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Increase of atypical lymphocytes expressing CD4+/CD45RO+ in an infectious mononucleosis-like syndrome associated with hepatitis A virus infection

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Journal of Infection and Chemotherapy

Abstract

Subpopulations of regular and atypical lymphocytes in the peripheral blood of a 24-year-old man with an infectious mononucleosis (IM)-like syndrome associated with hepatitis A virus (HAV) infection were analyzed. The ratio of CD4+ to CD8+ cells was in the normal range (1.19 and 1.23 in the regular and atypical lymphocytes, respectively), with no increase in CD8+ cells. The percentage of CD8+/CD11b- cells was not increased in the atypical lymphocytes. However, CD45RO+ was expressed on 86.3% of CD4+ atypical lymphocytes. The present data suggest that atypical lymphocytes expressing CD4+/CD45RO+ may play the role of helper T cells in the immune system in the development of IM-like syndrome associated with HAV infection.

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Authors and Affiliations

  1. Division of Respiratory Medicine, Machida Municipal Hospital, 2-15-41 Asahi-cho, Machida, Tokyo, 194-0023, Japan

    Hidehiro Watanabe, Hideaki Sekine, Tomonori Uruma, Sai Nagasaki, Tokuroh Tsunoda, Yutaka Machida, Kentaro Kobayashi & Hisashi Igarashi

Authors
  1. Hidehiro Watanabe
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  2. Hideaki Sekine
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  3. Tomonori Uruma
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  4. Sai Nagasaki
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  5. Tokuroh Tsunoda
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  6. Yutaka Machida
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  7. Kentaro Kobayashi
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  8. Hisashi Igarashi
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Correspondence to Hidehiro Watanabe.

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Watanabe, H., Sekine, H., Uruma, T. et al. Increase of atypical lymphocytes expressing CD4+/CD45RO+ in an infectious mononucleosis-like syndrome associated with hepatitis A virus infection. J Infect Chemother 15, 187–190 (2009). https://doi.org/10.1007/s10156-009-0677-9

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  • DOI: https://doi.org/10.1007/s10156-009-0677-9

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