Abstract
The purpose of this study was to elucidate the risk factors for surgical-site infection (SSI) in oral cancer surgery with microvascular free-flap reconstructions and to propose appropriate SSI prevention. There were 276 patients who underwent oral cancer surgery with microvascular free-flap reconstructions at the Department of Oral and Maxillo-facial Surgery of Tokai University Hospital. The following variables were assessed as risk factors for SSIs: preoperative variables, including age, sex, body mass index, American Society of Anesthesiologist’s (ASA) score, debilitating comorbidities, smoking, alcohol consumption, and Union Internationale Contre le Cancer Tumor Node Metastasis (UICC-TNM) classification; and operative variables, including duration of surgery, amount of blood loss, quantity of blood transfusion, tracheostomy, area of neck dissection, and previous chemotherapy. Statistical analysis was conducted to determine whether these factors constitute risks for SSI. Total overall SSI rate was 40.6% (112/276). When the occurrence of SSI was compared with the variables, ASA score (P = 0.036), T stage (P = 0.013), duration of surgery (P < 0.001), blood loss (P = 0.001), blood transfusion (P = 0.01), and area of neck dissection (P = 0.009) showed statistical significance. Analysis of these variables with a logistic regression model yielded ASA score and duration of surgery as significant factors. There was a tendency for blood loss and duration of surgery to increase in patients with a high T stage. A high T stage not only broadens the resection area and increases surgical invasiveness, it also increases susceptibility to dead space after microvascular reconstruction for oral cancer. Particular care in treating the wound should be taken in surgical patients with high T-stage scores. The occurrence of SSI is of particular concern in oral cancer surgery in patients with high ASA scores.
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References
Mangram AJ, Horan TC, Pearson ML, Silver LC, Jarvis WR. Guideline for prevention of surgical site infection, 1999. Hospital Infection Control Practices Advisory Committee. Infect Control Hosp Epidemiol. 1999;20:250–78.
Lilani SP, Jangale N, Chowdhary A, Daver GB. Surgical site infection in clean and clean-contaminated cases. Indian J Med Microbiol. 2005;23:249–52.
Chattopadhyay R, Zaroukian S, Potvin E. Surgical site infection rates at the Pontiac Health Care Centre, a rural community hospital. Can J Rural Med. 2006;11:41–8.
Uchino M, Ikeuchi H, Tsuchida T, Nakajima K, Tomita N, Takesue Y. Surgical site infection following surgery for inflammatory bowel disease in patients with clean-contaminated wounds. World J Surg. 2009;33:1042–8.
Penel N, Fournier C, Lefebvre D, Lefebvre JL. Multivariate analysis of risk factors for wound infection in head and neck squamous cell carcinoma surgery with opening of mucosa. Study of 260 surgical procedures. Oral Oncol. 2005;41:294–303.
Lotfi CJ, Cavalcanti Rde C, Costa e Silva AM, Latorre Mdo R, Ribeiro Kde C, Carvalho AL, et al. Risk factors for surgical-site infections in head and neck cancer surgery. Otolaryngol Head Neck Surg. 2008;138:74–80.
Penel N, Mallet Y, Roussel-Delvallez M, Lefebvre JL, Yazdanpanah Y. Factors determining length of the postoperative hospital stay after major head and neck cancer surgery. Oral Oncol. 2008;44:555–62.
Liu SA, Wong YK, Poon CK, Wang CC, Wang CP, Tung KC. Risk factors for wound infection after surgery in primary oral cavity cancer patients. Laryngoscope. 2007;117:166–71.
Ogihara H, Takeuchi K, Majima Y. Risk factors of postoperative infection in head and neck surgery. Auris Nasus Larynx. 2009;36:457–60.
Weber RS, Raad I, Frankenthaler R, Hankins P, Byers RM, Guillamondegui O, et al. Ampicillin-sulbactam vs clindamycin in head and neck oncologic surgery. The need for gram-negative coverage. Arch Otolaryngol Head Neck Surg. 1992;118:1159–63.
Johnson JT, Kachman K, Wagner RL, Myers EN. Comparison of ampicillin/sulbactam versus clindamycin in the prevention of infection in patients undergoing head and neck surgery. Head Neck. 1997;19:367–71.
Batstone MD, Lowe D, Shaw RJ, Brown JS, Vaughan ED, Rogers SN. Passive versus active drainage following neck dissection: a non-randomised prospective study. Eur Arch Otorhinolaryngol. 2009;266:121–4.
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Karakida, K., Aoki, T., Ota, Y. et al. Analysis of risk factors for surgical-site infections in 276 oral cancer surgeries with microvascular free-flap reconstructions at a single university hospital. J Infect Chemother 16, 334–339 (2010). https://doi.org/10.1007/s10156-010-0108-y
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DOI: https://doi.org/10.1007/s10156-010-0108-y