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Low preoperative serum cholesterol level is associated with aggressive pathologic features and poor cancer-specific survival in patients with surgically treated renal cell carcinoma

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Abstract

Background

The prognostic implications of preoperative serum total cholesterol (TC) level in patients with renal cell carcinoma (RCC) remain poorly understood. We investigated the prognostic role of preoperative serum TC in patients with surgically treated RCC from a large, multi-institutional Korean collaboration.

Patients and methods

A database of 3064 patients with RCC who underwent radical or partial nephrectomy between 1999 and 2011 at eight academic centers was analyzed. Preoperative serum TC levels were measured in fasting blood samples.

Results

Low preoperative serum TC level was associated with aggressive tumor characteristics, including large tumor size, advanced stage, high nuclear grade, lymph node involvement, and sarcomatous differentiation (all P < 0.001). Low TC level was associated with poor recurrence-free or cancer-specific survival (CSS) in the entire cohort, whereas the significance of the association changed after stratification by disease stage and histologic subtype. Multivariate Cox regression analysis showed that preoperative TC, as a continuous or categorical variable, was an independent predictor of CSS.

Conclusions

Preoperative low serum TC level was associated with aggressive tumor characteristics and poor CSS in patients with surgically treated RCC. Preoperative TC may provide additional guidance regarding the choice of therapeutic strategies to improve prognosis.

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Acknowledgments

This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2015R1D1A1A01057786).

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Authors and Affiliations

  1. Department of Urology, Chungbuk National University College of Medicine, 1st Chungdae-ro, Seowon-gu, Cheongju, Chungbuk, 28644, South Korea

    Ho Won Kang, Sung Pil Seo, Won Tae Kim, Seok Joong Yun, Sang-Cheol Lee, Wun-Jae Kim & Yong-June Kim

  2. Department of Urology, Chungbuk National University Hospital, Cheongju, South Korea

    Ho Won Kang, Sung Pil Seo, Won Tae Kim, Seok Joong Yun, Sang-Cheol Lee, Wun-Jae Kim & Yong-June Kim

  3. Department of Urology, Chonnam National University Hwasun Hospital, Gwangju, Jeonnam, South Korea

    Eu Chang Hwang

  4. Department of Urology, Korea University School of Medicine, Seoul, South Korea

    Seok Ho Kang

  5. Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, South Korea

    Sung-Hoo Hong

  6. Department of Urology, National Cancer Center, Goyang, South Korea

    Jinsoo Chung

  7. Department of Urology, Kyungpook National University College of Medicine, Daegu, South Korea

    Tae Gyun Kwon

  8. Department of Urology, Seoul National University College of Medicine, Seoul, South Korea

    Hyeon Hoe Kim & Cheol Kwak

  9. Department of Urology, Seoul National University Bundang Hospital, 166 Gumi-ro, Bundang-gu, Seongnam, Kyunggi-do, 463-707, South Korea

    Seok-Soo Byun

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  1. Ho Won Kang
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  2. Sung Pil Seo
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  8. Seok Ho Kang
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  14. Seok-Soo Byun
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  15. Yong-June Kim
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Consortia

The KORCC (KOrean Renal Cell Carcinoma) group

Corresponding authors

Correspondence to Seok-Soo Byun or Yong-June Kim.

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The authors have no potential conflicts of interest to disclose.

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Cite this article

Kang, H.W., Seo, S.P., Kim, W.T. et al. Low preoperative serum cholesterol level is associated with aggressive pathologic features and poor cancer-specific survival in patients with surgically treated renal cell carcinoma. Int J Clin Oncol 23, 142–150 (2018). https://doi.org/10.1007/s10147-017-1172-4

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  • DOI: https://doi.org/10.1007/s10147-017-1172-4

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