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Molecular epidemiology of uropathogenic Escherichia coli

  • REVIEW ARTICLE
  • Published:
Journal of Infection and Chemotherapy

Abstract

Escherichia coli is the most common cause of complicated as well as uncomplicated urinary tract infections (UTIs). Most of these uropathogenic E. coli (UPEC) strains exhibit certain virulence factors (VFs), including adhesins, iron uptake systems, synthesis of cytotoxins, and specific O:K:H serotypes. Molecular epidemiological studies of UPEC have contributed to the discovery of uropathogenic VFs, to an understanding of the pathogenesis of UTIs as ascending infections, and to the clarification of genetic linkages between different virulence genes such as pathogenicity islands (PAIs), which are one of the mechanisms for horizontal VF gene transfers between the same or related species. Uropathogenic VFs not only play an important role individually but also work cooperatively in a fine-tuned manner with coordinated regulation and expression.

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References

  1. JR Johnson (1991) ArticleTitleVirulence factors in Escherichia coli urinary tract infection Clin Microbiol Rev 4 80–128 Occurrence Handle1672263 Occurrence Handle1:STN:280:By6C28fhtlU%3D

    PubMed  CAS  Google Scholar 

  2. S Yamamoto A Terai K Yuri H Kurazono Y Takeda O Yoshida (1995) ArticleTitleDetection of urovirulence factors in Eschericiha coli by multiplex polymerase chain reaction FEMS Immunol Med Microbiol 12 85–90 Occurrence Handle8589667 Occurrence Handle10.1111/j.1574-695X.1995.tb00179.x Occurrence Handle1:CAS:528:DyaK2MXptlCmurY%3D

    Article  PubMed  CAS  Google Scholar 

  3. A Terai S Yamamoto K Mitsumori Y Okada H Kurazono Y Takeda O Yoshida (1997) ArticleTitle Escherichia coli virulence factors and serotypes in acute bacterial prostatitis Int J Urol 4 289–94 Occurrence Handle9255669 Occurrence Handle10.1007/BF02258352 Occurrence Handle1:STN:280:ByiA1MblsFU%3D

    Article  PubMed  CAS  Google Scholar 

  4. S Yamamoto K Nakata K Yuri H Katae A Terai H Kurazono et al. (1996) ArticleTitleAssessment of the significance of virulence factors of uropathogenic Escherichia coli in experimental urinary tract infection in mice Microbiol Immunol 40 607–10 Occurrence Handle8908603 Occurrence Handle1:CAS:528:DyaK28XmtlWhtL8%3D

    PubMed  CAS  Google Scholar 

  5. J Hacker JB Kaper (2000) ArticleTitlePathogenicity islands and the evolution of microbes Annu Rev Microbiol 54 641–79 Occurrence Handle11018140 Occurrence Handle10.1146/annurev.micro.54.1.641 Occurrence Handle1:CAS:528:DC%2BD3cXotFWrsLg%3D

    Article  PubMed  CAS  Google Scholar 

  6. TA Oelschlaeger U Dobrindt J Hacker (2002) ArticleTitleVirulence factors of uropathogens Curr Opin Urol 12 33–8 Occurrence Handle11753131 Occurrence Handle10.1097/00042307-200201000-00007

    Article  PubMed  Google Scholar 

  7. S Kanamaru H Kurazono S Ishitoya A Terai T Habuchi M Nakano et al. (2003) ArticleTitleDistribution and genetic association of putative uropathogenic virulence factors, iroN, iha, kpsMT, ompT, and usp in Escherichia coli isolated from urinary tract infections in Japan J Urol 170 2490–3 Occurrence Handle14634457 Occurrence Handle10.1097/01.ju.0000094185.48467.dc

    Article  PubMed  Google Scholar 

  8. SL Chen CS Hung J Xu CS Reigstad V Magrini A Sabo et al. (2006) ArticleTitleIdentification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach Proc Natl Acad Sci U S A 103 5977–82 Occurrence Handle16585510 Occurrence Handle10.1073/pnas.0600938103 Occurrence Handle1:CAS:528:DC%2BD28XktFaitb0%3D

