Abstract
The importance of oseltamivir as a strategy for the treatment of influenza has been recognized; however, the risk of acute hemorrhagic colitis should be considered, although it is rare. This report describes a case of acute hemorrhagic colitis in a 61-year-old Japanese man after the oral administration of oseltamivir for influenza A. A definitive diagnosis of influenza A was made using a rapid diagnosis kit. Abdominal pain, diarrhea, and hematochezia occurred the day after the first administration of oseltamivir (The patient had taken two capsules of oseltamivir). Endoscopic examination revealed extensive acute hemorrhagic colitis. Histopathological examination of the colonic mucosa revealed small atrophic glands with partial deciduation of the epithelium and a decrease in the number of goblet cells. Hemorrhage and mild infiltration of inflammatory cells were observed as well. These changes were suggestive of an ischemic change. A culture test showed normal flora.
Similar content being viewed by others
References
JJ Treanor (2006) ArticleTitleAvian influenza: exploring all the avenues Ann Intern Med 145 631–2 Occurrence Handle16940335
M Ozawa Y Kawaoka (2006) ArticleTitleInfluenza pandemic – current crisis J J A Inf D 80 1–7
Y Sakai S Fujinuma (2004) ArticleTitleDrug-induced colitis Rinsyo to Kenkyu 81 1460–3
R Benoit D Dolval J Loulergue Y Bacq JM Oliver A Audurier EH Metman (1992) ArticleTitlePost-antibiotic diarrheas: role of Klebsiella oxytoca Gastroenterol Clin Biol 16 860–4 Occurrence Handle1483555 Occurrence Handle1:STN:280:ByyC3s7gvFE%3D
T Tomiyasu O Tsuruta K Mitsuyama H Kono K Karahara K Yoshimori et al. (2005) ArticleTitleDrug-induced hemorrhagic enterocolitis Stomach and Intestine (Tokyo) 40 611–5
Y Yoneda Y Kobayashi T Nunoi K Takeda A Matsumori M Andoh et al. (2006) ArticleTitleAcute hemorrhagic colitis induced by the neuraminidase inhibitor oseltamivir J Japanese Soc Gastroenterol 103 1270–3
MS Cappell (2004) ArticleTitleColonic toxicity of administered drugs and chemicals Am J Gastroenterol 99 1175–90 Occurrence Handle15180742 Occurrence Handle10.1111/j.1572-0241.2004.30192.x Occurrence Handle1:CAS:528:DC%2BD2cXmt1Chu7g%3D
H Moulis RJ Vender (1994) ArticleTitleAntibiotic-associated hemorrhagic colitis J Clin Gastroenterol 18 227–31 Occurrence Handle8034921 Occurrence Handle10.1097/00004836-199404000-00012 Occurrence Handle1:STN:280:ByuA3cfkvVU%3D
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Matsushita, M., Nishihara, H., Nishiyama, R. et al. Acute hemorrhagic colitis associated with oral administration of oseltamivir for the treatment of influenza A. J Infect Chemother 13, 267–269 (2007). https://doi.org/10.1007/s10156-007-0527-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10156-007-0527-6