References
Barina A, De Paoli A, Delrio P et al (2017) Rectal sparing approach after preoperative radio- and/or chemotherapy (RESARCH) in patients with rectal cancer: a multicentre observational study. Tech Coloproctol. doi:10.1007/s10151-017-1665-1
Habr-Gama A, Gama-Rodrigues J, Perez RO (2013) Is tailoring treatment of rectal cancer the only true benefit of long-course neoadjuvant chemoradiation? Dis Colon Rectum 56:264–266
Habr-Gama A, Sao Juliao GP, Gama-Rodrigues J et al (2017) Baseline T classification predicts early tumor regrowth after nonoperative management in distal rectal cancer after extended neoadjuvant chemoradiation and initial complete clinical response. Dis Colon Rectum 60:586–594
Das P, Skibber JM, Rodriguez-Bigas MA et al (2007) Predictors of tumor response and downstaging in patients who receive preoperative chemoradiation for rectal cancer. Cancer 109:1750–1755
Garcia-Aguilar J, Renfro LA, Chow OS et al (2015) Organ preservation for clinical T2N0 distal rectal cancer using neoadjuvant chemoradiotherapy and local excision (ACOSOG Z6041): results of an open-label, single-arm, multi-institutional, phase 2 trial. Lancet Oncol 16:1537–1546
Rullier E, Rouanet P, Tuech JJ et al (2017) Organ preservation for rectal cancer (GRECCAR 2): a prospective, randomised, open-label, multicentre, phase 3 trial. Lancet 390(10093):469–479
Habr-Gama A, Sao Juliao GP, Vailati BB et al (2017) Organ preservation in cT2N0 rectal cancer after neoadjuvant chemoradiation therapy: the impact of radiation therapy dose-escalation and consolidation chemotherapy. Ann Surg. doi:10.1097/SLA.0000000000002447
Appelt AL, Ploen J, Vogelius IR, Bentzen SM, Jakobsen A (2013) Radiation dose-response model for locally advanced rectal cancer after preoperative chemoradiation therapy. Int J Radiat Oncol Biol Phys 85:74–80
Garcia-Aguilar J, Chow OS, Smith DD et al (2015) Effect of adding mFOLFOX6 after neoadjuvant chemoradiation in locally advanced rectal cancer: a multicentre, phase 2 trial. Lancet Oncol 16:957–966
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Perez, R.O., Habr-Gama, A., São Julião, G.P. et al. Rectal sparing approach after preoperative radio- and/or chemotherapy (RESARCH) in patients with rectal cancer: potential pitfalls of a multicentre observational study. Tech Coloproctol 22, 141–142 (2018). https://doi.org/10.1007/s10151-017-1686-9
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DOI: https://doi.org/10.1007/s10151-017-1686-9