    Article  PubMed  CAS  Google Scholar 

  9. R Blomgran L Zheng O Stendahl (2004) ArticleTitleUropathogenic Escherichia coli triggers oxygen-dependent apoptosis in human neutrophils through the cooperative effect of type 1 fimbriae and lipopolysaccharide Infect Immun 72 4570–8 Occurrence Handle15271917 Occurrence Handle10.1128/IAI.72.8.4570-4578.2004 Occurrence Handle1:CAS:528:DC%2BD2cXmtlyms74%3D

    Article  PubMed  CAS  Google Scholar 

  10. JA Snyder BJ Haugen CV Lockatell N Maroncle EC Hagan DE Johnson et al. (2005) ArticleTitleCoordinate expression of fimbriae in uropathogenic Escherichia coli Infect Immun 73 7588–96 Occurrence Handle16239562 Occurrence Handle10.1128/IAI.73.11.7588-7596.2005 Occurrence Handle1:CAS:528:DC%2BD28XhsVGkur8%3D

    Article  PubMed  CAS  Google Scholar 

  11. G Finger D Landau (2004) ArticleTitlePathogenesis of urinary tract infections with normal female anatomy Lancet Infect Dis 4 631–5 Occurrence Handle10.1016/S1473-3099(04)01147-8

    Article  Google Scholar 

  12. FK De Graaf FR Mooi (1986) ArticleTitleThe fimbrial adhesins of Escherichia coli Adv Microb Physiol 28 65–143 Occurrence Handle2880484 Occurrence Handle1:CAS:528:DyaL2sXhsFalsLw%3D

    PubMed  CAS  Google Scholar 

  13. TA Oelschlaeger (2001) ArticleTitleAdhesins as invasins Int J Med Microbiol 291 7–14 Occurrence Handle11403413 Occurrence Handle10.1078/1438-4221-00115 Occurrence Handle1:CAS:528:DC%2BD3MXkvVOnsLY%3D

    Article  PubMed  CAS  Google Scholar 

  14. MI Garcia M Jouve JP Nataro P Gounon C Le Bouguenec (2000) ArticleTitleCharacterization of the AfaD-like family of invasins encoded by pathogenic Escherichia coli associated with intestinal and extra-intestinal infections FEBS Lett 479 111–7 Occurrence Handle10981717 Occurrence Handle10.1016/S0014-5793(00)01898-6 Occurrence Handle1:CAS:528:DC%2BD3cXls1Gisbw%3D

    Article  PubMed  CAS  Google Scholar 

  15. J Guignot MF Bernet-Camard C Pous L Plancon C Le Bouguenec AL Servin (2001) ArticleTitlePolarized entry of uropathogenic Afa/Dr diffusely adhering Escherichia coli strain IH11128 into human epithelial cells: evidence for alpha5beta1 integrin recognition and sub-sequent internalization through a pathway involving caveolae and dynamic unstable microtubules Infect Immun 69 1856–68 Occurrence Handle11179364 Occurrence Handle10.1128/IAI.69.3.1856-1868.2001 Occurrence Handle1:CAS:528:DC%2BD3MXitFGqsrk%3D

    Article  PubMed  CAS  Google Scholar 

  16. NW Gunther JA Snyder V Lockatell I Blomfield DE Johnson HL Mobley (2002) ArticleTitleAssessment of virulence of uropathogenic Escherichia coli type 1 fimbrial mutants in which the invertible element is phase-locked on or off Infect Immun 70 3344–54 Occurrence Handle10.1128/IAI.70.7.3344-3354.2002 Occurrence Handle1:CAS:528:DC%2BD38XkvV2ltb0%3D Occurrence Handle12065472

    Article  CAS  PubMed  Google Scholar 

  17. NW Gunther V Lockatell DE Johnson HL Mobley (2001) ArticleTitleIn vivo dynamics of type 1 fimbria regulation in uropathogenic Escherichia coli during experimental urinary tract infection Infect Immun 69 2838–46 Occurrence Handle11292696 Occurrence Handle10.1128/IAI.69.5.2838-2846.2001 Occurrence Handle1:CAS:528:DC%2BD3MXjtV2rtbk%3D

