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Retrospective analysis of prognosis for scirrhous-type gastric cancer: one institution's experience

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Abstract

Background

Scirrhous gastric cancer is biologically aggressive, and the prognosis is poor even with curative surgery. We compared outcomes with different therapies in order to identify prognostic factors.

Methods

Records for 83 patients, who were treated between 1991 and 2004, were evaluated for survival and stage, treatment, and clinicopathological factors.

Results

Cumulative 5-year overall survival was 10.2% for all 83 patients, including 27 (32.5%) patients with stage II/III disease and 56 (67.4%) with stage IV disease. The 5-year overall survival rate and median survival time for patients with stage II/III disease after curative surgery were 24.3% and 1150 days. For patients with stage IV disease, 2-year and 5-year survival rates after initial surgery were 13.7% and 0% and median survival was 250 days. In contrast, preoperative chemotherapy for advanced, unresectable disease produced 2-year and 3-year overall survival rates of 53.6% and 26.8% and medican survival was 910 days.

Conclusion

Aggressive surgery alone does not seem to improve outcome, but preoperative chemotherapy might be beneficial and should be investigated further.

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References

  1. K Kitamura R Beppu H Anai et al. (1995) ArticleTitleClinicopathologic study of patients with Borrmann type IV gastric carcinoma J Surg Oncol 58 112–117 Occurrence Handle7844980 Occurrence Handle10.1002/jso.2930580208 Occurrence Handle1:STN:280:ByqC2cjksVc%3D

    Article  PubMed  CAS  Google Scholar 

  2. Y Maehara S Moriguchi H Orita et al. (1992) ArticleTitleLower survival rate for patients with carcinoma of the stomach of Borrmann type IV after gastric resection Surg Gynecol Obstet 175 13–16 Occurrence Handle1621194 Occurrence Handle1:STN:280:By2A38%2FksVE%3D

    PubMed  CAS  Google Scholar 

  3. P Arveneux J Faivre M-C Boutron et al. (1992) ArticleTitlePrognosis of gastric carcinoma after curative surgery: a population-based study using multivariate crude and relative survival analysis Dig Dis Sci 37 757–763 Occurrence Handle10.1007/BF01296435

    Article  Google Scholar 

  4. S Kinugasa S Abe M Tachibana et al. (1997) ArticleTitleSurgically curable and incurable scirrhous carcinomas of the stomach J Surg Oncol 65 194–200 Occurrence Handle9236929 Occurrence Handle10.1002/(SICI)1096-9098(199707)65:3<194::AID-JSO9>3.0.CO;2-1 Occurrence Handle1:STN:280:ByiA1c%2FhtlQ%3D

    Article  PubMed  CAS  Google Scholar 

  5. E Otsuji Y Kuriu K Okamoto et al. (2004) ArticleTitleOutcome of surgical treatment for patients with scirrhous carcinoma of the stomach Am J Surg 188 327–332 Occurrence Handle15450843 Occurrence Handle10.1016/j.amjsurg.2004.06.010

    Article  PubMed  Google Scholar 

  6. W Koizumi S Tanabe K Saigenji et al. (2003) ArticleTitlePhase I/II study of S-1 with cisplatin in patients with advanced gastric cancer Br J Cancer 89 2207–2212 Occurrence Handle14676796 Occurrence Handle10.1038/sj.bjc.6601413 Occurrence Handle1:CAS:528:DC%2BD3sXpvVShtbc%3D

    Article  PubMed  CAS  Google Scholar 

  7. Y Saikawa Y Akasaka T Kanai et al. (2003) ArticleTitlePreoperative combination chemotherapy with S-1 and low-dose cisplatin against highly advanced gastric carcinoma Oncol Rep 10 381–386 Occurrence Handle12579276 Occurrence Handle1:CAS:528:DC%2BD3sXhvFGksLw%3D

    PubMed  CAS  Google Scholar 

  8. InstitutionalAuthorNameJapanese Gastric Cancer Association (1998) ArticleTitleJapanese classification of gastric carcinoma – 2nd English edition Gastric Cancer 1 10–24 Occurrence Handle11957040 Occurrence Handle10.1007/PL00011681

    Article  PubMed  Google Scholar 

  9. S Kinugasa S Abe M Tachibana et al. (1997) ArticleTitleSurgically curable and incurable scirrhous carcinomas of the stomach J Surg Oncol 65 194–200 Occurrence Handle9236929 Occurrence Handle10.1002/(SICI)1096-9098(199707)65:3<194::AID-JSO9>3.0.CO;2-1 Occurrence Handle1:STN:280:ByiA1c%2FhtlQ%3D

    Article  PubMed  CAS  Google Scholar 

  10. H Furukawa M Hiratsuka T Iwanaga et al. (1997) ArticleTitleExtended surgery – left upper abdominal exenteration plus Appleby's method – for type 4 gastric carcinoma Ann Surg Oncol 4 209–214 Occurrence Handle9142381 Occurrence Handle10.1007/BF02306612 Occurrence Handle1:STN:280:ByiB1cjivV0%3D

    Article  PubMed  CAS  Google Scholar 

  11. GV Aranha R Georgen (1989) ArticleTitleGastric linitis plastica is not a surgical disease Surgery 106 758–762 Occurrence Handle2552599 Occurrence Handle1:STN:280:By%2BD3MbpslE%3D

    PubMed  CAS  Google Scholar 

  12. C Kunisaki H Shimada M Nomura et al. (2005) ArticleTitleTherapeutic strategy for scirrhous type gastric cancer Hepatogastroenterology 52 314–318 Occurrence Handle15783058

    PubMed  Google Scholar 

  13. S Suga H Iwase M Shimada et al. (1996) ArticleTitleNeoadjuvant chemotherapy in scirrhous gastric cancer of the stomach using uracil and tegafur and cisplatin Intern Med 35 930–936 Occurrence Handle9030989 Occurrence Handle1:CAS:528:DyaK2sXit1aqtbY%3D

    PubMed  CAS  Google Scholar 

  14. T Kinoshita M Konishi T Nakagohri et al. (2003) ArticleTitleNeoadjuvant chemotherapy with S-1 for scirrhous gastric cancer: a pilot study Gastric Cancer 6 40–44 Occurrence Handle12775019 Occurrence Handle10.1007/s10120-003-0220-0

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Surgery, School of Medicine, Keio University, Shinanomachi 35, Shinjuku-ku, Tokyo, 160-8582, Japan

    Rieko Nakamura, Yoshiro Saikawa, Norihito Wada, Masashi Yoshida & Masaki Kitajima

  2. Center for Comprehensive and Advanced Medicine, Keio University, Tokyo, Japan

    Tetsuro Kubota

  3. Center for Diagnostic and Therapeutic Endoscopy, Keio University, Tokyo, Japan

    Koichiro Kumai

Authors
  1. Rieko Nakamura
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  2. Yoshiro Saikawa
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  3. Norihito Wada
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  4. Masashi Yoshida
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  5. Tetsuro Kubota
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  6. Koichiro Kumai
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  7. Masaki Kitajima
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Corresponding author

Correspondence to Yoshiro Saikawa.

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Nakamura, R., Saikawa, Y., Wada, N. et al. Retrospective analysis of prognosis for scirrhous-type gastric cancer: one institution's experience. Int J Clin Oncol 12, 291–294 (2007). https://doi.org/10.1007/s10147-007-0683-9

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  • DOI: https://doi.org/10.1007/s10147-007-0683-9

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