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Performance of the Japanese GFR equation in potential kidney donors

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Clinical and Experimental Nephrology Aims and scope Submit manuscript

Abstract

Background

Japanese GFR equation was developed from mainly chronic kidney disease (CKD) subjects. Only a small number of healthy subjects were included in the development and validation of the GFR equation. We assessed the performance of the equation in potential kidney donors.

Methods

A total of 113 potential kidney donors was included. The data of CKD subjects that were previously reported were also included for comparison. GFR (mGFR) was measured by inulin clearance. The estimated GFR (eGFR) was calculated by the Japanese GFR equation. Bias of the equation (eGFR − mGFR) and urinary creatinine excretion were evaluated.

Results

There was no significant difference between eGFR and mGFR in 340 CKD subjects (54.2 ± 31.6 and 55.7 ± 33.2 ml/min/1.73 m2, respectively). Contrarily, the eGFR was significantly lower than mGFR in 113 potential kidney donors (78.9 ± 16.2 and 93.6 ± 19.2 ml/min/1.73 m2, respectively). The biases in potential kidney donors with eGFR 30–59 and 60–89 ml/min/1.73 m2 were significantly greater than those in CKD subjects (−19.2 ± 12.2 and −18.3 ± 16.4 ml/min/1.73 m2 in potential kidney donors and −3.8 ± 15.6 and −3.4 ± 17.6 ml/min/1.73 m2 in CKD subjects, respectively). Creatinine excretion per body weight of potential kidney donors was significantly higher than that of CKD subjects, suggesting higher creatinine generation in potential kidney donors.

Conclusion

The Japanese GFR equation underestimated GFR in potential kidney donors. Higher creatinine generation compared with CKD subjects may contribute to the underestimation of GFR by the Japanese GFR equation in potential kidney donors.

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Acknowledgments

The following investigators participated in the present study: Kazunari Tanabe (Tokyo Women’s Medical University), Hideki Ishida (Tokyo Women’s Medical University), Hattori Motoshi (Tokyo Women’s Medical University), Chikamoto Hiroko (Tokyo Women’s Medical University), Keiko Uchida (Tokyo Women’s Medical University), Atsushi Aikawa (Toho University), Ken Sakai (Toho University), Kazuhide Saito (Niigata University), Kunio Morozumi (Japanese Red Cross Nagoya Daini Hospital), Norihiko Goto (Japanese Red Cross Nagoya Daini Hospital), Schoichi Maruyama (Nagoya University), Yasuhiro Okabe (Kyushu University), Yoshifumi Miura (Kyushu University), Kei Kurihara (Kyushu University), Soushi Terasaka (Kyushu University), Sayako Kawanami (Kyushu University), Kohsuke Masutani (Kyushu University), Toshiaki Nakano (Kyushu University), Akihiro Tsuchimoto (Kyushu University) and Akiko Fujisaki (Kyushu University). This study was supported in part by a grant from the Japanese Society of Nephrology and a Health and Labor Sciences Research Grant from the Ministry of Health, Labor and Welfare on Renal Research, Japan.

Conflict of interest

All the authors have declared no competing interest.

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Authors and Affiliations

  1. Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Suita, Osaka, 565-0871, Japan

    Masaru Horio

  2. Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Yoshinari Yasuda, Enyu Imai & Seiichi Matsuo

  3. Departments of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan

    Jyunya Kaimori & Yoshitaka Isaka

  4. Department of Specific Organ Regulation, Osaka University Graduate School of Medicine, Osaka, Japan

    Naotsugu Ichimaru

  5. Department of Advanced Technology for Transplantation, Osaka University Graduate School of Medicine, Osaka, Japan

    Shiro Takahara

  6. Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, Kobe, Japan

    Shinichi Nishi

  7. Department of Transplantation and Endocrine Surgery, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Japan

    Kazuharu Uchida

  8. Department of Nephrology, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Japan

    Asami Takeda

  9. Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Ryohei Hattori

  10. Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Hidehisa Kitada

  11. Department of Integrated Therapy for Chronic Kidney Disease, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Kazuhiko Tsuruya

  12. Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medicine and Dental Science, Niigata, Japan

    Kota Takahashi

  13. Third Department of Medicine, Fukushima Medical University, Fukushima, Japan

    Tsuyoshi Watanabe

Authors
  1. Masaru Horio
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  2. Yoshinari Yasuda
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  3. Jyunya Kaimori
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  4. Naotsugu Ichimaru
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  5. Yoshitaka Isaka
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  6. Shiro Takahara
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  7. Shinichi Nishi
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  8. Kazuharu Uchida
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  9. Asami Takeda
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  10. Ryohei Hattori
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  11. Hidehisa Kitada
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  12. Kazuhiko Tsuruya
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  13. Enyu Imai
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  14. Kota Takahashi
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  15. Tsuyoshi Watanabe
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  16. Seiichi Matsuo
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Corresponding author

Correspondence to Masaru Horio.

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Cite this article

Horio, M., Yasuda, Y., Kaimori, J. et al. Performance of the Japanese GFR equation in potential kidney donors. Clin Exp Nephrol 16, 415–420 (2012). https://doi.org/10.1007/s10157-012-0586-6

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  • DOI: https://doi.org/10.1007/s10157-012-0586-6

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