    Article  PubMed  CAS  Google Scholar 

  18. B Wullt G Bergsten H Connell P Rollano N Gebretsadik R Hull C Svanborg (2000) ArticleTitleP fimbriae enhance the early establishment of Escherichia coli in the human urinary tract Mol Microbiol 38 456–64 Occurrence Handle11069670 Occurrence Handle10.1046/j.1365-2958.2000.02165.x Occurrence Handle1:CAS:528:DC%2BD3cXovV2isr8%3D

    Article  PubMed  CAS  Google Scholar 

  19. A Stapleton E Nudelman H Clausen S Hakomori WE Stamm (1992) ArticleTitleBinding of uropathogenic Escherichia coli R45 to glycolipids extracted from vaginal epithelial cells is dependent on Histo-blood group secretor status J Clin Invest 90 965–72 Occurrence Handle1522244 Occurrence Handle1:CAS:528:DyaK38XmtlWqtrY%3D

    PubMed  CAS  Google Scholar 

  20. AE Stapleton MR Stroud SI Hakomori WE Stamm (1998) ArticleTitleThe globoseries glycosphingolipid sialosyl galactosyl globoside is found in urinary tract tissues and is a preferred binding receptor in vitro for uropathgenic Escherichia coli expressing pap-encoded adhesins Infect Immun 66 3856–61 Occurrence Handle9673272 Occurrence Handle1:CAS:528:DyaK1cXltFCqsL4%3D

    PubMed  CAS  Google Scholar 

  21. MR Stroud AE Stapleton SB Levery (1998) ArticleTitleThe P histo-blood group-related glycosphingolipid sialosyl galactosyl globoside as a preferred binding receptor for uropathogenic Escherichia coli: isolation and structural characterization from human kidney Biochemistry 37 17420–8 Occurrence Handle9860857 Occurrence Handle10.1021/bi9814639 Occurrence Handle1:CAS:528:DyaK1cXnsVGnurw%3D

    Article  PubMed  CAS  Google Scholar 

  22. S Ishitoya S Yamamoto K Mitsumori O Ogawa A Terai (2002) ArticleTitleNon-Secretor status is associated with female acute uncomplicated pyelonephritis BJU Int 89 851–4 Occurrence Handle12010227 Occurrence Handle10.1046/j.1464-410X.2002.02782.x Occurrence Handle1:STN:280:DC%2BD383ntV2jtA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  23. A Kanematsu S Yamamoto Y Sugita K Yoshino M Watanabe M Nomi et al. (2005) ArticleTitleRenal scarring is associated with non-secretion of blood-type antigen in children with primary vesicoureteral reflux J Urol 174 1594–7 Occurrence Handle16148660 Occurrence Handle10.1097/01.ju.0000176598.60310.90

    Article  PubMed  Google Scholar 

  24. WF Keane R Welch G Gekker PK Peterson (1987) ArticleTitleMechanism of Escherichia coli alpha-hemolysin-induced injury to isolated renal tubular cells Am J Pathol 126 350–7 Occurrence Handle3030115 Occurrence Handle1:CAS:528:DyaL2sXitFWrsbs%3D

    PubMed  CAS  Google Scholar 

  25. J De Rycke JF Guillot R Boivin (1987) ArticleTitleCytotoxins in non-enterotoxigenic strains of Escherichia coli isolated from feces of diarrheic calves Vet Microbiol 15 137–50 Occurrence Handle3326246 Occurrence Handle10.1016/0378-1135(87)90139-8 Occurrence Handle1:STN:280:BieC2cnltF0%3D

