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Prevalence of fecal carriage of extended-spectrum β-lactamase-producing Enterobacteriaceae among healthy adult people in Japan

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Journal of Infection and Chemotherapy

Abstract

In Japan, the prevalence of extended-spectrum β-lactamase (ESBL) producers in hospital settings has shown an increasing trend. In the present study, we investigated the prevalence of the fecal carriage of ESBL-producing Enterobacteriaceae among healthy adults. Stool samples were collected for the phenotypic and genotypic identification of ESBL-producing Enterobacteriaceae. We found the prevalence of ESBL producers to be 6.4% by phenotypic identification, and 92.9% of them possessed the bla CTX-M gene. Among the CTX-M ESBL-producing Enterobacteriaceae, we identified 11 Escherichia coli and 2 Klebsiella pneumonia strains. The findings suggest that the fecal carriage of CTX-M-type ESBL producers by healthy people is rapidly increasing in Japan. This may be one of the causes of the increased spread of ESBL-producing bacteria in hospitals.

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Acknowledgments

This work was supported by KAKENHI (Grant-in-Aid for Exploratory Research), the Ministry of Education, Culture, Sports, Science and Technology, Japan.

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There is no conflict to declare.

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Authors and Affiliations

  1. Department of Bioinformatics, Osaka University Graduate School of Medicine, 1-7 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Ulzii-Orshikh Luvsansharav, Itaru Hirai, Marie Niki, Arisa Nakata, Aya Yoshinaga & Yoshimasa Yamamoto

  2. Health Care Center, Osaka University, Osaka, 560-0043, Japan

    Toshiki Moriyama

Authors
  1. Ulzii-Orshikh Luvsansharav
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  2. Itaru Hirai
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  3. Marie Niki
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  4. Arisa Nakata
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  5. Aya Yoshinaga
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  6. Toshiki Moriyama
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  7. Yoshimasa Yamamoto
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Corresponding author

Correspondence to Yoshimasa Yamamoto.

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Luvsansharav, UO., Hirai, I., Niki, M. et al. Prevalence of fecal carriage of extended-spectrum β-lactamase-producing Enterobacteriaceae among healthy adult people in Japan. J Infect Chemother 17, 722–725 (2011). https://doi.org/10.1007/s10156-011-0225-2

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  • DOI: https://doi.org/10.1007/s10156-011-0225-2

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