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Association between IGF-1 and chronic kidney disease among US adults

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Clinical and Experimental Nephrology Aims and scope Submit manuscript

Abstract

Background

Insulin-like growth factor (IGF-1) has been associated with cardiovascular disease, hypertension and diabetes in previous studies. However, the association between IGF-1 and chronic kidney disease (CKD) has not been previously studied. Therefore, we examined the association between serum IGF-1 and CKD in a representative sample of US adults.

Methods

We conducted a cross-sectional study of 5388 Third National Health and Nutrition Examination Survey (NHANES III) participants aged ≥20 years of age (55.2% women). Serum IGF-1 was categorized into quartiles for the analysis. CKD (n = 241) was defined as an estimated glomerular filtration rate of <60 mL/min/1.73/m2.

Results and conclusion

Higher serum IGF-1 levels were positively associated with CKD after adjusting for age, sex, race/ethnicity, education levels, smoking, alcohol intake, body mass index, diabetes, hypertension and serum cholesterol. Compared to quartile 1 of IGF-1 (referent), the odds ratio (95% confidence interval) of CKD associated with quartile 4 was 2.66 (1.18–5.99); p trend = 0.008. Subgroup analysis that examined the relation between IGF-1 and CKD by gender showed a consistent positive association. In summary, increasing levels of serum IGF-1 were positively associated with CKD in a representative sample of US adults. Our results suggest that IGF-1 might be a predictor of CKD in Western populations.

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References

  1. Ferns GA, Motani AS, Anggard EE. The insulin-like growth factors: their putative role in atherogenesis. Artery. 1991;18(4):197–225.

    CAS  PubMed  Google Scholar 

  2. Andreassen M, Raymond I, Kistorp C, Hildebrandt P, Faber J, Kristensen LO. IGF1 as predictor of all cause mortality and cardiovascular disease in an elderly population. Eur J Endocrinol. 2009;160(1):25–31.

    Article  CAS  PubMed  Google Scholar 

  3. Juul A, Scheike T, Davidsen M, Gyllenborg J, Jorgensen T. Low serum insulin-like growth factor I is associated with increased risk of ischemic heart disease: a population-based case-control study. Circulation. 2002;106(8):939–44.

    Article  CAS  PubMed  Google Scholar 

  4. Okura Y, Brink M, Zahid AA, Anwar A, Delafontaine P. Decreased expression of insulin-like growth factor-1 and apoptosis of vascular smooth muscle cells in human atherosclerotic plaque. J Mol Cell Cardiol. 2001;33(10):1777–89.

    Article  CAS  PubMed  Google Scholar 

  5. Verdecchia P, Reboldi G, Schillaci G, et al. Circulating insulin and insulin growth factor-1 are independent determinants of left ventricular mass and geometry in essential hypertension. Circulation. 1999;100(17):1802–7.

    CAS  PubMed  Google Scholar 

  6. Ito H, Hiroe M, Hirata Y, et al. Insulin-like growth factor-I induces hypertrophy with enhanced expression of muscle specific genes in cultured rat cardiomyocytes. Circulation. 1993;87(5):1715–21.

    CAS  PubMed  Google Scholar 

  7. Decker RS, Cook MG, Behnke-Barclay M, Decker ML. Some growth factors stimulate cultured adult rabbit ventricular myocyte hypertrophy in the absence of mechanical loading. Circ Res. 1995;77(3):544–55.

    CAS  PubMed  Google Scholar 

  8. Yoshida H, Mitarai T, Kitamura M, et al. The effect of selective growth hormone defect in the progression of glomerulosclerosis. Am J Kidney Dis. 1994;23(2):302–12.

    CAS  PubMed  Google Scholar 

  9. Feld S, Hirschberg R. Growth hormone, the insulin-like growth factor system, and the kidney. Endocr Rev. 1996;17(5):423–80.

