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Endothelial progenitor cells for postnatal vasculogenesis

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Abstract

Bone marrow-derived endothelial progenitor cells (EPCs) are present in the systemic circulation, are augmented in response to certain cytokines and/or tissue ischemia, and are home to – as well as incorporate into – sites of neovascularization. On the basis of these aspects, EPCs have attractive potential therapeutic applications for cardiovascular ischemic diseases as a novel cell-based strategy, mainly via a vasculogenesis mechanism. This review provides an update of the biology of EPCs, as well as highlighting the potential use of these cells for therapeutic regeneration.

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Authors and Affiliations

  1. Department of Regenerative Medicine Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, 259-1193, Japan

    Masamichi Eguchi, Haruchika Masuda & Takayuki Asahara

  2. Stem Cell Translational Research, Institute of Biomedical Research and Innovation/RIKEN Center for Developmental Biology, Kobe, Japan

    Takayuki Asahara

Authors
  1. Masamichi Eguchi
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  2. Haruchika Masuda
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  3. Takayuki Asahara
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Correspondence to Takayuki Asahara.

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Eguchi, M., Masuda, H. & Asahara, T. Endothelial progenitor cells for postnatal vasculogenesis. Clin Exp Nephrol 11, 18–25 (2007). https://doi.org/10.1007/s10157-006-0448-1

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  • DOI: https://doi.org/10.1007/s10157-006-0448-1

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