    Article  PubMed  CAS  Google Scholar 

  26. KE Rippere-Lampe AD O'Brien R Conran HA Lockman (2001) ArticleTitleMutation of the gene encoding cytotoxic necrotizing factor type 1 (cnf(1)) attenuates the virulence of uropathogenic Escherichia coli Infect Immun 69 3954–64 Occurrence Handle11349064 Occurrence Handle10.1128/IAI.69.6.3954-3964.2001 Occurrence Handle1:CAS:528:DC%2BD3MXjvFyqsro%3D

    Article  PubMed  CAS  Google Scholar 

  27. JM Davis SB Rasmussen AD O'Brien (2005) ArticleTitleCytotoxic necrotizing factor type 1 production by uropathogenic Escherichia coli modulates polymorphonuclear leukocyte function Infect Immun 73 5301–10 Occurrence Handle16113245 Occurrence Handle10.1128/IAI.73.9.5301-5310.2005 Occurrence Handle1:CAS:528:DC%2BD2MXps1Gks70%3D

    Article  PubMed  CAS  Google Scholar 

  28. M Mills KC Meysick AD O'Brien (2000) ArticleTitleCytotoxic necrotizing factor type 1 of uropathogenic Escherichia coli kills cultured human uroepithelial 5637 cells by an apoptotic mechanism Infect Immun 68 5869–80 Occurrence Handle10992497 Occurrence Handle10.1128/IAI.68.10.5869-5880.2000 Occurrence Handle1:STN:280:DC%2BD3M%2FitFWqug%3D%3D

    Article  PubMed  CAS  Google Scholar 

  29. DM Guyer S Radulovic FE Jones HL Mobley (2002) ArticleTitleSat, the secreted autotransporter toxin of uropathogenic Escherichia coli, is a vacuolating cytotoxin for bladder and kidney epithelial cells Infect Immun 70 4539–46 Occurrence Handle12117966 Occurrence Handle10.1128/IAI.70.8.4539-4546.2002 Occurrence Handle1:CAS:528:DC%2BD38XlsFCmur8%3D

    Article  PubMed  CAS  Google Scholar 

  30. DM Guyer IR Henderson JP Nataro HL Mobley (2000) ArticleTitleIdentification of sat, an autotransporter toxin produced by uropathogenic Escherichia coli Mol Microbiol 38 53–66 Occurrence Handle11029690 Occurrence Handle10.1046/j.1365-2958.2000.02110.x Occurrence Handle1:CAS:528:DC%2BD3cXnsVejsrg%3D

    Article  PubMed  CAS  Google Scholar 

  31. NH Carbonetti S Boonchai SH Parry V Vaisanen-Rhen TK Korhonen PH Williams (1986) ArticleTitleAerobactin-mediated iron uptake by Escherichia coli isolates from human extraintestinal infections Infect Immun 51 966–8 Occurrence Handle3512445 Occurrence Handle1:STN:280:BimC3sfmtlI%3D

    PubMed  CAS  Google Scholar 

  32. TA Russo UB Carlino A Mong ST Jodush (1999) ArticleTitleIdentification of genes in an extraintestinal isolate of Escherichia coli with increased expression after exposure to human urine Infect Immun 67 5306–14 Occurrence Handle10496910 Occurrence Handle1:CAS:528:DyaK1MXmsFWnu7o%3D

    PubMed  CAS  Google Scholar 

  33. RJ Bauer L Zhang B Foxman A Siitonen ME Jantunen H Saxen CF Marrs (2002) ArticleTitleMolecular epidemiology of three putative virulence genes for Escherichia coli urinary tract infection–usp, iha, and iroN(E. coli) J Infect Dis 185 1521–4 Occurrence Handle11992291 Occurrence Handle10.1086/340206 Occurrence Handle1:CAS:528:DC%2BD38XksVCjur0%3D

    Article  PubMed  CAS  Google Scholar 

  34. S Kanamaru H Kurazono S Ishitoya A Terai T Habuchi M Nakano et al. (2003) ArticleTitleDistribution and genetic association of putative uropathogenic virulence factors iroN, iha, kpsMT, ompT and usp in Escherichia coli isolated from urinary tract infections in Japan J Urol 170 2490–3 Occurrence Handle14634457 Occurrence Handle10.1097/01.ju.0000094185.48467.dc

