Abstract
Background
As the origin and pathology of inflammatory pseudotumor is not clearly understood, there has recently been some confusion regarding the diagnosis of inflammatory pseudotumor.
Methods
We performed clinicopathological analyses in seven patients with inflammatory pseudotumors of the lung histologically diagnosed after surgical resection. The seven patients, selected from patients admitted to Kawasaki Medical School Hospital between April 1989 and December 2005, consisted of four men and three women (average age, 60.4 years). The detection method was from clinical symptoms in two patients and from health examinations in five patients.
Results
Five patients had a solitary nodular shadow on chest radiographs and the other two patients had multiple shadows. Because it was difficult to distinguish pseudotumor from lung cancer by chest computed tomography in the five patients showing a solitary nodular shadow, the final diagnosis was obtained by surgical resection. In the other two patients, with multiple shadows, one of whom had nodular shadows with cavitary lesions, surgical resection was performed to distinguish the pseudotumor from metastatic lung cancer. The histological types according to the criteria of Matsubara were fibrous histiocytic in five patients, organizing pneumonia in one, and lymphoplasmocytic in one. The histological types according to the World Health Organization criteria were compact spindle-cell pattern in six patients and hypocellular fibrous pattern in one.
Conclusion
Because it is difficult to make a preoperative diagnosis of inflammatory pseudotumor by radiological findings or histological findings using specimens obtained by transbronchial lung biopsy, surgical resection, such as video-assisted thoracic surgery or open lung biopsy, is required to differentiate inflammatory pseudotumors from primary or metastatic lung cancers.
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References
O Matsubara NS Tan-Liu RM Kenney et al. (1988) ArticleTitleInflammatory pseudotumor of the lung: progression from organizing pneumonia to fibrous histiocytoma or to plasma cell granuloma in 32 cases Hum Pathol 19 807–814 Occurrence Handle2841219 Occurrence Handle10.1016/S0046-8177(88)80264-8 Occurrence Handle1:STN:280:BieB1Mjms1A%3D
D Carter AS Patchefsky (1998) Tumors and tumor-like lesions of the lung WB Saunders Philadelphia 312–322
RJ Cerfolio MS Allen AG Nascimento et al. (1999) ArticleTitleInflammatory pseudotumors of the lung Ann Thorac Surg 67 933–936 Occurrence Handle10320231 Occurrence Handle10.1016/S0003-4975(99)00155-1 Occurrence Handle1:STN:280:DyaK1M3ltF2kuw%3D%3D
A Water D Satge N Roeslin (1987) ArticleTitleAngioinvasive plasma cell granuloma of the lung Cancer 59 435–443 Occurrence Handle10.1002/1097-0142(19870201)59:3<435::AID-CNCR2820590315>3.0.CO;2-6
G Pettiano JC Manviel ND Rosa (1990) ArticleTitleInflammatory myofibroblastic tumor (plasma cell granuloma). Clinicopathological study of 20 cases with immunohistochemical and ultrastructual observations Am J Clin Pathol 94 538–546
TV Colby MN Koss WD Travis (1995) Tumors of the lower respiratory tract Armed Forces Institute of Pathology Washington DC 327–352
O Matsubara EJ Mark (1994) Tumor-like lesion of the lung and pleura Pathology of pulmonary disease JB Lippincott Philadelphia 711–720
T Harada K Watanabe A Iwasaki et al. (2003) ArticleTitleFour cases of inflammatory pseudotumor (in Japanese, Abstract in English) Jpn J Thorac Dis 41 402–406
T Yokoi (1998) ArticleTitleInflammatory pseudotumor (in Japanese, Abstract in English) Jpn J Chest Dis 57 S81–S85
MC Copin BH Gosselin ME Ribet (2002) Inflammatory myofibroblastic tumor Fletcher KK Unni F Mertens (Eds) World Health Organization classification of tumor: pathology and genetics, tumor of soft tissue and bone IARC Lyon 91–93
D Carter JC Eggleston (1998) Tumors of the lower respiratory tract Armed Forces Institute of Pathology Washington DC 300–307
RG Fisher PF Wright JE Johnson (1995) ArticleTitleInflammatory pseudotumor presenting as fever of unknown origin Clin Infect Dis 21 1492–1494 Occurrence Handle8749642 Occurrence Handle1:STN:280:BymA2M7ltVA%3D
P Rohrlich M Puechmaur SN Cocci et al. (2001) ArticleTitleInterleukin-6 and interleukin-1 beta production in a pediatric plasma cell granuloma of the lung Am J Surg Pathol 25 761–768 Occurrence Handle10.1097/00000478-200106000-00007
JKC Chan W Cheuk M Shimizu (2001) ArticleTitleAnaplastic lymphoma kinase expression in inflammatory pseudotumors Am J Surg Pathol 25 761–768 Occurrence Handle11395553 Occurrence Handle10.1097/00000478-200106000-00007 Occurrence Handle1:STN:280:DC%2BD3Mzislekuw%3D%3D
JR Cook LP Dehner MH Collins et al. (2001) ArticleTitleAnaplastic lymphoma kinase (ALK) expression in the inflammatory myofibroblastic tumor. A comparative immunohistochemical study Am J Surg Pathol 25 1364–1371 Occurrence Handle11684952 Occurrence Handle10.1097/00000478-200111000-00003 Occurrence Handle1:STN:280:DC%2BD3MnkvVehtw%3D%3D
CM Ciffin A Patel S Perkin et al. (2001) ArticleTitleALK1 and p80 expression and chromosomal rearrangements involving 2 p23 in inflammatory myofibroblastic tumor Mod Pathol 14 569–576 Occurrence Handle10.1038/modpathol.3880352
S Umeki (1993) ArticleTitleA case of plasma cell granuloma which resolved after steroid treatment (in Japanese, Abstract in English) Jpn J Thorac Dis 31 123–126 Occurrence Handle1:STN:280:ByyB38risFY%3D
T Bando M Fujimura Y Noda et al. (1994) ArticleTitlePulmonary plasma cell granuloma improves with corticosteroid therapy Chest 105 1574–1575 Occurrence Handle8181356 Occurrence Handle1:STN:280:ByuB3sjgt1w%3D
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Kobashi, Y., Fukuda, M., Nakata, M. et al. Inflammatory pseudotumor of the lung: clinicopathological analysis in seven adult patients. Int J Clin Oncol 11, 461–466 (2006). https://doi.org/10.1007/s10147-006-0611-4
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DOI: https://doi.org/10.1007/s10147-006-0611-4