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Survival and prognosticators of node-positive cervical cancer patients treated with radical hysterectomy and systematic lymphadenectomy

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Abstract

Objective

Lymph node metastasis (LNM) is known to be the most important prognostic factor in cervical cancer. We analyzed the number of positive lymph nodes and other clinicopathological factors as prognostic factors for survival in node-positive patients with cervical cancer.

Methods

Node-positive cervical cancer patients (n = 108) who underwent radical hysterectomy and systematic lymphadenectomy in Hokkaido University Hospital from 1982 to 2002 were enrolled. Clinicopathological data including age, stage, histologic subtype, and the number of LNM sites were collected. The main outcome was the overall survival (OS) rate for Stage Ib–IIb patients treated with surgery and postoperative radiotherapy.

Results

The 5-year OS rate of patients with 1 positive node was 93.3%, that for 2 nodes was 77.3%, for 3 nodes it was 33.3%, and for 4 or more it was 13.8%. The OS rate of patients with 1 or 2 LNM sites was significantly better than that for patients with more than 2 LNM sites. The OS rate of patients with adenocarcinoma (Ad) (28.6%) was significantly lower than that for patients with other histologic subtypes (squamous cell carcinoma; 66.7%, adenosquamous carcinoma; 75.0%, p = 0.0003). Multivariate analysis revealed that >2 LNM sites and Ad were independent prognostic factors for survival. The 5-year OS rate of patients with 1 or 2 LNM sites was 86.8%, a more favorable prognosis than the OS rates in other reports.

Conclusion

More than two LNM sites and adenocarcinoma were independent prognostic factors for node-positive patients with cervical cancer.

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Acknowledgments

We thank our colleagues (Department of Gynecology, Hokkaido University Graduate School of Medicine) for their assistance with the collection and analysis data.

Conflict of interest

No author has any conflict of interest.

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Authors and Affiliations

  1. Department of Gynecology, Hokkaido University Graduate School of Medicine, Kita-15, Nishi-7, Kita-ku, Sapporo, 060-8638, Japan

    Masayoshi Hosaka, Hidemichi Watari, Takashi Mitamura, Yousuke Konno, Tetsuji Odagiri, Tatsuya Kato, Mahito Takeda & Noriaki Sakuragi

Authors
  1. Masayoshi Hosaka
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  2. Hidemichi Watari
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  3. Takashi Mitamura
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  4. Yousuke Konno
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  5. Tetsuji Odagiri
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  6. Tatsuya Kato
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  7. Mahito Takeda
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  8. Noriaki Sakuragi
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Correspondence to Masayoshi Hosaka.

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Hosaka, M., Watari, H., Mitamura, T. et al. Survival and prognosticators of node-positive cervical cancer patients treated with radical hysterectomy and systematic lymphadenectomy. Int J Clin Oncol 16, 33–38 (2011). https://doi.org/10.1007/s10147-010-0123-0

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  • DOI: https://doi.org/10.1007/s10147-010-0123-0

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