan

    Masayo Sato & Kosaku Nitta

  2. Department of Medicine, Medical Center East, Tokyo Women’s Medical University, Tokyo, Japan

    Masayo Sato, Tetsuya Ogawa & Kuniaki Otsuka

  3. Hidaka Hospital, Gunma, Japan

    Yoshitaka Ando

Authors
  1. Masayo Sato
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  2. Tetsuya Ogawa
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  3. Kuniaki Otsuka
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  4. Yoshitaka Ando
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  5. Kosaku Nitta
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Corresponding author

Correspondence to Kosaku Nitta.

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Sato, M., Ogawa, T., Otsuka, K. et al. Stiffness parameter β as a predictor of the 4-year all-cause mortality of chronic hemodialysis patients. Clin Exp Nephrol 17, 268–274 (2013). https://doi.org/10.1007/s10157-012-0674-7

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  • DOI: https://doi.org/10.1007/s10157-012-0674-7

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