Abstract
A 6-year-old boy received renal transplantation and was treated with methylprednisolone, cyclosporine A and mizoribine. He developed Epstein–Barr virus-associated malignant lymphoma at 10 years and thyroid papillary carcinoma at 20 years of age. Chemotherapy for the malignant lymphoma was done after withdrawal of cyclosporine A and mizoribine, and thyroidectomy was performed for thyroid carcinoma. He was well and his serum creatinine was 1.0 mg/dl at 22 years of age. To our knowledge, no pediatric renal transplant recipient who had thyroid carcinoma or two different types of tumor has been reported in Japan.
Similar content being viewed by others
References
Penn I. Malignancy in children. In: Tejani AH, Fine RN, editors. Pediatric renal transplantation. New York: Wiley; 1994. p. 461–70.
Sugitani A. Malignant tumor after renal transplantation (in Japanese). Jpn J Nephrol. 2005;47:430–6.
Wingen AM, Wiesel M, Möhring K, Schärer K, Mehls O. Malignancies in children with renal replacement therapy. Transplant Proc. 1994;26:5–6.
Dror Y, Greenberg M, Taylor G, Superina R, Hebert D, West L, et al. Lymphoproliferative disorders after organ transplantation in children. Transplantation. 1999;67:990–8.
Motoyama O, Hasegawa A, Aikawa A, Arai K, Ohara T. Clinical management and outcome of preemptive renal transplantation in children and adolescents. Clin Exp Nephrol. 2002;6:237–41.
Shroff R, Rees L. The post-transplant lymphoproliferative disorder, a literature review. Pediatr Nephrol. 2004;19:369–77.
Burmeister LA, Sandberg M, Carty SE, Watson CG. Thyroid carcinoma found at parathyroidectomy. Association with primary, secondary, and tertiary hyperparathyroidism. Cancer. 1997;79:1611–6.
Herzog CE. Rare tumors. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, editors. Nelson textbook of pediatrics. 18th ed. Philadelphia: Saunders; 2007. p. 2157–9.
Mike V, Meadows AT, D’Angio GJ. Incidence of second malignant neoplasms in children: results of an international study. Lancet. 1982;2:1326–31.
Olsen JH, Garwicz S, Hertz H, Jonmundsson G, Langmark F, Lanning M, et al. Second malignant neoplasms after cancer in childhood or adolescence. Br Med J. 1993;307:1030–6.
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Motoyama, O., Takasu, J., Kawamura, T. et al. A male patient with malignant lymphoma and thyroid papillary carcinoma after pediatric renal transplantation. Clin Exp Nephrol 14, 94–96 (2010). https://doi.org/10.1007/s10157-009-0210-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10157-009-0210-6