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Long-term evaluation of bulking agents for the treatment of fecal incontinence: clinical outcomes and ultrasound evidence

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Abstract

Background

The injection of bulking agents into the anal canal has been reported to help patients with fecal incontinence. Although it has been advocated as a safe and effective option, substantial data concerning long-term efficacy are still lacking, and the resorption process of the implants has not yet been carefully studied. The aim of our study was to investigate the long-term outcomes of bulking agents for the treatment of fecal incontinence and the behavior of implanted materials in the anorectum.

Methods

At a median follow-up of 7 years, 19 patients with idiopathic fecal incontinence who had received bulking agent implants were evaluated. Clinical, manometric and ultrasound assessments were carried out.

Results

The clinical improvements that were achieved in the short term were not maintained over time. For each patient, the number of implants that could no longer be identified on ultrasound was significantly correlated with poorer clinical long-term outcomes. On average, only 14 % of the originally injected volume was still detectable.

Conclusions

In the long term, perianally injected bulking agents seem to lose effectiveness. The ultrasound assessment suggests that the process of resorption is almost complete, and the implants are no longer effective in treating incontinence.

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Acknowledgments

Dr Guerra wishes to thank both Dr Marco Bisello, one of his mentors in coloproctology, and Dr Francesco Antonio Polistina for their helpful review and comments.

Conflict of interest

None.

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Authors and Affiliations

  1. Department of Surgery, Umberto I Hospital, Viale del Policlinico 155, 00161, Rome, Italy

    F. Guerra, G. Giuliani, D. Coletta, S. Amore Bonapasta, F. Velluti & F. La Torre

  2. Department of Surgery, Sant’Andrea Hospital, Via di Grottarossa 1035/1039, 00189, Rome, Italy

    M. La Torre

  3. Via dei Sabelli 211, 00185, Rome, Italy

    F. Guerra

Authors
  1. F. Guerra
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  2. M. La Torre
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  3. G. Giuliani
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  4. D. Coletta
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  5. S. Amore Bonapasta
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  6. F. Velluti
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  7. F. La Torre
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Corresponding author

Correspondence to F. Guerra.

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Guerra, F., La Torre, M., Giuliani, G. et al. Long-term evaluation of bulking agents for the treatment of fecal incontinence: clinical outcomes and ultrasound evidence. Tech Coloproctol 19, 23–27 (2015). https://doi.org/10.1007/s10151-014-1236-7

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  • DOI: https://doi.org/10.1007/s10151-014-1236-7

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