Skip to main content

Advertisement

SpringerLink
Log in

Acute urinary morbidity following I-125 prostate brachytherapy

  • ORIGINAL ARTICLE
  • Published:
International Journal of Clinical Oncology Aims and scope Submit manuscript

Abstract

Background

In Japan, iodine-125 (I-125) prostate brachytherapy has been legally approved since July 2003, and this method is becoming more popular. The purpose of the present study was to assess acute urinary morbidity within the first 6 months after I-125 prostate brachytherapy.

Methods

A group of 130 consecutive patients with loca-lized prostate cancer was treated with I-125 prostate brachytherapy between September 2003 and June 2004,either alone (monotherapy; 66 patients) or in combination with external-beam radiotherapy (combined therapy; 64 patients). Urinary morbidity was evaluated using the National Cancer Institute – Common Terminology Criteria for Adverse Events, version 3.0.

Results

During the follow-up, 111 patients (85.4%) developed some degree of urinary symptoms such as frequency, retention, dysuria, incontinence, or hematuria. Urinaryfrequency (73.1%) and retention (66.9%) were the most common, and showed no significant differences between the monotherapy group and combined therapy group (P = 0.352 and P = 0.630, respectively). Six patients (4.6%) required catheterization for urinary obstruction; the median timeto onset was 1.5 days (range, 1–192 days). Five of these6 patients received monotherapy and the other received combined therapy.

Conclusion

Manifestations of acute urinary morbidity, especially frequency and retention, are relatively common but acceptable events after I-125 prostate brachytherapy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. O Pasteau P Degrais (1914) ArticleTitleThe radium treatment of cancer of the prostate Arch Roentgenol Ray 18 396–410

    Google Scholar 

  2. WF Whitmore B Hilaris H Grabstald (1972) ArticleTitleRetropubic implantation of iodine-125 in the treatment of prostate cancer J Urol 108 918–920 Occurrence Handle5082747

    PubMed  Google Scholar 

  3. HH Holm N Juul JF Pedersen et al. (1983) ArticleTitleTransperineal iodine-125 seed implantation in prostatic cancer guided transrectal ultrasonography J Urol 130 283–286 Occurrence Handle6876274

    PubMed  Google Scholar 

  4. S Nag W Bice K DeWyngaert et al. (2000) ArticleTitleThe American Brachytherapy Society recommendations for permanent prostate brachytherapy postimplant dosimetric analysis Int J Radiat Oncol Biol Phys 46 221–230 Occurrence Handle10.1016/S0360-3016(99)00351-X Occurrence Handle10656396

    Article  PubMed  Google Scholar 

  5. BH Han KC Demel K Wallner et al. (2001) ArticleTitlePatient reported complications after prostate brachytherapy J Urol 166 953–957 Occurrence Handle10.1097/00005392-200109000-00033 Occurrence Handle11490253

    Article  PubMed  Google Scholar 

  6. GS Merrick WM Butler JH Life et al. (2000) ArticleTitleTemporal resolution of urinary morbidity following prostate brachytherapy Int J Radiat Oncol Biol Phys 47 121–128 Occurrence Handle10.1016/S0360-3016(99)00525-8 Occurrence Handle10758313

    Article  PubMed  Google Scholar 

  7. P Wust DW Borczyskowski T Henkel et al. (2004) ArticleTitleClinicaland physical determinants for toxicity of 125-I seed prostate brachytherapy Radiother Oncol 73 39–48 Occurrence Handle10.1016/j.radonc.2004.08.003 Occurrence Handle15465144

    Article  PubMed  Google Scholar 

  8. JC Blasko H Ragde PD Grimm (1991) ArticleTitleTransperineal ultrasound-guided implantation of the prostate: morbidity and complications Scand J Urol Nephrol Suppl 137 113–118 Occurrence Handle1947828

    PubMed  Google Scholar 

  9. KW Kaye DJ Olson JT Payne et al. (1995) ArticleTitleDetailed preliminary analysis of 125-iodine implantation for localized prostate cancer using percutaneous approach J Urol 153 1020–1025 Occurrence Handle10.1097/00005392-199503001-00030 Occurrence Handle7531784

