Skip to main content
SpringerLink
Log in

Anti-ribosomal P antibodies and lupus nephritis

  • Review Article
  • Published:
Clinical and Experimental Nephrology Aims and scope Submit manuscript

Abstract

Increasing attention has been paid to the relationship of autoantibodies to ribosomal P proteins (anti-P) with lupus nephritis. Several mechanisms of involvement of anti-P in lupus nephritis have been proposed, including cross-reactivity with anti-dsDNA and anti-endothelial cell antibodies (AECA). In addition, it is also suggested that anti-P might play a role in the development of lupus nephritis through induction of T helper 1 responses. Of note, recent studies have disclosed that the presence of isolated anti-P antibodies may discriminate patients with pure class V lupus nephritis, whereas the simultaneous presence of anti-dsDNA antibodies suggests class V disease with concomitant proliferative lesions. These observations lead to the hypothesis that anti-P and anti-dsDNA might result in membraneous changes and proliferative changes, respectively, although further investigation is required for confirmation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Elkon K, Skelly S, Parnassa A, Moller W, Danho W, Weissbach H, et al. Identification and chemical synthesis of a ribosomal protein antigenic determinant in systemic lupus erythematosus. Proc Natl Acad Sci USA. 1986;83:7419–23.

    Article  CAS  PubMed  Google Scholar 

  2. Bonfa E, Golombek SJ, Kaufman LD, Skelly S, Weissbach H, Brot N, et al. Association between lupus psychosis and anti-ribosomal P protein antibodies. N Engl J Med. 1987;317:265–71.

    Article  CAS  PubMed  Google Scholar 

  3. Schneebaum AB, Singleton JD, West SG, Blodgett JK, Allen LG, Cheronis JC, et al. Association of psychiatric manifestations with antibodies to ribosomal P proteins in systemic lupus erythematosus. Am J Med. 1991;90:54–62.

    Article  CAS  PubMed  Google Scholar 

  4. Elkon KB, Bonfa E, Llovet R, Eisenberg RA. Association between anti-Sm and anti-ribosomal P protein autoantibodies in human systemic lupus erythematosus and MRL/lpr mice. J Immunol. 1989;143:1549–54.

    PubMed  CAS  Google Scholar 

  5. Satoh M, Hamilton KJ, Ajmani AK, Dong X, Wang J, Kanwar YS, et al. Autoantibodies to ribosomal P antigens with immune complex glomerulonephritis in SJL mice treated with pristane. J Immunol. 1996;157:3200–6.

    PubMed  CAS  Google Scholar 

  6. Koffler D, Schur PH, Kunkel HG. Immunological studies concerning the nephritis of systemic lupus erythematosus. J Exp Med. 1967;126:607–24.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Lambert PH, Dixon FJ. Pathogenesis of the glomerulonephritis of NZB/W mice. J Exp Med. 1968;127:507–22.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Livinsky RJ, Cameron JS, Soothill JF. Serum immune complexes and disease activity in lupus nephritis. Lancet. 1977;i:564–7.

    Article  Google Scholar 

  9. Jacob L, Lety MA, Louvard D, Bach JF. Binding of monoclonal anti-DNA autoantibodies to identical protein(s) present at the surface of several human cell types involved in lupus pathogenesis. J Clin Invest. 1985;75:315–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Jacob L, Tron F, Bach JF, Louvard D. A monoclonal anti-DNA antibody also binds to cell-surface protein(s). Proc Natl Acad Sci USA. 1984;81:3843–5.

    Article  CAS  PubMed  Google Scholar 

  11. Raz E, Ben-Bassat H, Davidi T, Shlomai Z, Eilat D. Cross-reactions of anti-DNA autoantibodies with cell surface proteins. Eur J Immunol. 1993;23:383–90.

    Article  CAS  PubMed  Google Scholar 

  12. Sun KH, Liu WT, Tsai CY, Tang SJ, Han SH, Yu CL. Anti-dsDNA antibodies cross-react with ribosomal P proteins expressed on the surface of glomerular mesangial cells to exert a cytostatic effect. Immunology. 1995;85:262–9.

    PubMed  PubMed Central  CAS  Google Scholar 

  13. Sun KH, Liu WT, Tang SJ, Tsai CY, Hsieh SC, Wu TH, et al. The expression of acidic ribosomal phosphoproteins on the surface membrane of different tissues in autoimmune and normal mice which are the target molecules for anti-double-stranded DNA antibodies. Immunology. 1996;87:362–71.

    PubMed  PubMed Central  CAS  Google Scholar 

  14. Martin AL, Reichlin M. Fluctuations of antibody to ribosomal P proteins correlate with appearance and remission of nephritis in SLE. Lupus. 1996;5:22–9.

