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A case of acute aortic thrombosis after cisplatin-based chemotherapy

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Abstract

Cisplatin-based therapy is associated with various toxicities, including renal failure and neuropathy. However, acute arterial thrombosis is also a possible toxic effect of cisplatin, one that has been documented in a few cases worldwide. Here we present a rare case of ascending aortic thrombosis occurring 9 days after cisplatin-based chemotherapy in a 74-year-old male who was diagnosed with malignant pleural effusion suggestive of non-small cell lung cancer. The patient did not have any predisposing factor for the occurrence of an aortic thrombus before cisplatin-based chemotherapy. Thus, we suggest that the hypercoagulable state occurred secondary to cisplatin-based chemotherapy and was additive to the malignancy itself, causing aortic thrombosis. The patient was treated successfully with low-molecular-weight heparin and warfarin.

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Authors and Affiliations

  1. Department of Internal Medicine, Dongguk University Ilsan Hospital, 814 Sicksadong Ilsandong-gu, Goyang, 410-773, South Korea

    Suk Jae Hahn, Jin Young Oh & Do Yeun Kim

  2. Department of Radiology, Dongguk University Ilsan Hospital, Goyang, South Korea

    Jeung Sook Kim

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  1. Suk Jae Hahn
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  2. Jin Young Oh
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  3. Jeung Sook Kim
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  4. Do Yeun Kim
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Correspondence to Do Yeun Kim.

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Hahn, S.J., Oh, J.Y., Kim, J.S. et al. A case of acute aortic thrombosis after cisplatin-based chemotherapy. Int J Clin Oncol 16, 732–736 (2011). https://doi.org/10.1007/s10147-011-0205-7

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  • DOI: https://doi.org/10.1007/s10147-011-0205-7

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