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Pulmonary metastasectomy in patients with renal cell carcinoma: a single-institution experience

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Abstract

Background

Pulmonary metastasectomy in patients with renal cell carcinoma (RCC) remains controversial. The purpose of our analysis was to explore the outcome of patients with RCC who underwent pulmonary metastasectomy at our institution.

Methods

We reviewed data on 25 patients who underwent resection of lung metastasis from 1998 to 2008 at our institution.

Results

All patients were treated by radical nephrectomy for primary RCC. Progression-free survival (PFS) ranged from 0.3 to 198.8 months (median 7.4 months), and overall survival (OS) ranged from 2.4 to 198.8 months (median 33.9 months). The 5-year PFS rate was 24.9%, and the OS rate was 35.5%. Although differences in the resectability of the metastasectomy and OS were not significant in univariate or multivariate analyses, the relationship between PFS and the radicality of pulmonary metastasectomy was significant in both the univariate and multivariate analyses (P = 0.004, 0.012, respectively).

Conclusions

The results of pulmonary metastasectomy for patients with RCC at our institution indicate that pulmonary metastasectomy should be performed only when the pulmonary metastasis can be completely resected. Additional studies are therefore necessary to evaluate the prognostic factors and to determine the selection criteria for pulmonary metastasectomy in the new era of molecular-targeted agents.

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References

  1. Henriksson C, Haraldsson G, Aldenborg F et al (1992) Skeletal metastases in 102 patients evaluated before surgery for renal cell carcinoma. Scand J Urol Nephrol 26:363–366

    Article  PubMed  CAS  Google Scholar 

  2. Giuliani L, Giberti C, Martorana G et al (1990) Radical extensive surgery for renal cell carcinoma: long-term results and prognostic factors. J Urol 143:468–474

    PubMed  CAS  Google Scholar 

  3. de Kernion JB, Ramming KP, Smith RB (1978) The natural history of metastatic renal cell carcinoma: a computer analysis. J Urol 120:48

    Google Scholar 

  4. Cohen HT, McGovern FJ (2005) Renal-cell carcinoma. N Engl J Med 353:2477–2490

    Google Scholar 

  5. Bellmunt J, Montagut C, Albiol et al (2007) Present strategies in the treatment of metastatic renal cell carcinoma: an update on molecular targeting agents. BJU Int 99:274–280

  6. Lane BR, Rini Bi, Novick AC et al (2007) Targeted molecular therapy for renal cell carcinoma. Urology 69:3–10

    Article  PubMed  Google Scholar 

  7. Akaza H, Tsukamoto T, Murai M et al (2007) Phase II study to investigate the efficacy, safety, and pharmacokinetics of sorafenib in Japanese patients with advanced renal cell carcinoma. Jpn J Clin Oncol 37:755–762

    Article  PubMed  Google Scholar 

  8. Barney JD, Churchill EJ (1939) Adenocarcinoma of the kidney with metastases to the lung. J Urol 42:269–276

    Google Scholar 

  9. van der Poel HG, Roukema JA, Horenblas S et al (1999) Metastasectomy in renal cell carcinoma: a multicenter retrospective analysis. Eur Urol 35:197–203

    Article  PubMed  Google Scholar 

  10. Hofmann HS, Neef H, Krohe K et al (2005) Prognostic factors and survival after pulmonary resection of metastatic renal cell carcinoma. Eur Urol 48:77–82

    Article  PubMed  Google Scholar 

  11. Assouad J, Petkova B, Berna P et al (2007) Renal cell carcinoma lung metastases: pathologic findings and prognostic factors. Ann Thorac Surg 84:1114–1120

    Article  PubMed  Google Scholar 

  12. Chen F, Fujinaga T, Shoji T et al (2008) Pulmonary resection for metastasis from renal cell carcinoma. Interact Cardiovasc Thorac Surg 7:825–828

    Article  PubMed  Google Scholar 

  13. Kanazaki R, Higashiyama M, Fujiwara A et al (2011) Long-term results of surgical resection for pulmonary metastasis from renal cell carcinoma: a 25-year single-institution experience. Eur J Cardiothorac Surg 39:167–172

    Article  Google Scholar 

  14. Guinan P, Sobin LH, Algaba F et al (1997) TNM staging of renal cell carcinoma: Workgroup No. 3. Cancer 80:992–993

    Article  PubMed  CAS  Google Scholar 

  15. Staehler MD, Kruse J, Haseke N et al (2010) Liver resection for metastatic disease prolongs survival in renal cell carcinoma: 12-year results from a retrospective comparative analysis. World J Urol 28:543–547

