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Significance of past history of renal failure for the detection of high-risk individuals for cardiovascular and end-stage renal disease: analysis of data from a nationwide health checkup

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Abstract

Background

Clinical information regarding risk factors may be helpful in the detection of various diseases. This cross-sectional study examined the characteristics of subjects with past history of renal failure, and assessed whether this information would be useful for the efficient detection of high-risk individuals for chronic kidney disease (CKD) and cardiovascular disease (CVD) at health checkup.

Methods

This study utilized data from a nationwide health checkup, “The Specific Health Check and Guidance in Japan,” and data for 250,130 adult subjects were analyzed. Subjects with self-reported history of renal failure and receiving dialysis therapy were defined as having a history of renal failure.

Results

Among total participants, there were 1,400 (0.6%) with a history of renal failure. The prevalence of a history of renal failure was higher in subjects with CKD than in those without CKD (1.5 vs. 0.3%, P < 0.001) and increased with progression of the stage of CKD (0.9–43.5%). Subjects with a history of renal failure had a reduced estimated glomerular filtration rate (44.6 ± 20.3 ml/min/1.73 m2) and a higher prevalence of CKD (50.5%) and CVD (31.9%), compared with subjects with hypertension, diabetes or metabolic syndrome. Multivariate logistic regression analysis showed an independent association between a history of CVD and renal failure (odds ratio 3.68, 95% confidence interval 3.26–4.15), after adjustment for confounding factors.

Conclusions

A history of renal failure was strongly associated with advanced CKD and CVD. Information regarding history of renal failure could be utilized to efficiently detect high-risk individuals at health checkup.

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References

  1. Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med. 2004;351:1296–305.

    Article  PubMed  CAS  Google Scholar 

  2. Kiberd BA, Jindal KK. Screening to prevent renal failure in insulin dependent diabetic patients: an economic evaluation. BMJ. 1995;311:1595–9.

    Article  PubMed  CAS  Google Scholar 

  3. Boulware LE, Jaar BG, Tarver-Carr ME, Brancati FL, Powe NR. Screening for proteinuria in US adults: a cost-effectiveness analysis. JAMA. 2003;290:3101–14.

    Article  PubMed  CAS  Google Scholar 

  4. Jolly SE, Burrows NR, Chen SC, Li S, Jurkovitz CT, Narva AS, et al. Racial and ethnic differences in albuminuria in individuals with estimated GFR greater than 60 mL/min/1.73 m2: results from the Kidney Early Evaluation Program (KEEP). Am J Kidney Dis. 2010;55:S15–22.

    Article  PubMed  CAS  Google Scholar 

  5. McClellan W, Speckman R, McClure L, Howard V, Campbell RC, Cushman M, et al. Prevalence and characteristics of a family history of end-stage renal disease among adults in the United States population: Reasons for Geographic and Racial Differences in Stroke (REGARDS) renal cohort study. J Am Soc Nephrol. 2007;18:1344–52.

    Article  PubMed  CAS  Google Scholar 

  6. Brown WW, Peters RM, Ohmit SE, Keane WF, Collins A, Chen SC, et al. Early detection of kidney disease in community settings: the Kidney Early Evaluation Program (KEEP). Am J Kidney Dis. 2003;42:22–35.

    Article  PubMed  Google Scholar 

  7. Committee to Evaluate Diagnostic Standards for Metabolic Syndrome. Definition and the diagnostic standard for metabolic syndrome (in Japanese). Nippon Naika Gakkai Zasshi. 2005;94:794–809.

    Article  Google Scholar 

  8. Matsuo S, Imai E, Horio M, Yasuda Y, Tomita K, Nitta K, et al. Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis. 2009;53:982–92.

    Article  PubMed  CAS  Google Scholar 

  9. Levey AS, Eckardt KU, Tsukamoto Y, Levin A, Coresh J, Rossert J, et al. Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int. 2005;67:2089–100.

    Article  PubMed  Google Scholar 

  10. Coresh J, Byrd-Holt D, Astor BC, Briggs JP, Eggers PW, Lacher DA, et al. Chronic kidney disease awareness, prevalence, and trends among U.S. adults, 1999 to 2000. J Am Soc Nephrol. 2005;16:180–8.

