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A case of idiopathic nodular glomerulosclerosis with fibrin caps

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Abstract

We report a case of idiopathic nodular glomerulosclerosis (ING) mimicking diabetic Kimmelstiel–Wilson glomerulopathy. A 72-year-old man suffering from nephritic syndrome and renal dysfunction had no prior history of diabetes mellitus, but had impaired glucose tolerance and a history of hypertension and smoking. A kidney biopsy showed increased mesangial matrix with Kimmelstiel–Wilson-like nodules, glomerular basement membrane thickening and capillary microaneurysms. Additionally, a large amount of fibrin caps detectable as electron-dense subendothelial material by electron microscopy were observed. Although ING with fibrin caps has been rarely reported, the large number of fibrin caps seen in this case may be due to the advanced clinical stage.

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Authors and Affiliations

  1. Division of Nephrology, Kyoto Min-Iren Chuo Hospital, 16-1 Kasuga-cho, Nishinokyo, Nakagyo-ku, Kyoto, 604-8453, Japan

    Chiharu Kinoshita, Yoshimoto Inoue, Yoko Kanda & Chiaki Kanda

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  1. Chiharu Kinoshita
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  2. Yoshimoto Inoue
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  3. Yoko Kanda
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  4. Chiaki Kanda
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Correspondence to Chiharu Kinoshita.

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Kinoshita, C., Inoue, Y., Kanda, Y. et al. A case of idiopathic nodular glomerulosclerosis with fibrin caps. Clin Exp Nephrol 15, 937–941 (2011). https://doi.org/10.1007/s10157-011-0513-2

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  • DOI: https://doi.org/10.1007/s10157-011-0513-2

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