    Article  PubMed  Google Scholar 

  10. M Dattoli K Wallner R Sorace et al. (1996) ArticleTitle103Pd brachytherapy and external beam irradiation for clinically localized, high-risk prostatic carcinoma Int J Radiat Oncol Biol Phys 35 875–879 Occurrence Handle10.1016/0360-3016(96)00214-3 Occurrence Handle8751395

    Article  PubMed  Google Scholar 

  11. N Lee C Wuu R Brody et al. (2000) ArticleTitleFactors predicting for postimplantation urinary retention after permanent prostate brachytherapy Int J Radiat Oncol Biol Phys 48 1457–1460 Occurrence Handle10.1016/S0360-3016(00)00784-7 Occurrence Handle11121648

    Article  PubMed  Google Scholar 

  12. J Bucci WJ Morris M Keyes et al. (2002) ArticleTitlePredictive factors of urinary retention following prostate brachytherapy Int J Radiat Oncol Biol Phys 53 91–98 Occurrence Handle10.1016/S0360-3016(01)02812-7 Occurrence Handle12007946

    Article  PubMed  Google Scholar 

  13. DJ Schwartz SE Schild WW Wong et al. (2005) ArticleTitleFactorsassociated with the frequency of self-intermittent catheterization after prostate brachytherapy Int J Radiat Oncol Biol Phys 61 60–63 Occurrence Handle10.1016/j.ijrobp.2004.04.054 Occurrence Handle15629594

    Article  PubMed  Google Scholar 

  14. D Fleming InstitutionalAuthorNameAmerican Joint Committee on Cancer, NationalCancer Institute (US) et al. (1997) AJCC cancer staging manual Lippincott-Raven Philadelphia

    Google Scholar 

  15. A Trotti AD Colevas A Setser et al. (2003) ArticleTitleCTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatment Semin Radiat Oncol 13 176–181 Occurrence Handle10.1016/S1053-4296(03)00031-6 Occurrence Handle12903007

    Article  PubMed  Google Scholar 

  16. H Ragde AA Elgamal PB Snow et al. (1998) ArticleTitleTen-year disease-free survival after transperineal sonography-guided iodine-125 brachytherapy with or without 45-Gray external beam irradiation in the treatment of patients with clinically localized, low to high Gleason grade prostate carcinoma Cancer 83 989–1001 Occurrence Handle10.1002/(SICI)1097-0142(19980901)83:5<989::AID-CNCR26>3.0.CO;2-Q Occurrence Handle9731904

    Article  PubMed  Google Scholar 

  17. H Ragde JC Blasko PD Grimm et al. (1997) ArticleTitleInterstitial iodine-125 radiation without adjuvant therapy in the treatment of clinically localized prostate cancer Cancer 80 442–453 Occurrence Handle10.1002/(SICI)1097-0142(19970801)80:3<442::AID-CNCR12>3.0.CO;2-X Occurrence Handle9241078

    Article  PubMed  Google Scholar 

  18. H Ragde JC Blasko PD Grimm et al. (1997) ArticleTitleBrachytherapy for clinically localized prostate cancer: results at 7 and 8 year follow-up Semin Surg Oncol 13 438–443 Occurrence Handle10.1002/(SICI)1098-2388(199711/12)13:6<438::AID-SSU8>3.0.CO;2-B Occurrence Handle9358591

    Article  PubMed  Google Scholar 

  19. N Salem M Simonian-Sauve R Rosello et al. (2003) ArticleTitlePredictive factors of acute urinary morbidity after iodine-125 brachytherapy for localized prostate cancer: a phase 2 study Radiother Oncol 66 159–165 Occurrence Handle10.1016/S0167-8140(03)00004-5 Occurrence Handle12648787

    Article  PubMed  Google Scholar 

  20. S Mallick R Azzouzi L Cormier et al. (2003) ArticleTitleUrinary morbidity after 125I brachytherapy of the prostate Br J Urol 92 555–558

