Abstract
Background
The postoperative complication is one of an indicator of poor prognosis in patients with several gastroenterological cancers after curative operations. We, herein, examined prognostic impacts of postoperative complications in patients with intrahepatic cholangiocarcinoma after curative operations.
Methods
We retrospectively analyzed 60 patients with intrahepatic cholangiocarcinoma who underwent primary curative operations from June 2002 to February 2016. Prognostic impacts of postoperative complications were analyzed using log-rank test and Cox proportional hazard model.
Results
Postoperative complications (Clavien-Dindo classification grade 3 or more) occurred in 13 patients (21.7%). Overall survival of patients without postoperative complications was significantly better than that of patients with postoperative complications (p = 0.025). Postoperative complications are independent prognostic factor of overall survival (hazard ratio 3.02; p = 0.030). In addition, bile duct resection and reconstruction (Odds ratio 59.1; p = 0.002) and hepatitis C virus antibody positive (Odds ratio 7.14; p= 0.022), and lymph node dissection (Odds ratio 6.28; p = 0.040) were independent predictors of postoperative complications.
Conclusion
Postoperative complications may be an independent predictor of poorer survival in patients with intrahepatic cholangiocarcinoma after curative operations. Lymph node dissection and bile duct resection and reconstruction were risk factors for postoperative complications, therefore we should pay attentions to perform lymph node dissections, bile duct resection and reconstruction in patients with intrahepatic cholangiocarcinoma.
Similar content being viewed by others
References
Khan SA, Taylor-Robinson SD, Toledano MB et al (2002) Changing international trends in mortality rates for liver, biliary and pancreatic tumours. J Hepatol 37:806–813
Ikai I, Arii S, Okazaki M et al (2007) Report of the 17th nationwide follow-up survey of primary liver cancer in Japan. Hepatol Res 37:676–691
Shaib YH, Davila JA, McGlynn K et al (2004) Rising incidence of intrahepatic cholangiocarcinoma in the United States: a true increase? J Hepatol 40:472–477
Taylor-Robinson SD, Toledano MB, Arora S et al (2001) Increase in mortality rates from intrahepatic cholangiocarcinoma in England and Wales 1968-1998. Gut 48:816–820
de Jong MC, Nathan H, Sotiropoulos GC et al (2011) Intrahepatic cholangiocarcinoma: an international multi-institutional analysis of prognostic factors and lymph node assessment. J Clin Oncol 29:3140–3145
Shimada M, Yamashita Y, Aishima S et al (2001) Value of lymph node dissection during resection of intrahepatic cholangiocarcinoma. Br J Surg 88:1463–1466
Matsuda A, Matsumoto S, Seya T et al (2013) Does postoperative complication have a negative impact on long-term outcomes following hepatic resection for colorectal liver metastasis?: a meta-analysis. Ann Surg Oncol 20:2485–2492
Merkow RP, Bilimoria KY, Tomlinson JS et al (2014) Postoperative complications reduce adjuvant chemotherapy use in resectable pancreatic cancer. Ann Surg 260:372–377
Baba Y, Yoshida N, Shigaki H et al (2016) Prognostic impact of postoperative complications in 502 patients with surgically resected esophageal squamous cell carcinoma: a retrospective single-institution study. Ann Surg 264:305–311
Balkwill F, Mantovani A (2001) Inflammation and cancer: back to Virchow? Lancet 357:539–545
Doussot A, Lim C, Gomez Gavara C et al (2016) Multicentre study of the impact of morbidity on long-term survival following hepatectomy for intrahepatic cholangiocarcinoma. Br J Surg 103:1887–1894
Dindo D, Demartines N, Clavien PA (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240:205–213
Adachi T, Eguchi S, Beppu T et al (2015) Prognostic Impact of Preoperative Lymph Node Enlargement in Intrahepatic Cholangiocarcinoma: a multi-institutional study by the Kyushu study group of liver surgery. Ann Surg Oncol 22:2269–2278
Hyder O, Marques H, Pulitano C et al (2014) A nomogram to predict long-term survival after resection for intrahepatic cholangiocarcinoma: an Eastern and Western experience. JAMA Surg 149:432–438
Spolverato G, Yakoob MY, Kim Y et al (2015) Impact of complications on long-term survival after resection of intrahepatic cholangiocarcinoma. Cancer 121:2730–2739
Sharma P, Zargar H, Spiess PE (2016) Surgical advances in inguinal lymph node dissection: optimizing treatment outcomes. Urol Clin North Am 43:457–468
Kilgore LC, Partridge EE, Alvarez RD et al (1995) Adenocarcinoma of the endometrium: survival comparisons of patients with and without pelvic node sampling. Gynecol Oncol 56:29–33
Frost JA, Webster KE, Bryant A et al (2015) Lymphadenectomy for the management of endometrial cancer. Cochrane Database Syst Rev (9):CD007585. doi:10.1002/14651858.CD007585.pub3
Kang J, Hur H, Min BS et al (2011) Prognostic impact of inferior mesenteric artery lymph node metastasis in colorectal cancer. Ann Surg Oncol 18:704–710
Baba Y, Watanabe M, Shigaki H et al (2013) Negative lymph-node count is associated with survival in patients with resected esophageal squamous cell carcinoma. Surgery 153:234–241
Tsai HL, Huang CW, Yeh YS et al (2016) Factors affecting number of lymph nodes harvested and the impact of examining a minimum of 12 lymph nodes in stage I–III colorectal cancer patients: a retrospective single institution cohort study of 1167 consecutive patients. BMC Surg 16:17
Yamashita Y, Taketomi A, Morita K et al (2008) The impact of surgical treatment and poor prognostic factors for patients with intrahepatic cholangiocarcinoma: retrospective analysis of 60 patients. Anticancer Res 28:2353–2359
Weber SM, Ribero D, O’Reilly EM et al (2015) Intrahepatic cholangiocarcinoma: expert consensus statement. HPB (Oxford) 17:669–680
Aishima S, Kuroda Y, Nishihara Y et al (2007) Proposal of progression model for intrahepatic cholangiocarcinoma: clinicopathologic differences between hilar type and peripheral type. Am J Surg Pathol 31:1059–1067
Chok KS, Ng KK, Poon RT et al (2009) Impact of postoperative complications on long-term outcome of curative resection for hepatocellular carcinoma. Br J Surg 96:81–87
Kusano T, Sasaki A, Kai S et al (2009) Predictors and prognostic significance of operative complications in patients with hepatocellular carcinoma who underwent hepatic resection. Eur J Surg Oncol 35:1179–1185
Ruan DY, Lin ZX, Li Y et al (2015) Poor oncologic outcomes of hepatocellular carcinoma patients with intra-abdominal infection after hepatectomy. World J Gastroenterol 21:5598–5606
Wong VK, Malik HZ, Hamady ZZ et al (2007) C-reactive protein as a predictor of prognosis following curative resection for colorectal liver metastases. Br J Cancer 96:222–225
Lundy J, Ford CM (1983) Surgery, trauma and immune suppression. Evolving the mechanism. Ann Surg 197:434–438
Wortel CH, van Deventer SJ, Aarden LA et al (1993) Interleukin-6 mediates host defense responses induced by abdominal surgery. Surgery 114:564–570
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors have no conflicts of interest to declare.
About this article
Cite this article
Miyata, T., Yamashita, Yi., Yamao, T. et al. Prognostic impacts of postoperative complications in patients with intrahepatic cholangiocarcinoma after curative operations. Int J Clin Oncol 22, 526–532 (2017). https://doi.org/10.1007/s10147-017-1099-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10147-017-1099-9