    Article  PubMed  Google Scholar 

  35. H Kurazono S Yamamoto M Nakano GB Nair A Terai W Chaicumpa H Hayashi (2000) ArticleTitleCharacterization of a putative virulence island in the chromosome of uropathogenic Escherichia coli possessing a gene encoding a uropathogenic-specific protein Microb Pathog 28 183–9 Occurrence Handle10702359 Occurrence Handle10.1006/mpat.1999.0331 Occurrence Handle1:CAS:528:DC%2BD3cXhsVyqu7k%3D

    Article  PubMed  CAS  Google Scholar 

  36. M Nakano S Yamamoto A Terai O Ogawa SI Makino H Hayashi et al. (2001) ArticleTitleStructural and sequence diversity of the pathogenicity island of uropathogenic Escherichia coli which encodes the USP protein FEMS Microbiol Lett 205 71–6 Occurrence Handle11728718 Occurrence Handle10.1111/j.1574-6968.2001.tb10927.x Occurrence Handle1:CAS:528:DC%2BD3MXos1Kisrk%3D

    Article  PubMed  CAS  Google Scholar 

  37. S Yamamoto M Nakano A Terai K Yuri K Nakata GB Nair et al. (2001) ArticleTitleThe presence of the virulence island containing the usp gene in uropathogenic Escherichia coli is associated with urinary tract infection in an experimental mouse model J Urol 165 1347–51 Occurrence Handle11257714 Occurrence Handle10.1016/S0022-5347(01)69897-5 Occurrence Handle1:CAS:528:DC%2BD3MXisVygsL4%3D

    Article  PubMed  CAS  Google Scholar 

  38. AH Parret R De Mot (2002) ArticleTitle Escherichia coli's uropathogenic-specific protein: a bacteriocin promoting infectivity? Microbiology 148 1604–6 Occurrence Handle12055281 Occurrence Handle1:CAS:528:DC%2BD38XkvVCgsrk%3D

    PubMed  CAS  Google Scholar 

  39. C Hughes R Phillips AP Roberts (1982) ArticleTitleSerum resistance among Escherichia coli strains causing urinary tract infection in relation to O type and the carriage of hemolysin, colicin, and antibiotic resistance determinants Infect Immun 35 270–5 Occurrence Handle7033137 Occurrence Handle1:STN:280:Bi2D1Mjit1E%3D

    PubMed  CAS  Google Scholar 

  40. V Vaisanen-Rhen J Elo E Vaisanen A Siitonen I Orskov F Orskov et al. (1984) ArticleTitleP-fimbriated clones among uropathogenic Escherichia coli strains Infect Immun 43 149–55 Occurrence Handle6140222 Occurrence Handle1:STN:280:BiuD1cnotVI%3D

    PubMed  CAS  Google Scholar 

  41. M Achtman A Mercer B Kusecek A Pohl M Heuzenroeder W Aaronson et al. (1983) ArticleTitleSix widespread bacterial clones among Escherichia coli K1 isolates Infect Immun 39 315–35 Occurrence Handle6218094 Occurrence Handle1:CAS:528:DyaL3sXmvVGnsg%3D%3D

    PubMed  CAS  Google Scholar 

  42. B Kusecek H Wloch A Mercer V Vaisanen G Pluschke T Korhonen M Achtman (1984) ArticleTitleLipopolysaccharide, capsule, and fimbriae as virulence factors among O1, O7, O16, O18, or O75 and K1, K5, or K100 Escherichia coli Infect Immun 43 368–79 Occurrence Handle6140224 Occurrence Handle1:CAS:528:DyaL2cXotlynsg%3D%3D

    PubMed  CAS  Google Scholar 

  43. PJ Herzer S Inouye M Inouye TS Whittam (1990) ArticleTitlePhylogenetic distribution of branched RNA-linked multicopy single-stranded DNA among natural isolates of Escherichia coli J Bacteriol 172 6175–81 Occurrence Handle1699928 Occurrence Handle1:CAS:528:DyaK3MXjtFGr