    CAS  PubMed  Google Scholar 

  10. Mehls O, Irzynjec T, Ritz E, et al. Effects of rhGH and rhIGF-1 on renal growth and morphology. Kidney Int. 1993;44(6):1251–8.

    Article  CAS  PubMed  Google Scholar 

  11. Frystyk J, Ivarsen P, Skjaerbaek C, Flyvbjerg A, Pedersen EB, Orskov H. Serum-free insulin-like growth factor I correlates with clearance in patients with chronic renal failure. Kidney Int. 1999;56(6):2076–84.

    Article  CAS  PubMed  Google Scholar 

  12. Colao A, Di SC, Cascella T, et al. Relationships between serum IGF1 levels, blood pressure, and glucose tolerance: an observational, exploratory study in 404 subjects. Eur J Endocrinol. 2008;159(4):389–97.

    Article  CAS  PubMed  Google Scholar 

  13. National Center for Health Statistics. Analytic and reporting guidelines: NHANES III. 1996. http://www.cdc.gov/nchs/data/nhanes/nhanes3/nh3gui.pdf. Accessed 23 Nov 2009.

  14. National Center for Health Statistics. Laboratory procedures used for NHANES III. 1996. http://www.cdc.gov/nchs/data/nhanes/nhanes3/cdrom/nchs/manuals/labman.pdf. Accessed 23 Nov 2009.

  15. National Center for Health Statistics. The Third National Health and Nutrition Examination Survey: reference manuals and reports. 1996. http://www.cdc.gov/nchs/data/nhanes/nh3rrm.htm. Accessed 23 Nov 2009.

  16. National Center for Health Statistics. Surplus sera laboratory component: insulin like growth factor. 2006. http://www.cdc.gov/nchs/nhanes/nh3data.htm. Accessed 23 Nov 2009.

  17. Levey AS, Coresh J, Greene T, et al. Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann Intern Med. 2006;145(4):247–54.

    CAS  PubMed  Google Scholar 

  18. Eknoyan G, Levin NW. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 2002;39(2 Suppl 1):S1–266.

    Google Scholar 

  19. Chobanian AV, Bakris GL, Black HR, et al. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003;42(6):1206–52.

    Article  CAS  PubMed  Google Scholar 

  20. Jones JI, Clemmons DR. Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev. 1995;16(1):3–34.

    CAS  PubMed  Google Scholar 

  21. Abdulle AM, Gillett MP, Abouchacra S, et al. Low IGF-1 levels are associated with cardiovascular risk factors in haemodialysis patients. Mol Cell Biochem. 2007;302(1–2):195–201.

    Article  CAS  PubMed  Google Scholar 

  22. Hirschberg R, Kopple JD. Evidence that insulin-like growth factor I increases renal plasma flow and glomerular filtration rate in fasted rats. J Clin Investig. 1989;83(1):326–30.

    Article  CAS  PubMed  Google Scholar 

  23. Feld SM, Hirschberg R, Artishevsky A, Nast C, Adler SG. Insulin-like growth factor I induces mesangial proliferation and increases mRNA and secretion of collagen. Kidney Int. 1995;48(1):45–51.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

This study was funded by an American Heart Association National Clinical Research program grant (AS).

Conflict of interest statement

There are no conflicts of interest related to this manuscript.

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Authors and Affiliations

  1. Department of Community Medicine, West Virginia University School of Medicine, P.O. Box 9190, Morgantown, WV, 26506-9190, USA

    Srinivas Teppala, Anoop Shankar & Charumathi Sabanayagam

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  1. Srinivas Teppala
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  2. Anoop Shankar
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  3. Charumathi Sabanayagam
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Correspondence to Anoop Shankar.

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Teppala, S., Shankar, A. & Sabanayagam, C. Association between IGF-1 and chronic kidney disease among US adults. Clin Exp Nephrol 14, 440–444 (2010). https://doi.org/10.1007/s10157-010-0307-y

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  • DOI: https://doi.org/10.1007/s10157-010-0307-y

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