    Google Scholar 

  16. Reddy S, Wolfgang CL (2009) The role of surgery in the management of isolated metastases to the pancreas. Lancet Oncol 10:287–293

    Article  PubMed  Google Scholar 

  17. Fujioka T, Obara W, Miki T et al (2009) Evidence-based clinical practice guidelines for renal cell carcinoma (Summary—JUA 2007). Int J Urol 16:339–353

    PubMed  Google Scholar 

  18. Assouad J, Banu E, Brian E et al (2008) Strategies and outcomes in pulmonary and extrapulmonary metastases from renal cell cancer. Eur J Cardiothorac Surg 33:794–798

    Article  PubMed  Google Scholar 

  19. Loehe F, Kobinger S, Hatz RA et al (2001) Value of systematic mediastinal lymph node dissection during pulmonary metastasectomy. Ann Thorac Surg 72:225

    Article  PubMed  CAS  Google Scholar 

  20. Cerfolio RJ, Allen MS, Deschamps C et al (1994) Pulmonary resection of metastatic renal cell carcinoma. Ann Thorac Surg 57:339–344

    Article  PubMed  CAS  Google Scholar 

  21. Friedel G, Hurtgen M, Penzenstadler M et al (1999) Resection of pulmonary metastases from renal cell carcinoma. Anticancer Res 19:1593–1596

    PubMed  CAS  Google Scholar 

  22. Plitz S, Meimarakis G, Wichmann MW et al (2002) Long-term results after pulmonary resection of renal cell carcinoma metastases. Ann Thorac Surg 73:1082–1087

    Article  Google Scholar 

  23. Pfannschmidt J, Hoffmann H, Muley T et al (2002) Prognostic factors for survival after pulmonary resection of metastatic renal cell carcinoma. Ann Thorac Surg 74:1653–1657

    Article  PubMed  Google Scholar 

  24. Sherry RM, Pass HI, Rosenberg SA et al (1992) Surgical resection of metastatic renal cell carcinoma and melanoma after response to interlerukin-2-based immunotherapy. Cancer 69:1850–1855

    Article  PubMed  CAS  Google Scholar 

  25. Kim B, Louie AC (1992) Surgical resection following interleukin 2 therapy for metastatic renal cell carcinoma prolongs remission. Arch Surg 127:1343–1349

    Article  PubMed  CAS  Google Scholar 

  26. Naito S, Yamamoto N, Takayama T et al (2010) Prognosis of Japanese metastatic renal cell carcinoma patients in the cytokine era: a cooperative group report of 1463 patients. Eur Urol 57:317–326

    Article  PubMed  CAS  Google Scholar 

  27. Motzer RJ, Basch E (2007) Targeted drugs of metastatic renal cell carcinoma. Lancet 370:2071–2073

    Article  PubMed  CAS  Google Scholar 

Download references

Conflict of interest

No author has any conflict of interest.

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Authors and Affiliations

  1. Department of Urology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Atsunari Kawashima, Daizo Oka, Mototaka Sato, Koji Hatano, Masatoshi Mukai, Akira Nagahara, Yasutomo Nakai, Hitoshi Takayama & Norio Nonomura

  2. Department of Urology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan

    Masashi Nakayama & Kazuo Nishimura

  3. Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

    Masayoshi Inoue & Meinoshin Okumura

  4. Department of General Thoracic Surgery, Nara Hospital of Kinki University School of Medicine, Ikoma, Nara, Japan

    Hiroyuki Shiono

Authors
  1. Atsunari Kawashima
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  2. Masashi Nakayama
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  3. Daizo Oka
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  4. Mototaka Sato
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  5. Koji Hatano
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  6. Masatoshi Mukai
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  7. Akira Nagahara
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  8. Yasutomo Nakai
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  9. Hitoshi Takayama
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  10. Masayoshi Inoue
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  11. Hiroyuki Shiono
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  12. Kazuo Nishimura
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  13. Meinoshin Okumura
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  14. Norio Nonomura
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Corresponding author

Correspondence to Norio Nonomura.

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Kawashima, A., Nakayama, M., Oka, D. et al. Pulmonary metastasectomy in patients with renal cell carcinoma: a single-institution experience. Int J Clin Oncol 16, 660–665 (2011). https://doi.org/10.1007/s10147-011-0244-0

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  • DOI: https://doi.org/10.1007/s10147-011-0244-0

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