    Article  CAS  PubMed  Google Scholar 

  15. Chindalore V, Neas B, Reichlin M. The association between anti-ribosomal P antibodies and active nephritis in systemic lupus erythematosus. Clin Immunol Immunopathol. 1998;87:292–6.

    Article  CAS  PubMed  Google Scholar 

  16. Reichlin M, Broyles TF, Hubscher O, James J, Lehman TA, Palermo R, et al. Prevalence of autoantibodies to ribosomal P proteins in juvenile-onset systemic lupus erythematosus compared with the adult disease. Arthritis Rheum. 1999;42:69–75.

    Article  CAS  PubMed  Google Scholar 

  17. Takeda I, Rayno K, Movafagh FB, Wolfson-Reichlin M, Reichlin M. Dual binding capabilities of anti-double-stranded DNA antibodies and anti-ribosomal phosphoprotein (P) antibodies. Lupus. 2001;10:857–65.

    Article  CAS  PubMed  Google Scholar 

  18. Koren E, Reichlin MW, Koscec M, Fugate RD, Reichlin M. Autoantibodies to the ribosomal P proteins react with a plasma membrane-related target on human cells. J Clin Invest. 1992;89:1236–41.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Hirohata S, Nakanishi K. Antiribosomal P protein antibody in human systemic lupus erythematosus reacts specifically with activated T cells. Lupus. 2001;10:612–21.

    Article  CAS  PubMed  Google Scholar 

  20. Nagai T, Arinuma Y, Yanagida T, Yamamoto K, Hirohata S. Anti-ribosomal P protein antibody in human systemic lupus erythematosus up-regulates the expression of proinflammatory cytokines by human peripheral blood monocytes. Arthritis Rheum. 2005;52:847–55.

    Article  CAS  PubMed  Google Scholar 

  21. Romagnani S. The Th1/Th2 paradigm. Immunol Today. 1997;18:263–6.

    Article  CAS  PubMed  Google Scholar 

  22. Mosmann TR, Coffman RL. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol. 1989;7:145–73.

    Article  CAS  PubMed  Google Scholar 

  23. Kamogawa Y, Minasi LA, Carding SR, Bottomly K, Flavell RA. The relationship of IL-4- and IFN gamma-producing T cells studied by lineage ablation of IL-4-producing cells. Cell. 1993;75:985–95.

    Article  CAS  PubMed  Google Scholar 

  24. Wolf SF, Temple PA, Kobayashi M, Young D, Dicig M, Lowe L, et al. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J Immunol. 1991;146:3074–81.

    PubMed  CAS  Google Scholar 

  25. Trinchieri G. Interleukin-12 and its role in the generation of Th1 cells. Immunol Today. 1993;14:335–8.

    Article  CAS  PubMed  Google Scholar 

  26. Manetti R, Parronchi P, Giudizi MG, Piccinni MP, Maggi E, Trinchieri G, et al. Natural killer cell stimulatory factor (interleukin 12 [IL12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J Exp Med. 1993;177:1199–204.

    Article  CAS  PubMed  Google Scholar 

  27. Schmitt E, Hoehn P, Germann T, Rüde E. Differential effects of interleukin-12 on the development of naive mouse CD4+ T cells. Eur J Immunol. 1994;24:343–7.

    Article  CAS  PubMed  Google Scholar 

  28. Nagai T, Yanagida T, Hirohata S. Anti-ribosomal P protein antibody induces Th1 responses by enhancing the production of IL-12 in activated monocytes. Mod Rheumatol. 2011;21:57–62.

    Article  CAS  PubMed  Google Scholar 

  29. Akahoshi M, Nakashima H, Tanaka Y, Kohsaka T, Nagano S, Ohgami E, et al. Th1/Th2 balance of peripheral T helper cells in systemic lupus erythematosus. Arthritis Rheum. 1999;42:1644–8.

    Article  CAS  PubMed  Google Scholar 

  30. Tucci M, Lombardi L, Richards HB, Dammacco F, Silvestris F. Overexpression of interleukin-12 and T helper 1 predominance in lupus nephritis. Clin Exp Immunol. 2008;154:247–54.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Tipping PG, Kitching AR. Glomerulonephritis, Th1 and Th2: what’s new? Clin Exp Immunol. 2005;142:207–15.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. do Nascimento AP, Viana Vdos S, Testagrossa Lde A, Leon EP, Borba EF, Barros RT, et al. Antibodies to ribosomal P proteins: a potential serologic marker for lupus membranous glomerulonephritis. Arthritis Rheum. 2006;54:1568–72.