    PubMed  CAS  Google Scholar 

  44. B Picard JS Garcia S Gouriou P Duriez N Brahimi E Bingen et al. (1999) ArticleTitleThe link between phylogeny and virulence in Escherichia coli extraintestinal infection Infect Immun 67 546–53 Occurrence Handle9916057 Occurrence Handle1:CAS:528:DyaK1MXotlalug%3D%3D

    PubMed  CAS  Google Scholar 

  45. S Kanamaru H Kurazono M Nakano A Terai O Ogawa S Yamamoto (2006) ArticleTitleSubtyping of uropathogenic Escherichia coli according to the pathogenicity island encoding uropathogenic-specific protein: comparison with phylogenetic groups Int J Urol 13 754–60 Occurrence Handle16834656 Occurrence Handle10.1111/j.1442-2042.2006.01398.x Occurrence Handle1:CAS:528:DC%2BD28XotFartL8%3D

    Article  PubMed  CAS  Google Scholar 

  46. TA Stamey M Timothy M Millar G Mihara (1971) ArticleTitleRecurrent urinary infections in adult women. The role of introital enterobacteria Calif Med 115 1–19 Occurrence Handle5105794 Occurrence Handle1:STN:280:CS6B2sfis1A%3D

    PubMed  CAS  Google Scholar 

  47. RN Gruneberg (1969) ArticleTitleRelationship of infecting urinary organism to the faecal flora in patients with symptomatic urinary infection Lancet II 766–8 Occurrence Handle10.1016/S0140-6736(69)90478-4

    Article  Google Scholar 

  48. S Yamamoto T Tsukamoto A Terai H Kurazono Y Takeda O Yoshida (1997) ArticleTitleGenetic evidence supporting the fecal-perineal-urethral hypothesis in cystitis caused by Escherichia coli J Urol 157 1127–9 Occurrence Handle9072556 Occurrence Handle10.1016/S0022-5347(01)65154-1 Occurrence Handle1:STN:280:ByiC1cfovVM%3D

    Article  PubMed  CAS  Google Scholar 

  49. K Mitsumori A Terai S Yamamoto O Yoshida (1997) ArticleTitleVirulence characteristics and DNA fingerprints of Escherichia coli isolated from women with acute uncomplicated pyelonephritis J Urol 158 2329–32 Occurrence Handle9366385 Occurrence Handle10.1016/S0022-5347(01)68244-2 Occurrence Handle1:CAS:528:DyaK1cXmsVOqsrY%3D

    Article  PubMed  CAS  Google Scholar 

  50. A Terai S Ishitoya K Mitsumori O Ogawa (2000) ArticleTitleMolecular epidemiological evidence for ascending urethral infection in acute bacterial prostatitis J Urol 164 1945–7 Occurrence Handle11061888 Occurrence Handle10.1016/S0022-5347(05)66925-X Occurrence Handle1:STN:280:DC%2BD3M%2Fns1CmtA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  51. B Foxman L Zhang P Tallman BC Andree AM Geiger JS Koopman et al. (1997) ArticleTitleTransmission of uropathogens between sex partners J Infect Dis 175 989–92 Occurrence Handle9086166 Occurrence Handle1:STN:280:ByiB2c%2FntVI%3D Occurrence Handle10.1086/514007

    Article  PubMed  CAS  Google Scholar 

  52. JR Johnson MA Kuskowski A Gajewski S Soto JP Horcajada MT Jimenez de Anta J Vila (2005) ArticleTitleExtended virulence genotypes and phylogenetic background of Escherichia coli isolates from patients with cystitis, pyelonephritis, or prostatitis J Infect Dis 191 46–50 Occurrence Handle15593002 Occurrence Handle10.1086/426450

    Article  PubMed  Google Scholar 

  53. J Ruiz K Simon JP Horcajada M Velasco M Barranco G Roig et al. (2002) ArticleTitleDifferences in virulence factors among clinical isolates of Escherichia coli causing cystitis and pyelonephritis in women and prostatitis in men J Clin Microbiol 40 4445–9 Occurrence Handle12454134 Occurrence Handle10.1128/JCM.40.12.4445-4449.2002 Occurrence Handle1:CAS:528:DC%2BD38Xps1ygsrc%3D

