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Prognostic value of thymidine phosphorylase activity in liver tissue adjacent to hepatocellular carcinoma

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Abstract

Background

Measurement of thymidine phosphorylase (TP) activity in normal liver tissue adjacent to hepatocellular carcinoma (HCC) may predict multicentric recurrence a long time after an operation. The authors investigated this activity in 92 patients with HCC who had a single HCC equal to or less than 5 cm.

Methods

Fresh samples (tumors with adjacent normal tissues) were collected from 92 patients with HCC who underwent curative hepatic resection. The levels of TP activity in nonfixed, fresh, and frozen HCC specimens with adjacent noncancerous liver tissue were biochemically measured by using an enzyme-linked immunosorbent assay method.

Results

Patients who had a high TP level in normal liver tissue had significantly earlier recurrence (median disease-free survival, 819 days; 95% confidence interval [95% CI], 478–1044 days) compared with patients who had a low TP level (median disease-free survival, 1376 days; lower limit of 95% CI, 921 days; P = 0.0171). Multivariate analysis showed that patients who had a low TP level in adjacent liver tissue had a 0.387-fold higher risk of postoperative recurrence compared with patients who had a high TP level (P = 0.0067).

Conclusion

TP activity in normal liver tissue adjacent to HCC is related to tumor occurrence and may predict postoperative tumor recurrence.

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Authors and Affiliations

  1. Department of Disaster and Emergency Medicine, Graduate School of Medical Science, Kyushu University, Fukuoka, 812-8582, Japan

    Takahiro Ezaki & Makoto Hashizume

  2. Department of Surgery, Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital, Hiroshima, Japan

    Toru Ikegami, Takashi Maeda & Teruyoshi Ishida

  3. Department of Medical Information Science, Kyushu University Hospital, Fukuoka, Japan

    Tomomi Yamada

  4. Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Yoshihiko Maehara

Authors
  1. Takahiro Ezaki
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  2. Toru Ikegami
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  3. Takashi Maeda
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  4. Tomomi Yamada
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  5. Teruyoshi Ishida
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  6. Makoto Hashizume
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  7. Yoshihiko Maehara
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Correspondence to Takahiro Ezaki.

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Ezaki, T., Ikegami, T., Maeda, T. et al. Prognostic value of thymidine phosphorylase activity in liver tissue adjacent to hepatocellular carcinoma. Int J Clin Oncol 10, 171–176 (2005). https://doi.org/10.1007/s10147-005-0488-7

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  • DOI: https://doi.org/10.1007/s10147-005-0488-7

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