Abstract
A 65-year-old woman with a 48-year history of Behçet’s disease associated with nephrotic syndrome is described. Immunofluorescence study revealed IgA nephropathy. Following treatment with an angiotensin II type-I receptor-blocker, an anti-platelet drug, and an HMG-CoA reductase inhibitor, accompanied by dietary restrictions of protein and sodium, proteinuria was markedly decreased. This report describes our experience with a rare entity of Behçet’s disease complicated by nephrotic syndrome due to IgA nephropathy. Routine urine examination and renal biopsy are needed for the detection and diagnosis of renal problems with Behçet’s disease.
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Yazici H, Fresko I, Yurdakul S. Behçet’s syndrome: disease manifestations, management, and advances in treatment. Nat Clin Pract Rheumatol. 2007;3:148–55.
Takeno M, Sakane T. Vascular involvement in Behçet’s disease. Intern Med. 2001;40:3–4.
Akpolat T, Akkoyunlu M, Akpolat I, Dilek M, Odabas AR, Ozen S. Renal Behçet’s disease: a cumulative analysis. Semin Arthritis Rheum. 2002;31:317–37.
Behçet H. Uber rezidivierende aphthose, durch ein virus verursachte Geschwure am Auge und an den Genitalien. Dermatol Wochenschr. 1937;105:1152–7.
Lakhanpal S, Tani K, Lie JT, Katoh K, Ishigatsubo Y, Ohkubo T. Pathologic features of Behçet’s syndrome: a review of Japanese autopsy registry data. Hum Pathol. 1985;16:790–5.
Herreman G, Beaufils H, Godeau P, Cassou B, Wechsler B, Boujeau J, Chomette G. Behçet’s syndrome and renal involvement: a histological and immunofluorescent study of 11 renal biopsies. Am J Med Sci. 1982;284:10–7.
Maeshima E, Nakamura Y, Otani H, Yamada Y, Mune M, Yukawa S. Behçet’s disease complicated by IgA nephropathy and interstitial nephritis. Clin Exp Nephrol. 2000;4:257–60.
Hirano M, Yamagishi T, Sato M, Fueki H, Arakawa M. A case of Behçet’s syndrome with immune complex nephritis. Naika. 1978;42:511–3.
Wilkey D, Yocum DE, Oberley TD, Sundstrom WR, Karl L. Budd-Chiari syndrome and renal failure in Behçet disease. Report of a case and review of the literature. Am J Med. 1983;75:541–50.
Miura M, Tomino Y, Suga T, Endoh M, Nomoto Y, Sakai H, Furuya K, Kobayashi Y. A case of Behçet’s disease associate with membranous nephropathy. Tokai J Exp Clin Med. 1984;9:231–5.
Donnelly S, Jothy S, Barre P. Crescentic glomerulonephritis in Behçet’s syndrome—results of therapy and review of the literature. Clin Nephrol. 1989;31:213–8.
Malik GH, Sirwal IA, Pandit KA. Behçet’s syndrome associated with minimal change glomerulonephritis and renal vein thrombosis. Nephron. 1989;52:87–9.
Akiyama Y, Suzuki T, Tanaka M, Ohno S, Imai F, Kobayashi K, Matsuo H, Shibata T. A case of Behçet’s disease associated with aortic regurgitation and nephrotic syndrome. Ryumachi. 1995;35:910–4.
Komada H, Takeda Y, Fukagawa M. Extensive deep vein thrombosis in a postpartum woman with Behçet’s disease associated with nephrotic syndrome. Kidney Int. 2007;71:6.
Fernandes PF, Junior GB, Barros FA, Sousa DC, Franco LM, Patrocinio RM. Behcet’s disease and IgA nephropathy: report of this association in a patient from Brazil and literature review. Invest Clin. 2006;47:405–11.
Yver L, Blanchier D, Aouragh F, Turpin Y, Chaubert N, Laregue M, Goujon JM, Touchard G. Renal involvement in Behcet’s disease. Case report and review of the literature. Nephron. 1996;73:689–91.
Hemmen T, Perez-Canto A, Distler A, Offermann G, Braun J. IgA nephropathy in a patient with Behcet’s syndrome—case report and review of literature. Br J Rheumatol. 1997;36:696–9.
Chan JC, Trachtman H. Modulating the progression in IgA nephropathy. Nephron Clin Pract. 2006;104:c61–8.
Taji Y, Kuwahara T, Shikata S, Morimoto T. Meta-analysis of antiplatelet therapy for IgA nephropathy. Clin Exp Nephrol. 2006;10:268–73.
Tomino Y, Sakai H; Special Study Group (IgA Nephropathy) on Progressive Glomerular Disease. Clinical guidelines for immunoglobulin A (IgA) nephropathy in Japan, second version. Clin Exp Nephrol. 2003;7:93–7.
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Hashimoto, T., Toya, Y., Kihara, M. et al. Behçet’s disease complicated by IgA nephropathy with nephrotic syndrome. Clin Exp Nephrol 12, 224–227 (2008). https://doi.org/10.1007/s10157-008-0029-6
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DOI: https://doi.org/10.1007/s10157-008-0029-6