    Article  PubMed  CAS  Google Scholar 

  54. S Kanamaru H Kurazono A Terai K Monden H Kumon Y Mizunoe et al. (2006) ArticleTitleIncreased biofilm formation in Escherichia coli isolated from acute prostatitis Int J Antimicrob Agents 28 S21–5 Occurrence Handle16828264 Occurrence Handle10.1016/j.ijantimicag.2006.05.006 Occurrence Handle1:CAS:528:DC%2BD28XotVyktLY%3D

    Article  PubMed  CAS  Google Scholar 

  55. S Marild B Wettergren M Hellstrom U Jodal K Lincoln I Orskov et al. (1988) ArticleTitleBacterial virulence and inflammatory response in infants with febrile urinary tract infection or screening bacteriuria J Pediatr 112 348–54 Occurrence Handle3279175 Occurrence Handle10.1016/S0022-3476(88)80311-1 Occurrence Handle1:STN:280:BieC2MrhsVE%3D

    Article  PubMed  CAS  Google Scholar 

  56. RA Hull DC Rudy IE Wieser WH Donovan (1998) ArticleTitleVirulence factors of Escherichia coli isolates from patients with symptomatic and asymptomatic bacteriuria and neuropathic bladders due to spinal cord and brain injuries J Clin Microbiol 36 115–7 Occurrence Handle9431932 Occurrence Handle1:STN:280:DyaK1c%2Fpt1ahuw%3D%3D

    PubMed  CAS  Google Scholar 

  57. JC Graham JB Leathart SJ Keegan J Pearson A Bint DL Gally (2001) ArticleTitleAnalysis of Escherichia coli strains causing bacteriuria during pregnancy: selection for strains that do not express type 1 fimbriae Infect Immun 69 794–9 Occurrence Handle11159970 Occurrence Handle10.1128/IAI.69.2.794-799.2001 Occurrence Handle1:CAS:528:DC%2BD3MXns1Srtw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  58. J Vila K Simon J Ruiz JP Horcajada M Velasco M Barranco et al. (2002) ArticleTitleAre quinolone-resistant uropathogenic Escherichia coli less virulent? J Infect Dis 186 1039–42 Occurrence Handle12232848 Occurrence Handle10.1086/342955 Occurrence Handle1:CAS:528:DC%2BD38Xot1Gnsbk%3D

    Article  PubMed  CAS  Google Scholar 

  59. A Takahashi S Kanamaru H Kurazono Y Kunishima T Tsukamoto O Ogawa S Yamamoto (2006) ArticleTitle Escherichia coli isolates associated with uncomplicated and complicated cystitis and asymptomatic bacteriuria possess similar phylogenies, virulence genes, and O-serogroup profiles J Clin Microbiol 44 4589–92 Occurrence Handle17065267 Occurrence Handle10.1128/JCM.02070-06 Occurrence Handle1:CAS:528:DC%2BD2sXmslKhsw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  60. C Svanborg G Bergsten H Fischer G Godaly M Gustafsson D Karpman et al. (2006) ArticleTitleUropathogenic Escherichia coli as a model of host-parasite interaction Curr Opin Microbiol 9 33–9 Occurrence Handle16406777 Occurrence Handle10.1016/j.mib.2005.12.012 Occurrence Handle1:CAS:528:DC%2BD28XhtFSitbc%3D

    Article  PubMed  CAS  Google Scholar 

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  1. The Department of Urology, Hyogo College of Medicine, 1-1 Mukogawacho, Nishinomiya, Hyogo, 663-8501, Japan

    Shingo Yamamoto

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  1. Shingo Yamamoto
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Yamamoto, S. Molecular epidemiology of uropathogenic Escherichia coli . J Infect Chemother 13, 68–73 (2007). https://doi.org/10.1007/s10156-007-0506-y

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