    Google Scholar 

  21. FJ Fowler SuffixJr MJ Barry G Lu-Yao et al. (1993) ArticleTitlePatient-reported complications and follow-up treatment after radical prostatectomy. The National Medicare Experience: 1988–1990 (updated June 1993) Urology 42 622–629 Occurrence Handle10.1016/0090-4295(93)90524-E Occurrence Handle8256394

    Article  PubMed  Google Scholar 

  22. DY Gelblum L Potters R Ashley et al. (1997) ArticleTitleUrinary morbidity following ultrasound-guided transperineal prostate seed implantation Int J Radiat Oncol Biol Phys 45 59–67 Occurrence Handle10.1016/S0360-3016(99)00176-5

    Article  Google Scholar 

  23. K Wallner H Lee S Wasserman M Dattoli (1997) ArticleTitleLow risk of urinary incontinence following prostate brachytherapy in patients with a prior transurethral prostate resection Int J Radiat Oncol Biol Phys 37 565–569 Occurrence Handle10.1016/S0360-3016(96)00570-6 Occurrence Handle9112454

    Article  PubMed  Google Scholar 

  24. MD Terk RG Stock NN Stone (1998) ArticleTitleIdentification of patientsat increased risk for prolonged urinary retention followingradioactive seed implantation of the prostate J Urol 160 1379–1382 Occurrence Handle10.1097/00005392-199810000-00044 Occurrence Handle9751358

    Article  PubMed  Google Scholar 

  25. J Crook M McLean C Catton et al. (2002) ArticleTitleFactors influencingrisk of acute urinary retention after TRUS-guided permanentprostate seed implantation Int J Radiat Oncol Biol Phys 52 453–460 Occurrence Handle10.1016/S0360-3016(01)02658-X Occurrence Handle11872292

    Article  PubMed  Google Scholar 

  26. GS Merrick WM Butler KE Wallner et al. (2004) ArticleTitleThe effect of hormonal manipulation on urinary function following permanent prostate brachytherapy Brachytherapy 3 22–29 Occurrence Handle10.1016/j.brachy.2003.12.001 Occurrence Handle15110310

    Article  PubMed  Google Scholar 

  27. BR Prestidge WS Bice EJ Kiefer et al. (1998) ArticleTitleTiming ofcomputed tomography-based postimplant assessment following permanent transperineal prostate brachytherapy Int J Radiat Oncol Biol Phys 40 1111–1115 Occurrence Handle10.1016/S0360-3016(97)00947-4 Occurrence Handle9539566

    Article  PubMed  Google Scholar 

  28. FM Waterman AP Dicker (2002) ArticleTitleImpact of postimplant edema on V100 and D90 in prostate brachytherapy: can implant quality be predicted on day 0? Int J Radiat Oncol Biol Phys 53 610–621 Occurrence Handle10.1016/S0360-3016(02)02751-7 Occurrence Handle12062604

    Article  PubMed  Google Scholar 

  29. TG Shanahan PW Mueller DA Roszhart et al. (2004) ArticleTitleImage guided I 125 prostate brachytherapy with hybrid interactive Mick technique in the community setting: how does it compare? Technol Cancer Res Treat 3 209–215 Occurrence Handle15059027

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiology, Tokyo Medical Center, National Hospital Organization, 2-5-1 Higashigaoka, Meguro-ku, Tokyo, 152-8902, Japan

    Toshio Ohashi, Atsunori Yorozu & Kazuhito Toya

  2. Department of Urology, Tokyo Medical Center, National Hospital Organization, Tokyo, Japan

    Shiro Saito & Tetsuo Momma

Authors
  1. Toshio Ohashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Atsunori Yorozu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kazuhito Toya
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Shiro Saito
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Tetsuo Momma
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Toshio Ohashi.

About this article

Cite this article

Ohashi, T., Yorozu, A., Toya, K. et al. Acute urinary morbidity following I-125 prostate brachytherapy. Int J Clin Oncol 10, 262–268 (2005). https://doi.org/10.1007/s10147-005-0507-8

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10147-005-0507-8

Key words

Search

Navigation