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Characteristics and disease severity of healthcare-associated pneumonia among patients in a hospital in Kitakyushu, Japan

  • Original Article
  • Published:
Journal of Infection and Chemotherapy

Abstract

Healthcare-associated pneumonia (HCAP) is a newly identified condition, and epidemiologic studies in Japan are still limited. We retrospectively observed patients with HCAP and community-acquired pneumonia (CAP) who were hospitalized between December 2004 and March 2005, and compared their disease characteristics. A total of 34 patients (14 with HCAP and 20 with CAP) were evaluated. Of the patients with HCAP, seven (50%) were hospitalized for at least 2 days in the preceding 90 days and five (35.7%) resided in a nursing home or extended care facility. Compared with patients with CAP, patients with HCAP were older, had more complications, including central nerve diseases, had greater disease severity, but lower serum albumin level. More methicillin-resistant Staphylococcus aureus, Pseudomonas spp., and anaerobes were isolated from patients with HCAP than from those with CAP. Conversely, more Streptococcus pneumoniae was detected and more penicillin was used in patients with CAP. This study provides additional evidence that HCAP should be distinguished from CAP and suggests the pathogenesis and therapeutic strategy for HCAP may be similar to those for hospital-acquired pneumonia.

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Abbreviations

A-DROP:

Age, dehydration, respiratory failure, orientation disturbance, low blood pressure

ATS:

American Thoracic Society

CAP:

Community-acquired pneumonia

CI:

Confidence interval

ESBL:

Extended-spectrum β-lactamase

HAP:

Hospital-acquired pneumonia

HCAP:

Healthcare-associated pneumonia

IDSA:

Infectious Diseases Society of America

I-ROAD:

Immunodeficiency, age, respiratory failure, orientation disturbance, dehydration

MDR:

Multidrug-resistant

MRSA:

Methicillin-resistant Staphylococcus aureus

NHAP:

Nursing home-acquired pneumonia

PDR:

Potentially drug-resistant

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Acknowledgments

The authors would like to thank Yoshimasa Wagatsuma (Sunmedia, Tokyo, Japan) and Forte Co. Ltd (Tokyo, Japan) for their kind support regarding statistical analysis and language correction, respectively.

Conflict of interest

The authors have no conflicts of interest in relation to this article.

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Authors and Affiliations

  1. Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

    Masafumi Seki, Kohji Hashiguchi, Akitaka Tanaka, Kosuke Kosai, Tomoyuki Kakugawa, Koichi Izumikawa, Hiroshi Kakeya, Yoshihiro Yamamoto & Shigeru Kohno

  2. Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan

    Masafumi Seki, Kohji Hashiguchi, Akitaka Tanaka, Kosuke Kosai, Tomoyuki Kakugawa, Shintaro Kurihara, Koichi Izumikawa, Hiroshi Kakeya, Yoshihiro Yamamoto, Katsunori Yanagihara, Takayoshi Tashiro & Shigeru Kohno

  3. Kitakyushu City Yahata Hospital, Kitakyushu, Fukuoka, Japan

    Masafumi Seki, Kohji Hashiguchi, Akitaka Tanaka, Kosuke Kosai, Tomoyuki Kakugawa & Yukikazu Awaya

  4. Nagasaki Atomic Bomb Hospital, Nagasaki, Japan

    Kohji Hashiguchi

Authors
  1. Masafumi Seki
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  2. Kohji Hashiguchi
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  3. Akitaka Tanaka
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  4. Kosuke Kosai
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  5. Tomoyuki Kakugawa
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  6. Yukikazu Awaya
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  7. Shintaro Kurihara
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  8. Koichi Izumikawa
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  9. Hiroshi Kakeya
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  10. Yoshihiro Yamamoto
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  11. Katsunori Yanagihara
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  12. Takayoshi Tashiro
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  13. Shigeru Kohno
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Corresponding author

Correspondence to Masafumi Seki.

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Seki, M., Hashiguchi, K., Tanaka, A. et al. Characteristics and disease severity of healthcare-associated pneumonia among patients in a hospital in Kitakyushu, Japan. J Infect Chemother 17, 363–369 (2011). https://doi.org/10.1007/s10156-010-0127-8

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  • DOI: https://doi.org/10.1007/s10156-010-0127-8

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