Abstract
We report a case of hepatocellular carcinoma associated with mesenchymal differentiation, which was identified as a true carcinosarcoma based on thorough pathologic examination. A 48-year-old man presented with a giant mass in the lateral segment of the liver. It was resected by lateral segmentectomy combined with total gastrectomy. Microscopically, the tumor consisted of hepatocellular carcinoma, osteosarcoma, and undifferentiated sarcomatous components. The undifferentiated sarcomatous components were positive for cytokeratin, whereas the osteosarcomatous components were negative for cytokeratin and positive for S100. To our knowledge, this is only the second known case in which mesenchymal differentiation was immunohistochemically demonstrated in liver carcinosarcoma.
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Received: May 21, 1998 / Accepted: October 28, 1998
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Aiko, S., Sugiura, Y., Yoshizumi, Y. et al. Carcinosarcoma of the liver with an osteosarcomatous component. Int J Clin Oncol 4, 185–188 (1999). https://doi.org/10.1007/s101470050051
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DOI: https://doi.org/10.1007/s101470050051