    Article  CAS  PubMed  Google Scholar 

  33. Frampton G, Moriya S, Pearson JD, Isenberg DA, Ward FJ, Smith TA, et al. Identification of candidate endothelial cell autoantigens in systemic lupus erythematosus using a molecular cloning strategy: a role for ribosomal P protein P0 as an endothelial cell autoantigen. Rheumatology. 2000;39:1114–20.

    Article  CAS  PubMed  Google Scholar 

  34. Yoshio T, Masuyama J, Kano S. Antiribosomal P0 protein antibodies react with the surface of human umbilical vein endothelial cells. J Rheumatol. 1996;23:1311–2.

    PubMed  CAS  Google Scholar 

  35. Reichlin M, Wolfson-Reichlin M. Correlations of anti-dsDNA and anti-ribosomal P autoantibodies with lupus nephritis. Clin Immunol. 2003;108:69–72.

    Article  CAS  PubMed  Google Scholar 

  36. Massardo L, Burgos P, Martínez ME, Pérez R, Calvo M, Barros J, et al. Antiribosomal P protein antibodies in Chilean SLE patients: no association with renal disease. Lupus. 2002;11:379–83.

    Article  CAS  PubMed  Google Scholar 

  37. Chandran V, Upadhyaya SK, Haroon N, Aggarwal A, Misra R. Lack of clinical association with antibodies to ribosomal P proteins in Indian patients with systemic lupus erythematosus. J Rheumatol. 2006;33:1987–9.

    PubMed  CAS  Google Scholar 

  38. Quintana G, Coral-Alvarado P, Aroca G, Patarroyo PM, Chalem P, Iglesias-Gamarra A, et al. Single anti-P ribosomal antibodies are not associated with lupus nephritis in patients suffering from active systemic lupus erythematosus. Autoimmun Rev. 2010;9:750–5.

    Article  CAS  PubMed  Google Scholar 

  39. Reichlin M, Wolfson-Reichlin M. Evidence for the participation of anti-ribosomal P antibodies in lupus nephritis. Arthritis Rheum. 1999;42:2728–9.

    Article  CAS  PubMed  Google Scholar 

  40. Xie C, Liang Z, Chang S, Mohan C. Use of a novel elution regimen reveals the dominance of polyreactive antinuclear autoantibodies in lupus kidneys. Arthritis Rheum. 2003;48:2343–52.

    Article  CAS  PubMed  Google Scholar 

  41. Haddouk S, Marzouk S, Jallouli M, Fourati H, Frigui M, Hmida YB, et al. Clinical and diagnostic value of ribosomal P autoantibodies in systemic lupus erythematosus. Rheumatology. 2009;48:953–7.

    Article  CAS  PubMed  Google Scholar 

  42. Sugisaki K, Takeda I, Kanno T, Nogai S, Abe K, Sakuma H, et al. An anti-nuclear antibody-negative patient with systemic lupus erythematosus (SLE) accompanied with anti-ribosomal P antibody (anti-P). Intern Med. 2002;41:1047–51.

    Article  PubMed  Google Scholar 

  43. Reichlin M. Serological correlations with nephritis in systemic lupus erythematosus. Clin Immunol. 2005;117:12–4.

    Article  CAS  PubMed  Google Scholar 

  44. Bertolaccini ML, Murru V, Khamashta MA. Lack of association of antibodies to ribosomal P proteins with lupus membranous glomerulonephritis: comment on the article by Do Nascimento et al. Arthritis Rheum. 2006;54:4025–6.

    Article  CAS  PubMed  Google Scholar 

  45. do Nascimento AP, Viana Vdos S, Testagrossa Lde A, Leon EP, Borba EF, Barros RT, et al. Author’s reply. Arthritis Rheum. 2006;54:4026–72.

    Article  CAS  Google Scholar 

  46. de Macedo PA, Borba EF, Viana VD, Leon EP, Testagrossa LD, Barros RT, et al. Antibodies to ribosomal P proteins in lupus nephritis: a surrogate marker for a better renal survival? Autoimmun Rev. 2011;10(3):126–30.

    Article  CAS  PubMed  Google Scholar 

Download references

Conflict of interest

The author has declared that no conflict of interest exists.

Author information

Authors and Affiliations

  1. Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, 1-15-1 Kitasato, Minamiku, Sagamihara, Kanagawa, 252-0374, Japan

    Shunsei Hirohata

Authors
  1. Shunsei Hirohata
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Shunsei Hirohata.

About this article

Cite this article

Hirohata, S. Anti-ribosomal P antibodies and lupus nephritis. Clin Exp Nephrol 15, 471–477 (2011). https://doi.org/10.1007/s10157-011-0462-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10157-011-0462-9

Keywords

Search

Navigation