    Article  PubMed  Google Scholar 

  11. Cirillo M, Laurenzi M, Mancini M, Zanchetti A, Lombardi C, De Santo NG. Low glomerular filtration in the population: prevalence, associated disorders, and awareness. Kidney Int. 2006;70:800–6.

    Article  PubMed  CAS  Google Scholar 

  12. Grams ME, Astor BC, Bash LD, Matsushita K, Wang Y, Coresh J. Albuminuria and estimated glomerular filtration rate independently associate with acute kidney injury. J Am Soc Nephrol. 2010;21:1757–64.

    Article  PubMed  CAS  Google Scholar 

  13. Japanese Society of Nephrology. Evidence-based practice guideline for the treatment of CKD. Clin Exp Nephrol. 2009;13:537–66.

    Article  Google Scholar 

  14. Minutolo R, De Nicola L, Mazzaglia G, Postorino M, Cricelli C, Mantovani LG, et al. Detection and awareness of moderate to advanced CKD by primary care practitioners: a cross-sectional study from Italy. Am J Kidney Dis. 2008;52:444–53.

    Article  PubMed  Google Scholar 

  15. Muntner P, Anderson A, Charleston J, Chen Z, Ford V, Makos G, et al. Hypertension awareness, treatment, and control in adults with CKD: results from the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis. 2010;55:441–51.

    Article  PubMed  CAS  Google Scholar 

  16. Ishani A, Xue JL, Himmelfarb J, Eggers PW, Kimmel PL, Molitoris BA, et al. Acute kidney injury increases risk of ESRD among elderly. J Am Soc Nephrol. 2009;20:223–8.

    Article  PubMed  Google Scholar 

  17. Wald R, Quinn RR, Luo J, Li P, Scales DC, Mamdani MM, et al. Chronic dialysis and death among survivors of acute kidney injury requiring dialysis. JAMA. 2009;302:1179–85.

    Article  PubMed  CAS  Google Scholar 

  18. Lafrance JP, Djurdjev O, Levin A. Incidence and outcomes of acute kidney injury in a referred chronic kidney disease cohort. Nephrol Dial Transplant. 2010;25:2203–9.

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

This work was supported by Health and Labour Sciences Research Grants for “Research on the Positioning of Chronic Kidney Disease (CKD) in Specific Health Check and Guidance in Japan” (20230601), the Ministry of Health, Labour and Welfare of Japan.

Conflict of interest

None of the authors has a conflict of interest to declare.

Author information

Authors and Affiliations

  1. Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata, 990-9585, Japan

    Kazunobu Ichikawa, Tsuneo Konta & Ami Ikeda

  2. Dialysis Division, University of Miyazaki Hospital, Miyazaki, Japan

    Shouichi Fujimoto

  3. Steering Committee for the “Research on the Positioning of Chronic Kidney Disease (CKD) in Specific Health Check and Guidance in Japan”, Otawara, Japan

    Kunitoshi Iseki, Toshiki Moriyama, Kunihiro Yamagata, Kazuhiko Tsuruya, Hideaki Yoshida, Koichi Asahi & Tsuyoshi Watanabe

  4. Department of Biostatistics/Epidemiology and Preventive Health Sciences, School of Health Sciences and Nursing, University of Tokyo, Tokyo, Japan

    Issei Kurahashi & Yasuo Ohashi

Authors
  1. Kazunobu Ichikawa
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  2. Tsuneo Konta
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  3. Ami Ikeda
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  4. Shouichi Fujimoto
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  5. Kunitoshi Iseki
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  6. Toshiki Moriyama
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  7. Kunihiro Yamagata
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  8. Kazuhiko Tsuruya
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  9. Hideaki Yoshida
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  10. Koichi Asahi
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  11. Issei Kurahashi
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  12. Yasuo Ohashi
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  13. Tsuyoshi Watanabe
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Corresponding author

Correspondence to Tsuneo Konta.

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Ichikawa, K., Konta, T., Ikeda, A. et al. Significance of past history of renal failure for the detection of high-risk individuals for cardiovascular and end-stage renal disease: analysis of data from a nationwide health checkup. Clin Exp Nephrol 15, 841–847 (2011). https://doi.org/10.1007/s10157-011-0509-y

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  • DOI: https://doi.org/10.1007/s10157-011-0509-y

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