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Cervical stromal involvement can predict survival in advanced endometrial carcinoma: a review of 67 patients

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Abstract

Purpose

To assess clinical, surgical and pathologic variables in survival of advanced endometrial cancer.

Methods

Sixty-seven advanced-stage (stages III and IV according to FIGO 2009) endometrial cancer cases were evaluated retrospectively. The effects on survival of age, histologic subtype, stage, grade, myometrial invasion, optimal cytoreduction, parity and cervical involvement were analyzed.

Results

Cervical involvement (P = 0.033) and nulliparity (P = 0.042) were worsening features in terms of survival. In 56 cases (83.5%) optimal cytoreduction could be achieved and survival was significantly longer in this group than the group who were not optimally cytoreduced (mean 30.4 vs. 9.6 months) (P < 0.01). Depth of myometrial invasion, histologic type of tumor, stage, grade, and age younger or older than 60 years were not found to be related to survival. Neither adjuvant therapy type nor their combination were superior to each other for improving survival.

Conclusions

Cervical stromal involvement is a poor prognostic factor in cases of advanced endometrial carcinoma. Further studies are required to describe the effect of different surgical approaches such as radical hysterectomy on survival in the presence of cervical stromal invasion.

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References

  1. Aalders JG, Abeler V, Kolstad P (1984) Clinical (stage III) as compared to subclinical intrapelvic extrauterine tumor spread in endometrial carcinoma: a clinical and histopathological study of 175 patients. Gynecol Oncol 17:64–74

    Article  PubMed  CAS  Google Scholar 

  2. Greven KM, Curran WJ Jr, Whittington R et al (1989) Analysis of failure patterns in stage III endometrial carcinoma and therapeutic implications. Int J Radiat Oncol Biol Phys 17:35–39

    Article  PubMed  CAS  Google Scholar 

  3. Goff BA, Goodman A, Muntz HG et al (1994) Surgical stage IV endometrial carcinoma: a study of 47 cases. Gynecol Oncol 52:237–240

    Article  PubMed  CAS  Google Scholar 

  4. Chi DS, Welshinger M, Venkatraman ES et al (1997) The role of surgical cytoreduction in stage IV endometrial carcinoma. Gynecol Oncol 67:56–60

    Article  PubMed  CAS  Google Scholar 

  5. Bristow RE, Zerbe MJ, Rosenshein NB et al (2000) Stage IVB endometrial carcinoma: the role of cytoreductive surgery and determinants of survival. Gynecol Oncol 78:85–91

    Article  PubMed  CAS  Google Scholar 

  6. Ayhan A, Taskiran C, Celik C et al (2002) The influence of cytoreductive surgery on survival and morbidity in stage IVB endometrial cancer. Int J Gynecol Cancer 12:448–453

    Article  PubMed  CAS  Google Scholar 

  7. Numazaki R, Miyagi E, Konnai K et al (2009) Analysis of stage IVB endometrial carcinoma patients with distant metastasis: a review of prognoses in 55 patients. Int J Clin Oncol 14:344–350

    Article  PubMed  Google Scholar 

  8. van Wijk FH, Huikeshoven FJ, Abdulkadir L et al (2006) Stage III and IV endometrial cancer: a 20-year review of patients. Int J Gynecol Cancer 16:1648–1655

    Article  PubMed  Google Scholar 

  9. Orezzoli JP, Sioletic S, Olawaiye A et al (2009) Stage II endometrioid adenocarcinoma of the endometrium: clinical implications of cervical stromal invasion. Gynecol Oncol 113:316–323

    Article  PubMed  Google Scholar 

  10. Barakat RR, Park RC, Grigsby PW et al (1997) Corpus. Epithelial tumors. In: Hoskins WJ, Perez CA, Young RC (eds) Principles and practice of gynecologic oncology, 2nd edn. Lippincott-Raven, Philadelphia, pp 859–896

  11. Fotiou S, Vlahos N, Kondi-Pafiti A et al (2009) Intraoperative gross assessment of myometrial invasion and cervical involvement in endometrial cancer: role of tumor grade and size. Gynecol Oncol 112:517–520

    Article  PubMed  Google Scholar 

  12. Lee TS, Kim JW, Kim DY et al (2010) Necessity of radical hysterectomy for endometrial cancer patients with cervical invasion. J Korean Med Sci 25:552–556

    Article  PubMed  Google Scholar 

  13. Albrektsen G, Heuch I, Wik E et al (2009) Parity and time interval since childbirth influence survival in endometrial cancer patients. Int J Gynecol Cancer 19:665–669

    Article  PubMed  Google Scholar 

  14. Behbakht K, Yordan EL, Casey C et al (1994) Prognostic indicators of survival in advanced endometrial cancer. Gynecol Oncol 55:363–367

    Article  PubMed  CAS  Google Scholar 

  15. Pliskow S, Penalver M, Averette HE (1990) Stage III and stage IV endometrial carcinoma: a review of 41 cases. Gynecol Oncol 38:210–215

    Article  PubMed  CAS  Google Scholar 

  16. Randall ME, Filiaci VL, Muss H et al (2006) Randomized phase III trial of whole-abdominal irradiation versus doxorubicin and cisplatin chemotherapy in advanced endometrial carcinoma: a Gynecologic Oncology Group Study. J Clin Oncol 24:36–44

    Article  PubMed  CAS  Google Scholar 

  17. Maggi R, Lissoni A, Spina F et al (2006) Adjuvant chemotherapy vs. radiotherapy in high-risk endometrial carcinoma: results of a randomized trial. Br J Cancer 95:266–271

    Article  PubMed  CAS  Google Scholar 

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Conflict of interest

No author has any conflict of interest.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Medical School of Ankara University, Ankara, Turkey

    Salih Taşkın, Fırat Ortaç, Korhan Kahraman & Göksu Göç

  2. Department of Biostatistics, Medical School of Ankara University, Ankara, Turkey

    Derya Öztuna

  3. Department of Obstetrics and Gynecology, Medical School of Acıbadem University, Istanbul, Turkey

    Mete Güngör

  4. Ankara Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum Anabilim Dalı, 06100, Cebeci, Ankara, Turkey

    Salih Taşkın

Authors
  1. Salih Taşkın
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  2. Fırat Ortaç
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  3. Korhan Kahraman
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  4. Göksu Göç
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  5. Derya Öztuna
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Corresponding author

Correspondence to Salih Taşkın.

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Taşkın, S., Ortaç, F., Kahraman, K. et al. Cervical stromal involvement can predict survival in advanced endometrial carcinoma: a review of 67 patients. Int J Clin Oncol 18, 105–109 (2013). https://doi.org/10.1007/s10147-011-0351-y

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  • DOI: https://doi.org/10.1007/s10147-011-0351-y

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