Abstract
A 70-year-old Japanese man presented to our hospital with a 1-month history of progressive general fatigue and anorexia. A physical examination revealed severe anemic condition, mild persistent splenomegaly, and no palpable surface lymph nodes. He had pleural effusion and ascites, though no malignant cells were detected in the effusion. He eventually died without any diagnosis of his disease. Immunohistochemical staining of his tumor after autopsy showed atypical cells that were negative for epithelial membrane antigen (EMA), keratin (AE1/3), keratin-20, vimentin, factor VIII, leukocyte common antigen (LCA/T200; CD45), myeloperoxidase (MPO), terminal deoxynucleotidyl tranferase (TdT), lysozyme, CD1a, CD3, CD4, CD10, CD15, CD20 (L26), CD21, CD23, CD34, CD43, CD56, CD68, CD79a, CD138, and EBER-1 in situ. Only a few scattered cells expressed CD30, but they showed no staining for anaplastic large-cell lymphoma kinase (ALK). A few scattered cells expressed S-100 antigen and the majority of cells dominantly expressed dendritic cell-associated antigens (CD35, FDC, Ki-M1p). In conclusion, we found this unknown primary tumor to be consistent with a follicular dendritic cell tumor with anaplastic features.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
BC Lembersky LC Thomas (1996) ArticleTitleMetastases of unknown primary site Med Clin North Am 80 153–171 Occurrence Handle8569295 Occurrence Handle10.1016/S0025-7125(05)70433-8 Occurrence Handle1:STN:280:BymC3M%2FosFE%3D
JL Abbruzzese MC Abbruzzese KR Hess et al. (1994) ArticleTitleUnknown primary carcinoma: natural history and prognostic factors in 657 consecutive patients J Clin Oncol 12 1272–1280 Occurrence Handle8201389 Occurrence Handle1:STN:280:ByuB28%2FislM%3D
L Monda R Warnke J Rosai (1986) ArticleTitleA primary lymph node malignancy with features suggestive of dendritic reticulum cell differentiation, a report of four cases Am J Pathol 122 562–572 Occurrence Handle2420185 Occurrence Handle1:STN:280:BimC2MnhtF0%3D
LM Weiss (1992) Histiocytic and dendritic proliferations DM Knowles (Eds) Neoplastic hematopathology Williams & Wilkins Baltimore 1459–1484
ES Jaff LM Weiss TM Grogan et al. (2001) WHO histological classification of histiocytic and dendritic cell neoplasms ES Jaff (Eds) Tumors of haematopoietic and lymphoid tissues IARC Lyon 273–289
JK Chan CD Fletcher SJ Nayler et al. (1997) ArticleTitleFollicular dendritic cell sarcoma. Clinicopathologic analysis of 17 cases suggesting a malignant potential higher than currently recognized Cancer 79 294–313 Occurrence Handle9010103 Occurrence Handle10.1002/(SICI)1097-0142(19970115)79:2<294::AID-CNCR13>3.0.CO;2-W Occurrence Handle1:STN:280:ByiC28zis1w%3D
B Perez-Ordonez J Rosai (1998) ArticleTitleFollicular dendritic cell tumor: review of the entity Semin Diagn Pathol 15 144–154 Occurrence Handle9606805 Occurrence Handle1:STN:280:DyaK1c3mvFKmsg%3D%3D
R Fonseca M Yamakawa S Nakamura et al. (1998) ArticleTitleFollicular dendritic cell sarcoma and interdigitating reticulum cell sarcoma: a review Am J Hematol 59 161–167 Occurrence Handle9766802 Occurrence Handle10.1002/(SICI)1096-8652(199810)59:2<161::AID-AJH10>3.0.CO;2-C Occurrence Handle1:CAS:528:DyaK1cXmsF2lsb0%3D
SA Pileri TM Grogan NL Harris et al. (2002) ArticleTitleTumors or histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases Histopathology 41 1–29 Occurrence Handle12121233 Occurrence Handle10.1046/j.1365-2559.2002.01418.x Occurrence Handle1:STN:280:DC%2BD38vhs1Wmsw%3D%3D
ES Jaffe (1995) Malignant histiocytosis and true histiocytic lymphomas ES Jaffe (Eds) Surgical pathology of lymph nodes and related organs WB Saunders Philadelphia 560–593
DT Nguyen LW Diamond ML Hansmann et al. (1994) ArticleTitleFollicular dendritic cell sarcoma. Identification by monoclonal antibodies in paraffin sections Appl Immunohistochem 2 60–64
K Maeda M Matsuda H Suzuki et al. (2002) ArticleTitleImmunohistochemical recognition of human follicular dendritic cells (FDCs) in routinely processed paraffin sections J Histochem Cytochem 50 1475–1485 Occurrence Handle12417613 Occurrence Handle1:CAS:528:DC%2BD38XpslGitrg%3D
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Yakushijin, Y., Shikata, H., Kito, K. et al. Follicular dendritic cell tumor as an unknown primary tumor. Int J Clin Oncol 12, 56–58 (2007). https://doi.org/10.1007/s10147-006-0626-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10147-006-0626-x