Skip to main content

Advertisement

SpringerLink
Log in

Graft-versus-tumor effect after reduced-intensity allogeneic hematopoietic stem cell transplantation in a patient with advanced colon cancer

  • Case Report
  • Published:
International Journal of Clinical Oncology Aims and scope Submit manuscript

Abstract

A 27-year-old man with advanced colon cancer that was resistant to conventional chemoradiotherapies was treated with reduced-intensity allogeneic peripheral blood stem cell transplantation (PBSCT). After obtaining complete donor-type chimerism, there was an apparent graft-versus-tumor effect accompanied by severe hepatic graft-versus-host disease (GVHD) showing hyperbilirubinemia, resulting in a stable disease condition that lasted for 18 months, which had not been seen previously in his previous disease history. The antitumor effect observed in this patient was insufficient for the patient to achieve complete remission, because the disease was at an already widespread and treatment-resistant stage. He finally died of hepatic failure due to extensive liver GVHD 65 months after the diagnosis of the advanced colon cancer and 29 months after the allogeneic PBSCT. Prospective studies are necessary to achieve better clinical results in patients with advanced colon cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Saltz LB, Cox JV, Blanke C, et al. (2000) Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group. N Engl J Med 343:905–914

    Article  PubMed  CAS  Google Scholar 

  2. Holen KD, Saltz LB (2001) New therapies, new directions: advances in the systemic treatment of metastatic colorectal cancer. Lancet Oncol 2:290–297

    Article  PubMed  CAS  Google Scholar 

  3. Horowitz NM, Gale RP, Sondel PM, et al. (1990) Graft-versus-leukemia reactions after bone marrow transplantation. Blood 75:555–562

    PubMed  CAS  Google Scholar 

  4. Kolb HJ, Schattenberg A, Goldman JM, et al. (1995) Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients: European Group for Blood and Marrow Transplantation Working Party Chronic Leukemia. Blood 86:2041–2050

    PubMed  CAS  Google Scholar 

  5. Childs R, Chernoff A, Contentin N, et al. (2000) Regression of metastatic renal-cell carcinoma after nonmyeloablative allogeneic peripheral-blood stem-cell transplantation. N Engl J Med 343:750–758

    Article  PubMed  CAS  Google Scholar 

  6. Bregni M, Dodero A, Peccatori J, et al. (2002) Nonmyeloablative conditioning followed by hematopoietic cell allografting and donor lymphocyte infusions for patients with metastatic renal and breast cancer. Blood 99:4234–4236

    Article  PubMed  CAS  Google Scholar 

  7. Therasse P, Arbuck SG, Eisenhauser EA, et al. (2000) New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 92:205–216

    Article  PubMed  CAS  Google Scholar 

  8. Hurwitz H, Fehrenbacher L, Novotny W, et al. (2004) Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350:2335–2342

    Article  PubMed  CAS  Google Scholar 

  9. Cunningham D, Humblet Y, Siena S, et al. (2004) Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 351:337–345

    Article  PubMed  CAS  Google Scholar 

  10. Saltz LB, Meropol NJ, Loehrer PJ Sr, et al. (2004) Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol 22:1201–1208

    Article  PubMed  CAS  Google Scholar 

  11. Zetterquist H, Hentschke P, Thörne A, et al. (2001) A graft-versus-colonic cancer effect of allogeneic stem cell transplantation. Bone Marrow Transplant 28:1161–1166

    Article  PubMed  CAS  Google Scholar 

  12. Hentschke P, Barkholt L, Uzunel M, et al. (2003) Low-intensity conditioning and hematopoietic stem cell transplantation in patients with renal and colon carcinoma. Bone Marrow Transplant 31:253–261

    Article  PubMed  CAS  Google Scholar 

  13. Kojima R, Kami M, Hori A, et al. (2004) Reduced-intensity allogeneic hematopoietic stem-cell transplantation as an immunotherapy for metastatic colorectal cancer. Transplantation 78:1740–1746

    Article  PubMed  Google Scholar 

  14. Carnevale-Schianca F, Cignetti A, Capaldi A, et al. (2006) Allogeneic nonmyeloablative hematopoietic cell transplantation in metastatic colon cancer: tumor-specific T cells directed to a tumor-associated antigen are generated in vivo during GVHD. Blood 107:3795–3803

    Article  PubMed  CAS  Google Scholar 

  15. Falkenburg JHF, Wafelman AR, Joosten P, et al. (1999) Complete remission of accelerated phase chronic myeloid leukemia by treatment with leukemia-reactive cytotoxic T lymphocytes. Blood 94:1201–1208

    PubMed  CAS  Google Scholar 

  16. Atkins CD (1997) Guidelines for the use of carcinoembryonic antigen in colorectal cancer. J Clin Oncol 15:863–864

    PubMed  CAS  Google Scholar 

  17. Hori A, Kami M, Kim S-W, et al. (2004) Urgent need for a validated tumor response evaluation system for use in immunotherapy. Bone Marrow Transplant 33:255–256

    Article  PubMed  CAS  Google Scholar 

  18. Knechtli CJ, Goulden NJ, Hancock JP, et al. (1998) Minimal residual disease status before allogeneic bone marrow transplantation is an important determinant of successful outcome for children and adolescents with acute lymphoblastic leukemia. Blood 92:4072–4079

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Kita-15, Nishi-7, Kita-ku, Sapporo, 060-8648, Japan

    Satoshi Hashino, Sumiko Kobayashi, Mutsumi Takahata, Masahiro Onozawa, Masao Nakagawa, Takahito Kawamura, Fumie Fujisawa, Koh Izumiyama, Kaoru Kahata, Takeshi Kondo & Masahiro Asaka

Authors
  1. Satoshi Hashino
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sumiko Kobayashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mutsumi Takahata
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Masahiro Onozawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Masao Nakagawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Takahito Kawamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Fumie Fujisawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Koh Izumiyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Kaoru Kahata
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Takeshi Kondo
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Masahiro Asaka
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Satoshi Hashino.

About this article

Cite this article

Hashino, S., Kobayashi, S., Takahata, M. et al. Graft-versus-tumor effect after reduced-intensity allogeneic hematopoietic stem cell transplantation in a patient with advanced colon cancer. Int J Clin Oncol 13, 176–180 (2008). https://doi.org/10.1007/s10147-007-0716-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10147-007-0716-4

Key words

Search

Navigation