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Secondary membranous glomerulonephritis associated with recipient residual lymphoma cells after allogeneic bone marrow transplantation

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Abstract

A 29-year-old man with malignant lymphoma developed membranous nephropathy (MN) after allogeneic bone-marrow transplantation (BMT). There had been no obvious findings of graft versus host diseases (GVHD) after BMT, and the dosage of immunosuppressant drugs had not been reduced during this period. At the onset of MN, a few lymphoma cells still remained in the bone marrow; the patient achieved complete remission of MN after the disappearance of the lymphoma cells. In this case it is suggested that immune complexes including antigens expressed by lymphoma cells might induce MN. Therefore, this is a significant case that may reveal an alternative mechanism of the onset of MN related to BMT.

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References

  1. Imai H, Oyama Y, Miura AB, Endoh M, Sakai H. Hematopoietic cell transplantation-related nephropathy in Japan. Am J Kidney Dis. 2000;36:474–80.

    Article  CAS  PubMed  Google Scholar 

  2. Stevenson WS, Nankivell BJ, Hertzberg MS. Nephrotic syndrome after stem cell transplantation. Clin Transplant. 2005;19:141–4.

    Article  PubMed  Google Scholar 

  3. Otani M, Shimojo H, Shiozawa S, Shigematsu H. Renal involvement in bone marrow transplantation. Nephrology. 2005;10:530–6.

    Article  PubMed  Google Scholar 

  4. Keur I, Krediet RT, Arisz L. Glomerulopathy as a paraneoplastic phenomenon. Neth J Med. 1989;34:270–84.

    CAS  PubMed  Google Scholar 

  5. Lewis MG, Loughridge LW, Phillips TM. Immunological studies in nephrotic syndrome associated with extrarenal malignant disease. Lancet. 1971;2:134–5.

    Article  CAS  PubMed  Google Scholar 

  6. Sutherland JC, Mardiney MR Jr. Immune complex disease in the kidneys of lymphoma-leukemia patients: the presence of an Oncornavirus-related antigen. J Natl Cancer Inst. 1973;50:633–44.

    Article  CAS  PubMed  Google Scholar 

  7. Koyama A, Inage H, Kobayashi M, Narita M, Tojo S. Effect of chemical cationization of antigen on glomerular localization of immune complexes in active models of serum sickness nephritis in rabbits. Immunology. 1986;58:529–34.

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Koyama A, Inage H, Kobayashi M, Ohta Y, Narita M, Tojo S, et al. Role of antigenic charge and antibody avidity on the glomerular immune complex localization in serum sickness of mice. Clin Exp Immunol. 1986;64:606–14.

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Ohtani H, Wakui H, Komatsuda A, Okuyama S, Masai R, Maki N, et al. Distribution of glomerular IgG subclass deposits in malignancy-associated membranous nephropathy. Nephrol Dial Transplant. 2004;19:574–9.

    Article  CAS  PubMed  Google Scholar 

  10. Hiesse C, Goldschmidt E, Santelli G, Charpentier B, Machover D, Fries D. Membranous nephropathy in a bone marrow transplant recipient. Am J Kidney Dis. 1988;11:188–91.

    Article  CAS  PubMed  Google Scholar 

  11. Müller GA, Müller CA, Markovic-Lipkowski J, Bross-Bach U, Schmidt H, Ehninger G, et al. Membranous nephropathy after bone marrow transplantation in ciclosporin treatment. Nephron. 1989;51:555–6.

    Article  PubMed  Google Scholar 

  12. Barbara JAJ, Thomas AC, Smith PS, Gillis D, Ho JOK, Woodroffe AJ. Membranous nephropathy with graft-versus-host disease in a bone marrow transplant recipient. Clin Nephrol. 1992;37:115–8.

    CAS  PubMed  Google Scholar 

  13. Sato N, Kishi K, Yagisawa K, Kasama J, Karasawa R, Shimada H, et al. Nephrotic syndrome in a bone marrow transplant recipient with chronic graft-versus-host disease. Bone Marrow Transplant. 1995;16:303–5.

    CAS  PubMed  Google Scholar 

  14. Yorioka N, Taniguchi Y, Shimote K, Komo T, Yamakido M, Hyodo H, et al. Membranous nephropathy with chronic graft-versus-host disease in a bone marrow transplant recipient. Nephron. 1998;80:371–2.

    Article  CAS  PubMed  Google Scholar 

  15. Nergizoglu G, Keven K, Ates K, Üstün C, Tulunay Ö, Beksac M, et al. Chronic graft-versus-host disease complicated by membranous glomerulonephritis. Nephrol Dial Transplant. 1999;14:2461–3.

    Article  CAS  PubMed  Google Scholar 

  16. Oliveira JSR, Bahia D, Franco M, Balda C, Stella S, Kerbauy J. Nephrotic syndrome as a clinical manifestation of graft-versus-host disease (GVHD) in a marrow transplant recipient after cyclosporine withdrawal. Bone Marrow Transplant. 1999;23:99–101.

    Article  CAS  PubMed  Google Scholar 

  17. Lin J, Markowitz GS, Nicolaides M, Hesdorffer CS, Appel GB, D’Agati VD, et al. Membranous glomerulopathy associated with graft-versus-host disease following allogeneic stem cell transplantation: report of 2 cases and review of the literature. Am J Nephrol. 2001;21:351–6.

    Article  CAS  PubMed  Google Scholar 

  18. Rossi L, Cardarelli F, Vampa ML, Buzio C, Olivetti G. Membranous glomerulonephritis after haematopoietic cell transplantation for multiple myeloma. Nephron. 2001;88:260–3.

    Article  CAS  PubMed  Google Scholar 

  19. Yabana M, Takagi N, Kihara M, Muto R, Tamura K, Maemoto S, et al. A case of nephrotic syndrome after bone marrow transplantation. Nippon Jinzo Gakkai Shi. 1997;39:414–20.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Pathophysiology of Renal Diseases, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan

    Kentaro Sakai, Joichi Usui, Hirayasu Kai, Masahiro Hagiwara, Naoki Morito, Chie Saito, Keigyou Yoh, Syuichi Tsuruoka & Kunihiro Yamagata

  2. Department of Nephrology, Tokyo Medical University Kasumigaura Hospital, Ami, Ibaraki, Japan

    Kouichi Hirayama

  3. Department of Pathology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan

    Kumi Aita & Michio Nagata

Authors
  1. Kentaro Sakai
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  2. Joichi Usui
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  3. Hirayasu Kai
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  4. Masahiro Hagiwara
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  5. Naoki Morito
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  6. Chie Saito
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  7. Keigyou Yoh
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  8. Syuichi Tsuruoka
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  9. Kouichi Hirayama
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  10. Kumi Aita
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  11. Michio Nagata
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  12. Kunihiro Yamagata
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Corresponding author

Correspondence to Kunihiro Yamagata.

Additional information

A presentation of this case was given a prize at the 37th Eastern Regional Meeting of the Japanese Society of Nephrology, October 2007, Saitama, Japan.

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Sakai, K., Usui, J., Kai, H. et al. Secondary membranous glomerulonephritis associated with recipient residual lymphoma cells after allogeneic bone marrow transplantation. Clin Exp Nephrol 13, 174–178 (2009). https://doi.org/10.1007/s10157-008-0120-z

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  • DOI: https://doi.org/10.1007/s10157-008-0120-z

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